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ANALYSIS OF ANGIOTENSIN CONVERTING ENZYME (ACE) GENE INSERTION/DELETION(I/D)POLYMORPHISM IN MIGRAINE

Yıl 2013, Cilt: 3 Sayı: 1, 7 - 11, 01.03.2013

Öz

Migraine is a neurovascular disorder with a prevalence of around 12%, the women being more frequently affected than men. Some studies have shown that migraine may have a major genetic component. Angiotensin-converting enzyme (ACE), a key part of the renin-angiotensin system, is expressed in vascular endothelial cells and can regulate blood pressure by mediating potent vasoconstrictors and dilators. This makes angiotensin converting enzyme a plausible candidate gene for involvement in migraine pathophysiology. We aimed to study the relationship between the ACE gene and migraine pathophysiology in the study. In this study, we studied the frequency of the angiotensin converting enzyme insertion/deletion (I/D) gene polymorphisms genotypes and allelic variants in 200 patients with migraine and 199 healthy non-migrainous controls using a Polymerase Chain Reaction (PCR). In patient groups DD genotype frequency was 35.0%, ID genotype frequency was 45.5% and II genotype frequency 19.5% (0.322). Allelic frequencies was detected 57.75% for D allele, 42.25% for I allele in patients. There were no significant differences in genotype/allele frequencies of angiotensin converting enzyme gene polymorphism between patients with migraine and controls (p=0.474). Our results show that I/D polymorphism of angiotensin converting enzyme gene is not a risk factor for migraine.

Kaynakça

  • 1- Schürks M, Rist PM, and Kurth T. MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis. Headache. 2010 April; 50(4): 588–599. (http://www.ncbi.nlm.nih.gov/pubmed/199 25624)
  • 2- Joshi G, Pradhan S, Mittal B. Role of the ACE ID and MTHFR C677T polymorphisms in genetic susceptibility of migraine in a north Indian population. Journal of the Neurological Sciences 2009;277:133–137. (http://www.ncbi.nlm.nih.gov/pubmed/190 81115)
  • 3- Lin JJ, Wang PJ, Chen CH, Yueh KC, Lin SZ, and Harn HJ. Homozygous deletion genotype of angiotensin converting enzyme confers protection agains migraine in man.Acta Neurol Taiwan 2005; 14: 120-125. (http://www.ncbi.nlm.nih.gov/pubmed/162 52613)
  • 4- Kara I, Ozkok E, Aydin M et al. Combine deffects of ACE and MMP-3 polymorphisms on migraine development. Cephalalgia. 2007;27:235. (http://www.ncbi.nlm.nih.gov/pubmed/173 81556)
  • 5- Özbey Ü, Etem E, Özel S, Berilgen MS. Is there a relation between Insertion/Deletion polymorphism of the angiotensin converting enzyme gene in patients of migraine with aura and migraine without aura in region of Eastern Turkey? Turkiye Klinikleri J Med Sci 2010; 30(2) :502-6. (http://tipbilimleri.turkiyeklinikleri.com/ab stract_57739.html)
  • 6- Turgut S. 2005. Anjiotensin dönüştürücü enzim ve I/D polimorfizmi. S.D.Ü. Tıp Fak. Derg.:12(4)/53-57. (http://edergi.sdu.edu.tr/index.php/sdutfd/a rticle/viewFile/1107/1238)
  • 7- Tronvik E, Stovner LJ, Bovim G et al. Angiotensin-convertingenzyme gene insertion/deletion polymorphism in migraine patients. BMC Neurology 2008; 8:4. (http://www.biomedcentral.com/1471- 2377/8/4)
  • 8- Alaşehirli B, Gür M, Akçalı A, Geyik S et al. Angiotensin converting enzyme gene Insertion/Deletion polymorphism in migraine patients. Turk Norol Derg 2009; 15:161- 165.(http://www.tjn.org.tr/eng/jvi.aspx?pdi r=tjn&plng=eng&un=TJN- 16046&look4=)
  • 9- Cakmak EA, Çataloluk O, Yoldaş T et al. Migraine and angiotensin-converting enzyme association in Turkish patients. The Pain Clinic 2003;Vol. 15, No. 4, pp. 473– 477.(http://www.ingentaconnect.com/cont ent/maney/tpc/2003/00000015/00000004/a rt00020)
  • 10- Schu¨rks M, Zee RYL, Buring JE, Kurth T. ACE D/I polymorphism, migraine, and cardiovasculardisease in women. Neurology 2009; 17;72(7):650-6. (http://www.ncbi.nlm.nih.gov/pubmed/192 21299)
  • 11- Kowa H, Fusayasu E, Ijiri T et al. Association of theinsertion/deletion polymorphism of the angiotensin Iconverting enzyme gene in patients of migraine with aura. Neuroscience Letters 374. 2005; 129–131. (http://www.ncbi.nlm.nih.gov/pubmed/156 44278)
  • 12- Lea RA, Ovcaric M, Sundholm J, Solyom L, MacMillan J, Griffiths LR. Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reducta se may act in combinati onto increase migraine susceptibility. Molecular Brain Research 2005; 136: 112–117. (http://www.ncbi.nlm.nih.gov/pubmed/158 93594)

MİGRENDE ANJİOTENSİN DÖNÜŞTÜREN ENZİM (ACE) İNSERSİYON/DELESYON (I/D) GEN POLİMORFİZMİNİN ANALİZİ

Yıl 2013, Cilt: 3 Sayı: 1, 7 - 11, 01.03.2013

Öz

Migren toplumun yaklaşık % 12'sini etkileyen nörovasküler bir hastalık olup, kadınlarda görülme sıklığı erkeklerden daha fazladır. Bazı çalışmalarda migrenin genetik bileşenlere sahip olabileceği bildirilmiştir. Renin anjiotensin sistemin önemli bir parçası olan Anjiotensin-dönüştürücü enzim (ACE) vasküler endotel hücrelerde ifade edilir ve güçlü vazokonstriktör ve genişletici özelliğiyle kan basıncını düzenler. Bu da anjiotensin-dönüştürücü enzimi migren patofizyolojisinde uygun aday bir gen yapar. Biz bu çalışma da anjiotensin-dönüştürücü enzim geni ve migren patofizyolojisi arasında ilişkiyi araştırmayı amaçladık. Bu çalışmada, biz anjiotensin dönüştürücü enzim insersiyon/delesyon (I/D) gen polimorfizminingenotip ve allelik değişim sıklığını 200 migren hastası ve 199 sağlıklı kontrol grubunda polimeraz zincir reaksiyonu (PCR) yöntemini kullanarak araştırdık. Hasta grubunda DD genotip sıklığı %35, ID genotip sıklığı %45.5 ve II genotip sıklığı %19.5'ti (p=0.322). Allelik sıklıklar D alleli için %57.75, I alleli için %42.25'dir. ACE I/D genotip/allelik sıklığı migren hastaları ile kontrol grubu arasında karşılaştırıldığında anlamlı bir fark bulunmadı (p=0.474). Sonuçlarımız, ACE I/D polimorfizminin, migren için bir risk faktörü olmadığını göstermektedir.

Kaynakça

  • 1- Schürks M, Rist PM, and Kurth T. MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis. Headache. 2010 April; 50(4): 588–599. (http://www.ncbi.nlm.nih.gov/pubmed/199 25624)
  • 2- Joshi G, Pradhan S, Mittal B. Role of the ACE ID and MTHFR C677T polymorphisms in genetic susceptibility of migraine in a north Indian population. Journal of the Neurological Sciences 2009;277:133–137. (http://www.ncbi.nlm.nih.gov/pubmed/190 81115)
  • 3- Lin JJ, Wang PJ, Chen CH, Yueh KC, Lin SZ, and Harn HJ. Homozygous deletion genotype of angiotensin converting enzyme confers protection agains migraine in man.Acta Neurol Taiwan 2005; 14: 120-125. (http://www.ncbi.nlm.nih.gov/pubmed/162 52613)
  • 4- Kara I, Ozkok E, Aydin M et al. Combine deffects of ACE and MMP-3 polymorphisms on migraine development. Cephalalgia. 2007;27:235. (http://www.ncbi.nlm.nih.gov/pubmed/173 81556)
  • 5- Özbey Ü, Etem E, Özel S, Berilgen MS. Is there a relation between Insertion/Deletion polymorphism of the angiotensin converting enzyme gene in patients of migraine with aura and migraine without aura in region of Eastern Turkey? Turkiye Klinikleri J Med Sci 2010; 30(2) :502-6. (http://tipbilimleri.turkiyeklinikleri.com/ab stract_57739.html)
  • 6- Turgut S. 2005. Anjiotensin dönüştürücü enzim ve I/D polimorfizmi. S.D.Ü. Tıp Fak. Derg.:12(4)/53-57. (http://edergi.sdu.edu.tr/index.php/sdutfd/a rticle/viewFile/1107/1238)
  • 7- Tronvik E, Stovner LJ, Bovim G et al. Angiotensin-convertingenzyme gene insertion/deletion polymorphism in migraine patients. BMC Neurology 2008; 8:4. (http://www.biomedcentral.com/1471- 2377/8/4)
  • 8- Alaşehirli B, Gür M, Akçalı A, Geyik S et al. Angiotensin converting enzyme gene Insertion/Deletion polymorphism in migraine patients. Turk Norol Derg 2009; 15:161- 165.(http://www.tjn.org.tr/eng/jvi.aspx?pdi r=tjn&plng=eng&un=TJN- 16046&look4=)
  • 9- Cakmak EA, Çataloluk O, Yoldaş T et al. Migraine and angiotensin-converting enzyme association in Turkish patients. The Pain Clinic 2003;Vol. 15, No. 4, pp. 473– 477.(http://www.ingentaconnect.com/cont ent/maney/tpc/2003/00000015/00000004/a rt00020)
  • 10- Schu¨rks M, Zee RYL, Buring JE, Kurth T. ACE D/I polymorphism, migraine, and cardiovasculardisease in women. Neurology 2009; 17;72(7):650-6. (http://www.ncbi.nlm.nih.gov/pubmed/192 21299)
  • 11- Kowa H, Fusayasu E, Ijiri T et al. Association of theinsertion/deletion polymorphism of the angiotensin Iconverting enzyme gene in patients of migraine with aura. Neuroscience Letters 374. 2005; 129–131. (http://www.ncbi.nlm.nih.gov/pubmed/156 44278)
  • 12- Lea RA, Ovcaric M, Sundholm J, Solyom L, MacMillan J, Griffiths LR. Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reducta se may act in combinati onto increase migraine susceptibility. Molecular Brain Research 2005; 136: 112–117. (http://www.ncbi.nlm.nih.gov/pubmed/158 93594)
Toplam 12 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Orjinal Çalışma
Yazarlar

Saime Sezer Bu kişi benim

Jülide Altınışık Bu kişi benim

Nihan Bozkurt Bu kişi benim

Songül Akkanet Bu kişi benim

Hacı Ömer Ateş Bu kişi benim

Yayımlanma Tarihi 1 Mart 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 3 Sayı: 1

Kaynak Göster

APA Sezer, S., Altınışık, J., Bozkurt, N., Akkanet, S., vd. (2013). MİGRENDE ANJİOTENSİN DÖNÜŞTÜREN ENZİM (ACE) İNSERSİYON/DELESYON (I/D) GEN POLİMORFİZMİNİN ANALİZİ. Çağdaş Tıp Dergisi, 3(1), 7-11.
AMA Sezer S, Altınışık J, Bozkurt N, Akkanet S, Ateş HÖ. MİGRENDE ANJİOTENSİN DÖNÜŞTÜREN ENZİM (ACE) İNSERSİYON/DELESYON (I/D) GEN POLİMORFİZMİNİN ANALİZİ. J Contemp Med. Mart 2013;3(1):7-11.
Chicago Sezer, Saime, Jülide Altınışık, Nihan Bozkurt, Songül Akkanet, ve Hacı Ömer Ateş. “MİGRENDE ANJİOTENSİN DÖNÜŞTÜREN ENZİM (ACE) İNSERSİYON/DELESYON (I/D) GEN POLİMORFİZMİNİN ANALİZİ”. Çağdaş Tıp Dergisi 3, sy. 1 (Mart 2013): 7-11.
EndNote Sezer S, Altınışık J, Bozkurt N, Akkanet S, Ateş HÖ (01 Mart 2013) MİGRENDE ANJİOTENSİN DÖNÜŞTÜREN ENZİM (ACE) İNSERSİYON/DELESYON (I/D) GEN POLİMORFİZMİNİN ANALİZİ. Çağdaş Tıp Dergisi 3 1 7–11.
IEEE S. Sezer, J. Altınışık, N. Bozkurt, S. Akkanet, ve H. Ö. Ateş, “MİGRENDE ANJİOTENSİN DÖNÜŞTÜREN ENZİM (ACE) İNSERSİYON/DELESYON (I/D) GEN POLİMORFİZMİNİN ANALİZİ”, J Contemp Med, c. 3, sy. 1, ss. 7–11, 2013.
ISNAD Sezer, Saime vd. “MİGRENDE ANJİOTENSİN DÖNÜŞTÜREN ENZİM (ACE) İNSERSİYON/DELESYON (I/D) GEN POLİMORFİZMİNİN ANALİZİ”. Çağdaş Tıp Dergisi 3/1 (Mart 2013), 7-11.
JAMA Sezer S, Altınışık J, Bozkurt N, Akkanet S, Ateş HÖ. MİGRENDE ANJİOTENSİN DÖNÜŞTÜREN ENZİM (ACE) İNSERSİYON/DELESYON (I/D) GEN POLİMORFİZMİNİN ANALİZİ. J Contemp Med. 2013;3:7–11.
MLA Sezer, Saime vd. “MİGRENDE ANJİOTENSİN DÖNÜŞTÜREN ENZİM (ACE) İNSERSİYON/DELESYON (I/D) GEN POLİMORFİZMİNİN ANALİZİ”. Çağdaş Tıp Dergisi, c. 3, sy. 1, 2013, ss. 7-11.
Vancouver Sezer S, Altınışık J, Bozkurt N, Akkanet S, Ateş HÖ. MİGRENDE ANJİOTENSİN DÖNÜŞTÜREN ENZİM (ACE) İNSERSİYON/DELESYON (I/D) GEN POLİMORFİZMİNİN ANALİZİ. J Contemp Med. 2013;3(1):7-11.