Geri Çekildi: The Relationship Between Propionic Acid and Autism Spectrum Disorder

Yıl 2023, Cilt: 12 Sayı: 3, 1464 - 1473, 26.09.2023

İbrahim Hakkı Çağıran , Adviye Gülçin Sağdıçoğlu Celep

https://doi.org/10.37989/gumussagbil.1226210

Bu makale 26 Aralık 2023 tarihinde geri çekildi. https://dergipark.org.tr/tr/pub/gumussagbil/issue/81745/1376344

Öz

Autism spectrum disorder (ASD) is a compound brain development disorder of uncertain etiology and pathophysiology. In addition to environmental factors, genetic factors also affect the pathophysiology of ASD. Propionic acid (PA), which is used as a food additive and drug, can affect the genetic processes of brain development through the modulation of molecular pathways. Propionic acid causes the formation of ASD by causing mTOR/Gskβ, cytokine imbalance and disruption of developmental molecular pathways in the prenatal and neonatal period. This review was made to investigate the possible effects of PA.

Anahtar Kelimeler

Autism, Animal model, Food additive, Propionic acid.

Geri Çekildi: Propiyonik Asit ve Otizm Spektrum Bozukluğu İlişkisi

Bu makale 26 Aralık 2023 tarihinde geri çekildi. https://dergipark.org.tr/tr/pub/gumussagbil/issue/81745/1376344

Öz

Otizm spektrum bozukluğu (OSB), etiyolojisi ve patofizyolojisi belirsiz olan bileşik bir beyin gelişimi bozukluğudur. OSB patofizyolojisinde çevresel faktörlerin yanında genetik faktörler de etki etmektedir. Gıda katkı maddesi ve ilaç olarak kullanılmakta olan propiyonik asit (PA) moleküler yolların modülasyonu yoluyla beyin gelişiminin genetik süreçlerini etkileyebilmektedir. Propiyonik asit, prenatal ve neonatal dönemde mTOR/Gskβ, sitokin dengesizliğine ve gelişimsel moleküler yollarının bozulmasına neden olarak OSB’nin oluşmasına neden olur. Bu derleme, PA’nın olası etkilerini araştırmak amacıyla yapılmıştır.

Anahtar Kelimeler

Otizm, Hayvan modeli, Gıda katkı maddesi, Propiyonik asit.

Kaynakça

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