Antiinflamatuvar Etkili Doğal Kaynaklı Bileşiklerin Potansiyel Antikanser Etkileri: Deneysel Kanıtların İncelenmesi

Yıl 2020, Cilt: 2 Sayı: 1, 6 - 10, 31.03.2020

Asuman Deveci Özkan Süleyman Kaleli

Öz

Kanser insan ömrünü kısıtlayan ve yaşam tarzı, genetik çeşitlilik, virüs enfeksiyonu ve kronik inflamasyon gibi birçok faktöre ek olarak kontrolsüz büyüme ve hücrelerin kontrolsüz yayılması ile karakterize yaşa bağlı bir hastalıktır. Kanser gelişimi karmaşıktır ve bağışıklık sisteminde görevli hücrelerin tümör tanınması ve yok edilmesinde önemli görevleri vardır. Bu nedenle kanser tedavisi için potansiyel anti-inflamatuvar ajanlar olarak doğal kaynaklı bileşiklerin kullanıldığı yeni terapötik yaklaşımların araştırılması önem kazanmaktadır. Ancak doğal kaynaklı bu bileşiklerin immün sistem üzerindeki etkisi ve bu etkiyle birlikte gösterdiği antikanser mekanizmalar halen araştırılmaya devam etmektedir. Dolayısıyla çalışmamızın amacı, kansere karşı antiinflamatuvar etki sergileyen bazı doğal kaynaklı bileşiklerin (nobiletin, kurkumin, genistein ve EGCG) gösterdiği potansiyel antikanser ve/veya koruyucu etkileri ile ilgili deneysel kanıtları ortaya koymaktır. Böylelikle yapılan çalışmalar incelenerek bu doğal bileşikler ile ilgili gelecekte yapılacak hedefe yönelik terapi gibi daha ileri ve kapsamlı çalışmalar kanserde doğal bileşik uygulamasının (geleneksel tıp olarak) hem bilimsel temelini hem de mevcut kemoterapötik ilaçlarla klinik olarak kombinasyon halindeki etkisini keşfetmek için moleküler bir yaklaşım geliştirmemize olanak sağlayacaktır.

Anahtar Kelimeler

Nobiletin, Kurkumin, Timokinon, Genistein, EGCG, Kanser

Kaynakça

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