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Prescribing trends of non-steroidal anti-inflammatory drugs in a tertiary care hospital in the middle Anatolia

Yıl 2017, Cilt: 7 Sayı: 3, 203 - 207, 30.09.2017
https://doi.org/10.16899/gopctd.349789

Öz

Background: Non-steroidal anti-inflammatory (NSAI) drugs are widely used for their analgesic, antipyretic and antiinflammatory effects. The aim of this study is to evaluate the prescribing trends of NSAI drugs among the doctors working the outpatients clinics in our hospital.

Materials and methods: Questionnaires consisting of 10 questions related to analgesic and NSAI drug preferences were applied to the doctors working the medical and surgery outpatient clinics in a tertiary care hospital in the Middle Anatolia, and data was collected.

Results: The frequency of prescription of NSAI drug in our hospital were found 34,5%. In the internal and surgical departments, respectively, most often diclofenac (23.1%) and dexketoprofen (43.5%) were being prescribed. The most frequent cause of prescribing was joint pain (57,7%) in the internal departments and postoperative pain (73,9%) in the surgical departments. 

Conclusion: Unnecessary use of NSAI drugs should be avoided because of the high side effect risk despite it's efficacy and benefits and our knowledge of these drugs we prescribe frequently must be updated.


Kaynakça

  • 1. Hasçelik Z. Nonsteroid antiinflamatuvar ilaçlar. Sürekli Tıp Eğitimi Dergisi. 2001; 10: 1.
  • 2. Wallace JL. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology. 1997;112(3):1000-1016.
  • 3. Vane J, Flower R, Botting R. History of aspirin and its mechanism of action. Stroke. 1990;21(12):IV12-IV23.
  • 4. Bacchi S, Palumbo P, Sponta A, Coppolino MF. Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2012;11(1):52-64.
  • 5. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature. 1971;231(25):232-235.
  • 6. Green GA. Understanding NSAIDs: from aspirin to COX-2. Clinical cornerstone. 2001;3(5):50-59.
  • 7. Keys J, Beardon P, Jau C, Lang C, McDevitt D. General practitioners' use of non-steroidal anti-inflammatory drugs in Tayside and Fife regions. Journal of the Royal Society of Medicine. 1992;85(8):442-445.
  • 8. Stickel F. Agents and drugs: precautions in patients with cirrhosis. Cirrhosis: A practical guide to management. 2015:261.
  • 9. Laine L. The gastrointestinal effects of nonselective NSAIDs and COX-2-selective inhibitors. Seminars in arthritis and rheumatism. 2002 Dec;32(3 Suppl 1):25-32.
  • 10. Whelton A. Renal aspects of treatment with conventional nonsteroidal anti-inflammatory drugs versus cyclooxygenase-2-specific inhibitors. The American journal of medicine. 2001 Feb 19;110 Suppl 3A:33S-42S.
  • 11. Trelle S, Reichenbach S, Wandel S, Hildebrand P, Tschannen B, Villiger PM, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ (Clinical research ed). 2011;342:c7086.
  • 12. Stovitz SD, Johnson RJ. NSAIDs and musculoskeletal treatment: what is the clinical evidence? The Physician and Sportsmedicine. 2003;31(1):35-52.
  • 13. Alamchandani R, Sattigeri B, Karelia P. A comparative survey study on current prescribing trends in non-steroidal anti-inflammatory drugs among practitioners in private set up and tertiary care teaching rural hospital. International Journal of Research in Medical Sciences. 2014;2(4):1672-1675.
  • 14. Clissold SP. Paracetamol and phenacetin. Drugs. 1986;32(4):46-59.
  • 15. Kutsal Y, Varlı K, Çeliker R, Özer S, Orer H, Aypar Ü, et al. Ağrıya multidisipliner yaklaşım. Hacettepe Tıp Dergisi. 2005;36(2):111-128.
  • 16. Miyoshi H. Systemic nonopioid analgesics. Bonica’s management of pain. 2001:1667-1709.
  • 17. Graham GG, Scott KF. Mechanism of action of paracetamol. American journal of therapeutics. 2005;12(1):46-55.
  • 18. Gökçimen A, Malas MA. Nonsteroidal anti-inflamatuvar ilaçların gebelikteki toksisiteleri ile ilgili literatürlerin gözden geçirilmesi. SDÜ Tıp Fakültesi Dergisi. 2003;10(3).
  • 19. Ostensen ME, Skomsvoll JF. Anti-inflammatory pharmacotherapy during pregnancy. Expert opinion on pharmacotherapy. 2004;5(3):571-580.
  • 20. Cervera R, Balasch J. The management of pregnant patients with antiphospholipid syndrome. Lupus. 2004;13(9):683-687.
  • 21. Şavlı E. Gebelikte parasetamol kullanımı. Journal of Experimental and Clinical Medicine. 2012;29(2).
  • 22. Derle D, Gujar K, Sagar B. Adverse effects associated with the use of nonsteroidal antiinflammatory drugs: An overview. Indian journal of pharmaceutical sciences. 2006;68(4):409.
  • 23. Laine L. Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient. Gastroenterology. 2001;120(3):594-606.
  • 24. Lanza FL, Chan FK, Quigley EM. Guidelines for prevention of NSAID-related ulcer complications. The American journal of gastroenterology. 2009;104(3):728-738.

Orta Anadoluda Üçüncü Basamak Bir Hastanede Non-Steroid Anti-İnflamatuar İlaç Reçeteleme Tercihleri

Yıl 2017, Cilt: 7 Sayı: 3, 203 - 207, 30.09.2017
https://doi.org/10.16899/gopctd.349789

Öz

Giriş: Non-Steroid Anti-inflamatuar (NSAİ) ilaçlar analjezik, antipiretik ve antiinflamatuar etkileri nedeniyle yaygın olarak kullanılan ilaçlardır. Çalışmanın amacı hastanemizde poliklinik hizmeti veren doktorlarımızın NSAİ ilaç reçeteleme alışkanlıklarını ve tercihlerini gözden geçirmektir.

Gereç ve yöntem: İç Anadolu’da üçüncü basamak bir hastanede dahili ve cerrahi branşlarda çalışan ve poliklinik hizmeti veren doktorlarımıza ağrı kesici ve NSAİ ilaç tercihleri ile ilişkili 10 sorudan oluşan anket uygulanmış ve veriler toplanmıştır.

Bulgular: Hastanemizde NSAİ ilaç reçete etme sıklığı %34,5 saptandı. Dahili ve cerrahi bölümlerde sırasıyla en sık diklofenak (%23,1) ve deksketoprofen (%43,5) reçete edilmekte idi. En sık reçeteleme sebebi dahili branşlarda eklem ağrısı (%57,7), cerrahi branşlarda ise postoperatif ağrı (%73,9), en sık karşılaşılan yan etki ise gastrointestinal sistem yakınmaları idi. 

Sonuç: Yüksek etkinliği ve faydaları yanında yan etki riski de yüksek olan NSAİ ilaçların gereksiz kullanımından kaçınılmalı ve çok sık reçetelediğimiz bu ilaçlar konusundaki bilgilerimiz güncellenmelidir.


Kaynakça

  • 1. Hasçelik Z. Nonsteroid antiinflamatuvar ilaçlar. Sürekli Tıp Eğitimi Dergisi. 2001; 10: 1.
  • 2. Wallace JL. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology. 1997;112(3):1000-1016.
  • 3. Vane J, Flower R, Botting R. History of aspirin and its mechanism of action. Stroke. 1990;21(12):IV12-IV23.
  • 4. Bacchi S, Palumbo P, Sponta A, Coppolino MF. Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2012;11(1):52-64.
  • 5. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature. 1971;231(25):232-235.
  • 6. Green GA. Understanding NSAIDs: from aspirin to COX-2. Clinical cornerstone. 2001;3(5):50-59.
  • 7. Keys J, Beardon P, Jau C, Lang C, McDevitt D. General practitioners' use of non-steroidal anti-inflammatory drugs in Tayside and Fife regions. Journal of the Royal Society of Medicine. 1992;85(8):442-445.
  • 8. Stickel F. Agents and drugs: precautions in patients with cirrhosis. Cirrhosis: A practical guide to management. 2015:261.
  • 9. Laine L. The gastrointestinal effects of nonselective NSAIDs and COX-2-selective inhibitors. Seminars in arthritis and rheumatism. 2002 Dec;32(3 Suppl 1):25-32.
  • 10. Whelton A. Renal aspects of treatment with conventional nonsteroidal anti-inflammatory drugs versus cyclooxygenase-2-specific inhibitors. The American journal of medicine. 2001 Feb 19;110 Suppl 3A:33S-42S.
  • 11. Trelle S, Reichenbach S, Wandel S, Hildebrand P, Tschannen B, Villiger PM, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ (Clinical research ed). 2011;342:c7086.
  • 12. Stovitz SD, Johnson RJ. NSAIDs and musculoskeletal treatment: what is the clinical evidence? The Physician and Sportsmedicine. 2003;31(1):35-52.
  • 13. Alamchandani R, Sattigeri B, Karelia P. A comparative survey study on current prescribing trends in non-steroidal anti-inflammatory drugs among practitioners in private set up and tertiary care teaching rural hospital. International Journal of Research in Medical Sciences. 2014;2(4):1672-1675.
  • 14. Clissold SP. Paracetamol and phenacetin. Drugs. 1986;32(4):46-59.
  • 15. Kutsal Y, Varlı K, Çeliker R, Özer S, Orer H, Aypar Ü, et al. Ağrıya multidisipliner yaklaşım. Hacettepe Tıp Dergisi. 2005;36(2):111-128.
  • 16. Miyoshi H. Systemic nonopioid analgesics. Bonica’s management of pain. 2001:1667-1709.
  • 17. Graham GG, Scott KF. Mechanism of action of paracetamol. American journal of therapeutics. 2005;12(1):46-55.
  • 18. Gökçimen A, Malas MA. Nonsteroidal anti-inflamatuvar ilaçların gebelikteki toksisiteleri ile ilgili literatürlerin gözden geçirilmesi. SDÜ Tıp Fakültesi Dergisi. 2003;10(3).
  • 19. Ostensen ME, Skomsvoll JF. Anti-inflammatory pharmacotherapy during pregnancy. Expert opinion on pharmacotherapy. 2004;5(3):571-580.
  • 20. Cervera R, Balasch J. The management of pregnant patients with antiphospholipid syndrome. Lupus. 2004;13(9):683-687.
  • 21. Şavlı E. Gebelikte parasetamol kullanımı. Journal of Experimental and Clinical Medicine. 2012;29(2).
  • 22. Derle D, Gujar K, Sagar B. Adverse effects associated with the use of nonsteroidal antiinflammatory drugs: An overview. Indian journal of pharmaceutical sciences. 2006;68(4):409.
  • 23. Laine L. Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient. Gastroenterology. 2001;120(3):594-606.
  • 24. Lanza FL, Chan FK, Quigley EM. Guidelines for prevention of NSAID-related ulcer complications. The American journal of gastroenterology. 2009;104(3):728-738.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Orjinal Çalışma
Yazarlar

Elif Börekçi Bu kişi benim

Yayımlanma Tarihi 30 Eylül 2017
Kabul Tarihi 23 Mart 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 7 Sayı: 3

Kaynak Göster

APA Börekçi, E. (2017). Orta Anadoluda Üçüncü Basamak Bir Hastanede Non-Steroid Anti-İnflamatuar İlaç Reçeteleme Tercihleri. Çağdaş Tıp Dergisi, 7(3), 203-207. https://doi.org/10.16899/gopctd.349789
AMA Börekçi E. Orta Anadoluda Üçüncü Basamak Bir Hastanede Non-Steroid Anti-İnflamatuar İlaç Reçeteleme Tercihleri. J Contemp Med. Kasım 2017;7(3):203-207. doi:10.16899/gopctd.349789
Chicago Börekçi, Elif. “Orta Anadoluda Üçüncü Basamak Bir Hastanede Non-Steroid Anti-İnflamatuar İlaç Reçeteleme Tercihleri”. Çağdaş Tıp Dergisi 7, sy. 3 (Kasım 2017): 203-7. https://doi.org/10.16899/gopctd.349789.
EndNote Börekçi E (01 Kasım 2017) Orta Anadoluda Üçüncü Basamak Bir Hastanede Non-Steroid Anti-İnflamatuar İlaç Reçeteleme Tercihleri. Çağdaş Tıp Dergisi 7 3 203–207.
IEEE E. Börekçi, “Orta Anadoluda Üçüncü Basamak Bir Hastanede Non-Steroid Anti-İnflamatuar İlaç Reçeteleme Tercihleri”, J Contemp Med, c. 7, sy. 3, ss. 203–207, 2017, doi: 10.16899/gopctd.349789.
ISNAD Börekçi, Elif. “Orta Anadoluda Üçüncü Basamak Bir Hastanede Non-Steroid Anti-İnflamatuar İlaç Reçeteleme Tercihleri”. Çağdaş Tıp Dergisi 7/3 (Kasım 2017), 203-207. https://doi.org/10.16899/gopctd.349789.
JAMA Börekçi E. Orta Anadoluda Üçüncü Basamak Bir Hastanede Non-Steroid Anti-İnflamatuar İlaç Reçeteleme Tercihleri. J Contemp Med. 2017;7:203–207.
MLA Börekçi, Elif. “Orta Anadoluda Üçüncü Basamak Bir Hastanede Non-Steroid Anti-İnflamatuar İlaç Reçeteleme Tercihleri”. Çağdaş Tıp Dergisi, c. 7, sy. 3, 2017, ss. 203-7, doi:10.16899/gopctd.349789.
Vancouver Börekçi E. Orta Anadoluda Üçüncü Basamak Bir Hastanede Non-Steroid Anti-İnflamatuar İlaç Reçeteleme Tercihleri. J Contemp Med. 2017;7(3):203-7.