Outcomes of Ozone Therapy Administered as Prophylaxis or Treatment To Health Workers During The Covid-19 Pandemic

Öz

Health employees are at high risk for COVID-19 infection. At the same time, the need for healthcare professionals has increased during the pandemic process. And it is clear that we have to protect our employees, ozone is a beneficial method which has not any side effects. Therefore, it is important to minimize the transmission risk of health employees and to support their immune systems. There are several studies demonstrating that ozone therapy supports the immune system. Moreover, ozone has proven to be highly effective in inactivating bacteria, fungi, molds and viruses both on the surfaces and suspended in the air. Ozone might be effective on coronavirus as well. In this study our findings will show protective effect of ozone on health employees. It is considered that ozone therapy is beneficial as a choice to increase protection methods and as supportive treatment for health employees. In our study, we aimed to examine the results of prophylactic or therapeutic ozone therapy which was applied to volunteer health employees during the COVID-19 pandemic.

Anahtar Kelimeler

• Coronavirus
• ozone therapy
• health employees

Sağlık Çalışanlarına Covid 19 Pandemisi Sırasında Proflaktik veya Tedavi Amaçlı Uygulanan Ozonterapinin Etkileri

Öz

Sağlık çalışanları COVID-19 enfeksiyonu için yüksek risk altındadır. Aynı zamanda pandemi sürecinde sağlık çalışanlarına olan ihtiyaç da artmıştır. Sağlık çalışanlarımızı korumamız gerekliliği kaçınılmazdır, ozon hiçbir yan etkisi olmayan faydalı bir yöntemdir. Bu nedenle sağlık çalışanlarına bulaş riskini en aza indirmek ve bağışıklık sistemlerini desteklemek önemlidir. Ozon tedavisinin bağışıklık sistemini desteklediğini gösteren birçok çalışma bulunmaktadır. Ayrıca ozonun hem yüzeylerde hem de havada asılı halde bulunan bakteri, mantar, küf ve virüsleri etkisiz hale getirmede oldukça etkili olduğu kanıtlanmıştır. Ozon, koronavirüs üzerinde de etkili olabilir. Bu çalışmada bulgularımız ozonun sağlık çalışanları üzerindeki koruyucu etkisini gösterecektir. Ozon tedavisinin, sağlık çalışanlarını koruma yöntemlerini artırmada ve destekleyici tedavi olarak faydalı olduğu düşünülmektedir. Çalışmamızda, COVID-19 pandemisi sürecinde gönüllü sağlık çalışanlarına uygulanan profilaktik veya terapötik ozon tedavisinin sonuçlarını incelemeyi amaçladık.

Anahtar Kelimeler

• Koronavirüs
• ozonterapi
• sağlık çalışanları

Destekleyen Kurum

yok

Kaynakça

1. Baki S, Piyal B. Work-Family Confl ict as Regard to Healthcare Workers in Extraordinary Situations such as COVID -19 Pandemic Health and Community- 2020; July (Suppl) 119-123.
2. Pala SÇ, Metintaş S. Healthcare Workers in the COVID-19 Pandemic. ESTUDAM Journal of Public Health. 2020;5(COVID-19 Suppl.):156-168.
3. Saatçı E. COVID-19 Pandemic and Healthcare Workers: To Survive or To Live? Turkish Journal of Family Practice 2020; 24 (3):153-166.
4. S.F. Lumley, D. O’Donnell, N.E. Stoesser, P.C. Matthews, A. Howarth, et al. Eyre, for the Oxford University Hospitals Staff Testing Group. Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers NEJM 2020; December doi: 10.1056/NEJMoa2034545
5. Elvis AM, Ekta JS. Ozone therapy: A clinical review. J Nat Sci Biol Med. 2011 Jan;2(1):66- 70. doi: 10.4103/0976-9668.82319.
6. Hernández A, Viñals M, Isidoro T, Vilás F. Potential Role of Oxygen-Ozone Th erapy in Treatment of COVID-19 Pneumonia. Am J Case Rep. 2020 Aug 17;21:e925849. doi: 10.12659/ AJCR.925849.
7. Smith NL, Wilson AL, Gandhi J, Vatsia S, Khan SA. Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res. 2017;7:212-9.
8. Rowen RJ, Robins H, Carew K, Kamara MM, Jalloh MI. et al. Rapid resolution of hemorrhagic fever (Ebola) in Sierra Leone with Ozone therapy. Afr J Infect Dis. 2016; 10 (1): 49-54.

9. Zaky S,Kamel SE,Hassan MS,Sallam NA,Shahata MA,Helal SR,et al. Preliminary results of ozone therapy as a possible treatment for patients with chronic hepatitis C. J Altern Complement Med.2011;17(3):259-63.
10. Valdenassi L, Franzini M, Ricevuti G,Rinaldi L,Galoforo AC, Tirelli U. Potentialmechanisms by which the oxygen-ozone (O2–O3) therapy could contribute to the treatment against the coronavirus COVID-19. Eur Rev Med Pharmacol Sci. 2020; 24 (8): 4059-4061
11. Dhand, NK, Khatkar MS. Statulator: An online statistical calculator. Sample Size Calculator for Comparing Two Paired Proportions. 2014. Accessed 10 November 2020 at [http:// statulator.com/SampleSize/ss2PP.html]
12. Arsham H.Two Dependent Proportions Testing [http://home.ubalt.edu/ntsbarsh/businessstat/ otherapplets/pairedprop.htm], Accessed 05.11.2020.
13. Hotchkiss RS, Opal SM. Activating Immunity to Fight a Foe - A New Path. N Engl J Med. 2020 Mar 26;382(13):1270-1272.
14. Franzini M, Valdenassi L, Ricevuti G, et al. Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported International Immunopharmacology 2020; 88 November :106879 https://doi.org/10.1016/j.intimp.2020.106879
15. Menendez-Cepero S, Zamora Z, Hernandez F. Importance of the toxicological tests in the application and safety of ozone therapy. J Ozone Th er. 2018; 2(3). doi:10.7203/ jo3t.2.3.2018.10009.
16. Rowen RJ. Ozone and oxidation therapies as a solution to the emerging crisis in infectious disease management: a review of current knowledge and experience. Med Gas Res. 2019 Oct-Dec;9(4):232237. doi: 10.4103/2045-9912.273962. PMID: 31898609.
17. Verbeek JH, Rajamaki B, Ijaz S, Sauni R, Toomey E, Blackwood B, Tikka C, Ruotsalainen JH, Kilinc Balci FS. Personal protective equipment for preventing highly infectious diseases due to exposure to contaminated body fl uids in healthcare staff . Cochrane Database Syst Rev. 2020 May 15;5:CD011621. doi: 10.1002/14651858.CD011621.pub5.
18. Zheng Z, Dong M, Hu K. A preliminary evaluation on the eff icacy of ozone therapy in the treatment of COVID-19. J Med Virol. 2020 May 21:10.1002/jmv.26040. doi: 10.1002/ jmv.26040.
19. Martínez-Sánchez G, Schwartz A, Donna VD. Potential Cytoprotective Activity of Ozone Th erapy in SARS-CoV-2/COVID-19. Antioxidants (Basel). 2020 May 6;9(5):389. doi:10.3390/antiox9050389.
20. Thorp JA, Hollonbeck SA, Viglione DD, Green PC, Hodge JR, et al. (2020) Novel therapy for COVID-19 does intravenous ozonated-saline aff ect blood and tissue oxygenation? J Gynecol Res Obstet. 2020; 6(2): 046-050. doi: 10.17352/jgro.000085
21. Schwartz A, Martínez-Sánchez G, de Lucía AM, Viana SM, Constanta AM. Complementary application of the ozonized saline solution in mild and severe patients with pneumonia COVID-19: A non-randomized pilot study. J Pharm Pharmacogn Res 2021; 9(2): 126–142.