Etilenglikol zehirlenmesine bağlı gelişen akut böbrek yetmezliği

Yıl 2016, Cilt: 6 Sayı: 1, 67 - 69, 19.10.2016

İhsan Ateş Nihal Ozkayar Nergiz Bayrakci Fatih Dede

https://doi.org/10.16899/ctd.81523

Öz

Etilenglikol, dihidrik alkoller grubundan, renksiz, kokusuz, tatlı ve suda çözünen bir maddedir. Etilenglikol içeren maddelerin kaza ya da intihar amaçlı alınması sonucu ağır

metabolik asidoz, santral sinir sistemi depresyonu ve oligürik akut böbrek yetmezliği meydana gelir. Erken tanı ve tedavi ile mortalite anlamlı bir düzeyde azalabilmektedir. Biz kaza ile antifriz içtikten sonra etilenglikol zehirlenmesine bağlı olarak ağır metabolik asidoz, koma ve akut böbrek yetmezliği tablosu gelişmiş bir vakayı sunduk. 

Anahtar Kelimeler

Akut böbrek yetmezliği, Etilenglikol zehirlenmesi, Metabolik asidoz

Acute Renal Failure Due To Ethyleneglycol Poisoning

Öz

Ethylene glycol is a colorless, odorless, sweet, water-soluble substance from the group of dihydric alcohols. As a result of taking ethylene-containing material for suicide purpose or as an accident, serious metabolic acidosis, central nervous system depression and oliguric acute renal failure occur. Early diagnosis and treatment can reduce mortality at a significant level. We present a case with severe metabolic acidosis, coma and acute renal failure due to ethylene glycol intoxication after drinking antifreeze accidentally.

Anahtar Kelimeler

Acute renal failure, Ethylene glycol poisoning, Metabolic acidosis

Kaynakça

• Jacobsen D and McMartin KE, Antidotes for methanol and ethylene glycol poisoning. J Toxicol Clin Toxicol, 1997. 35(2): p. 127-43.
• Jacobsen D and McMartin KE, Methanol and ethylene glycol poisonings. Mechanism of toxicity, clinical cour- se, diagnosis and treatment. Med Toxicol, 1986. 1(5): p. 309-34.
• Roscher AA, A new histochemical method for the de- monstration of calcium oxalate in tissues following ethylene glycol poisoning. Am J Clin Pathol, 1971. 55(1): p. 99-104.
• Brent J, Current management of ethylene glycol poiso- ning. Drugs, 2001. 61(7): p. 979-88.
• Caravati EM, Erdman AR, Christianson G, et al., Eth- ylene glycol exposure: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila), 2005. 43(5): p. 327-45.
• Barceloux DG, Krenzelok EP, Olson K, et al., American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee. J Toxicol Clin Toxicol, 1999. 37(5): p. 537- 60.
• Brent J, McMartin K, Phillips S, et al., Fomepizole for the treatment of ethylene glycol poisoning. Methyl- pyrazole for Toxic Alcohols Study Group. N Engl J Med, 1999. 340(11): p. 832-8.