Öz
Kolşisin Ailevi Akdeniz Ateşi, amiloidoz, akut gut artriti ve primer bilier siroz tedavisinde kullanılan iyi bilinen bir ilaçtır. Kolşisin, Colchium Autumnale bitkisinden elde edilen alkaloid bir ilaçtır. İshal, bulantı, kusma, karın ağrısı, elektrolit ve sıvının aşırı kaybı gastrointestinal yüzeyden aşırı emilen kolşisinin zehirlenme bulgularıdır. Kolşisin dar bir töropetik indekse sahip olduğundan bu ilaç ile intihar girişimi yüksek bir mortaliteye sahiptir. Kolşisin zehirlenmesi hasta için kritik ve hayatı tehdit edici olduğundan doktorlar, bu ilacın komplikasyonlarını ve aşırı doz alımında ortaya çıkacacak etkilerin farkında olmalıdır. Burada, intihar girişimi ile yüksek doz kolşisin alan bir olguyu sunmayı amaçladık
Anahtar Kelimeler
Kaynakça
- Ioulia Iosfina, James Lan,Carson Chin, Ronald Werb, Adeera Levin. Massive Colchicine Overdose with Recovery. Case Rep Nephrol Urol. 2012; 2: 20–24.
- Abdulsamet Erden, Hatice Karagoz, Hasan Hüseyin Gümüscü, Samet Karahan, Mustafa Basak, Fatma Aykas, Kadir Bulut, Ali Cetinkaya, Deniz Avci,Orhan Kürsat Poyrazoglu. Colchicine intoxication: a report of two suicide cases. Ther Clin Risk Manag. 2013; 9: 505–509.
- Maxwell MJ, Muthu P, Pritty PE. Accidental colchicine overdose. A case report and literature review. Emerg Med J. 2002;19:265-7.
- Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila). 2010;48: 407-14.
- Aghabiklooei A, Zamani N, Hassanian-Moghaddam H, Nasouhi S, Mashayekhian M. Acute colchicine overdose: report of three cases. Reumatismo. 2014;65:307-11
- Jouffroy R, Lamhaut L, Petre Soldan M, Vivien B, Philippe P, An K, Carli P. A new approach for early onset cardiogenic shock in acute colchicine overdose: place of early extracorporeal life support (ECLS) Intensive Care Med. 2013; 39:1163.
- Miran Brvar, Tom Ploj, Gordana Kozelj, Martin Mozina, Marko Noc, Matjaz Bunc. Case report: fatal poisoning with Colchicum autumnale. Crit Care. 2004; 8: 56–59.
- Brncić N, Visković I, Perić R, Dirlić A, Vitezić D, Cuculić D.Accidental plant poisoning with Colchicum autumnale: report of two cases. Croat Med J. 2001;42:673-5.
Öz
Colchicine is a well-recognized drug, that is used for the treatment of familial Mediterranean Fever, acute gout arthritis, amyloidosis and primary biliary cirrhosis. Colchicine is an alkaloid drug that is derived from Colchium autumnale.Diarrhea, sickness, vomiting, abdominal pain, excessive deficiency of electrolytes and fluid are common symptoms of intoxication due to higher absorption of colchicine from gastrointestinal surface. Colchicine has a narrow therapeutic index and suicide attempted with this drug has a higher mortality.Colchicine intoxication is a critical and life-threatening condition for patients so that pyhsicians should be aware of over dose and complications of this drug. Herein, we reported a case of colchicine overdose for suicide attempt.
Anahtar Kelimeler
Kaynakça
- Ioulia Iosfina, James Lan,Carson Chin, Ronald Werb, Adeera Levin. Massive Colchicine Overdose with Recovery. Case Rep Nephrol Urol. 2012; 2: 20–24.
- Abdulsamet Erden, Hatice Karagoz, Hasan Hüseyin Gümüscü, Samet Karahan, Mustafa Basak, Fatma Aykas, Kadir Bulut, Ali Cetinkaya, Deniz Avci,Orhan Kürsat Poyrazoglu. Colchicine intoxication: a report of two suicide cases. Ther Clin Risk Manag. 2013; 9: 505–509.
- Maxwell MJ, Muthu P, Pritty PE. Accidental colchicine overdose. A case report and literature review. Emerg Med J. 2002;19:265-7.
- Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila). 2010;48: 407-14.
- Aghabiklooei A, Zamani N, Hassanian-Moghaddam H, Nasouhi S, Mashayekhian M. Acute colchicine overdose: report of three cases. Reumatismo. 2014;65:307-11
- Jouffroy R, Lamhaut L, Petre Soldan M, Vivien B, Philippe P, An K, Carli P. A new approach for early onset cardiogenic shock in acute colchicine overdose: place of early extracorporeal life support (ECLS) Intensive Care Med. 2013; 39:1163.
- Miran Brvar, Tom Ploj, Gordana Kozelj, Martin Mozina, Marko Noc, Matjaz Bunc. Case report: fatal poisoning with Colchicum autumnale. Crit Care. 2004; 8: 56–59.
- Brncić N, Visković I, Perić R, Dirlić A, Vitezić D, Cuculić D.Accidental plant poisoning with Colchicum autumnale: report of two cases. Croat Med J. 2001;42:673-5.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 9 Nisan 2015 |
| Yayımlandığı Sayı | Yıl 2015 Cilt: 5 Sayı: 1-Ek |