Tubal ektopik gebeliklerde metotreksat tedavi başarısını öngörmede nötrofil-lenfosit oranı ve platelet-lenfosit oranı

Yıl 2016, Cilt: 6 Sayı: 1, 25 - 29, 19.10.2016

Hatice Yılmaz Doğru , Çiğdem Kunt İşgüder Asker Zeki Özsoy İlhan Bahri Delibas Bülent Cakmak Akgul Arici

https://doi.org/10.16899/ctd.07462

Öz

Giriş

Ektopik gebelik tüm gebeliklerin %2'sini oluşturmakta, aynı zamanda vakaların %95'ten fazlası fallop tüplerinde lokalizedir. Bu çalışmada; tubal gebeliklerde metotreksat tedavi başarısını değerlendirmek, ve nötrofil-lenfosit oranı, trombosit-lenfosit oranı ve tubal ektopik gebelik rüptürü arasındaki ilişkiyi incelemek amaçlanmıştır.

Gereç ve Yöntem

Bu retrospektif çalışma, Gaziosmanpasa Üniversitesi, Kadın Hastalıkları ve Doğum Anabilim Dalı'nda 2012 ve 2014 yılları arasında yapılmıştır. Veriler Statistical Package for Social Sciences (SPSS) yazılım versiyonu 20.0 (SPSS Inc., Chicago, IL) ile analiz edildi. Tüm karşılaştırmalarda çift taraflı p değeri < 0.05 olarak kabul edildi.

Bulgular

Nötrofil-lenfosit oranı rüptüre olup cerrahi tedavi geçirmiş hastalarda rüptüre olmayıp metotreksat tedavisi alan hastalara göre yüksek saptandı (p = 0.009). Beraberinde, nötrofil-lenfosit oranı metotreksat tedavisine yanıt veren hastalarda yanıt vermeyenlere göre yüksek bulundu (p = 0.027). 

Sonuç

Ektopik gebelik kese çapı ve B-HCG değeri yanında, nötrofil-lenfosit oranı ve platelet-lenfosit oranı metotreksat tedavisinin başarısını öngörmede yararlı belirteçler olabilirler.

Anahtar Kelimeler

Gebelik, Ektopik, Metotreksat, Nötrofil, Lenfosit, Plateletler

Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio on the prediction of methotrexate treatment success in tubal ectopic pregnancy

Öz

Objective

A %2 of all pregnancies composed of ectopic pregnancy, further more than 95% of cases localized on the fallopian tubes. The aim of this study is to assess the success of metotrexate treatment on tubal pregnancy, and the relation between the neutrophil-lymphocyte ratio and thrombocyte-lymphocyte ratio, and tubal ectopic pregnancy rupture.

Materials and Methods

This retrospective study was conducted in Gaziosmanpasa University, Department of Obstetrics and Gynecology between 2012 and 2014. Patients with a diagnosis of tubal ectopic pregnancy whose admitted to the Department of Obstetrics and Gynecology were enrolled in the study. The data was analyzed using the Statistical Package for Social Sciences (SPSS) software version 20 (SPSS Inc., Chicago, IL). A two-tailed p value <0.05 was regarded as statistically significant for all comparisons.

Results

The neurophil-lymphocyte ratio was significantly higher in ruptured surgical treated patients compared to unruptured-methotrexate treated patients (p = 0.009). Additionally, the neurophil-lymphocyte ratio was significantly higher in methotrexate responsive patients than in non-responsive ones (p = 0.027). 

Conclusion

Beside B-HCG level and ectopic pregnancy sac diameter, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio may be useful tools to predict the success of the methotrexate therapy.

Anahtar Kelimeler

Pregnancy, Ectopic, Methotrexate, Neutrophils, Lymphocytes, Blood Platelets

Kaynakça

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