NICOTINE REPLACEMENT THERAPY DURING PREGNANCY

Öz

Smoking during and after pregnancy poses a serious risk to the health of both mother and baby. Prevalence of smoking in pregnant women in world wide was 9% -42% and 30% of pregnant women succeed in stopping smoking during pregnancy without pharmacological support. However, all experts recommend the use of nicotine replacement therapy if pregnant women do not succeed, or have previously failed in an attempt to quit.The aim of this article was reviewed in research these topic: safety ofnicotine replacement therapy during pregnancy NRT , efficiency of NRT, attitude of health professionals use of NRT, acceptability of NRT products during pregnancy

Anahtar Kelimeler

• nicotine replacement therapy during pregnancy,smoking,smoking cession,pregnancy

GEBELİKTE NİKOTİN REPLASMAN TEDAVİSİ

Öz

Gebelik boyunca ve sonrasında sigara içiminin hem anne hem de bebek sağlığı üzerine ciddi riskleri bulunmaktadır. Dünyada gebelerin sigara içme prevelansı %9-42 olmakla birlikte, bu gebelerin%30’u farmakolojik destek olmadan sigarayı bırakabilmektedir. Bununla birlikte sigarayı bırakmadabaşarısız olan veya daha önce bırakmayı denemiş ve başarısızlıkla sonuçlanmış gebelerde uzmanlar nikotin replasman tedavisinin kullanımını önermektedir. Bu makalenin amacı; gebelikte nikotin replasman tedavisinin NRT etkinliği, güvenilirliği, gebelikte NRT kullanımına sağlık çalışanlarının yaklaşımı ve gebelikte NRT nin kabul edilebilirliği ile ilgiliyapılmış çalışmaların incelenmesidir

Anahtar Kelimeler

• gebelikte nikotin replasman tedavisi,sigara içme,sigarayı bırakma,gebelik

Kaynakça

1. Bonollo, D.P; Zapka, J.G; Stoddard, A.M et al (2002) Treating nicotine dependence during preg- nancy and postpartum: understanding clinician knowledge and performance, Patient Educ Couns Dec 48(3), 265-74.
2. Borgne, A; Grange, G (2003) How can we help pregnant women stop smoking?, J Gynecol Obstet Biol Reprod (Paris) Feb 32(1 Suppl), 1S41-5.
3. Boshier, A; Wilton, L.V; Shakir, S.A (2003) Evaluation of the safety of bupropion (Zyban) for smoking cessation from experience gained in ge- neral practice use in England in 2000, Eur J Clin Pharmacol. Dec 59(10),767-73.
4. Chan, B; Einarson, A; Koren, G (2005) Effec- tiveness of bupropion for smoking cessation du- ring pregnancy., J Addict Dis 24(2),19-23.
5. Coleman, T; Antoniak, M; Britton, J et al (2004) Recruiting pregnant smokers for a place- bo-randomised controlled trial of nicotine repla- cement therapy, BMC Health Serv Res 4(1), 29.
6. Coleman, T; Britton, J; Thornton, J (2004) Ni- cotine replacement therapy in pregnancy, BMJ Apr 24, 328(7446):965-6.
7. Coleman, T; Thornton, J; Britton, J et al (2007) Protocol for the smoking, nicotine and pregnancy (SNAP) trial: double-blind, placebo- randomised, controlled trial of nicotine replace- ment therapy in pregnancy, BMC Health Serv Res Jan 3, 7:2.
8. Dempsey, D; Jacob, P; Benowitz, N.L (2002) Accelerated metabolism of nicotine and cotinine in pregnant smokers, J Pharmacol Exp Ther May 301(2), 594-8.

9. Dempsey, D.A; Benowitz, NL (2001) Risks and benefits of nicotine to aid smoking cessation in pregnancy, Drug Saf 24(4), 277-322.
10. Dubois, G (2005) Should the cost of smoking cessation aids with recognized efficacy be reim- bursed? J Gynecol Obstet Biol Reprod (Paris) 34(1), 339-43.
11. Fontaine, B (2005) Smoking and breastfee- ding: how can we help mothers stop smoking?, J Gynecol Obstet Biol Reprod (Paris 34 (1), 209- 12.
12. George, L; Granath, F; Johansson, A.L et al (2006) Self-reported nicotine exposure and plas- ma levels of cotinine in early and late pregnancy, Acta Obstet Gynecol Scand 85(11),1331-7.
13. Ginzel, K.H; Maritz, G.S; Marks, D.F et al (2007) Critical review: nicotine for the fetus, the infant and the adolescent?, J Health Psychol Mart 12(2), 215-24.
14. Griffiths, A.N, Woolley, J.L; Avasarala, S et al(2005) Survey of antenatal women’s knowledge of maternal and fetal risks of tobacco smoking and acceptability of nicotine replacement products in pregnancy, J Obstet Gynaecol Jul 25(5),432-4.
15. Haug, N.A; Stitzer, M.L; Svikis; D.S (2001) Smoking during pregnancy and intention to quit: a profile of methadone-maintained women, Nico- tine Tob Res Nov 3(4), 333-9.
16. Hegaard HK, Kjaergaard H, Moller LF, et al Multimodal intervention raises smoking cessation rate during pregnancy. Acta Obstet Gynecol Scand. 2003 Sep;82(9):813-9.
17. Heilbronner, C; Berlin, I (2005) Nicotine rep- lacement therapies during pregnancy: what do we know about the balance between benefits and risks?, J Gynecol Obstet Biol Reprod (Paris) Nov 34(7 Pt 1), 679-86.
18. Herbert, R; Coleman, T; Britton, J (2005) U.K. general practitioners’ beliefs, attitudes, and repor- ted prescribing of nicotine replacement therapy in pregnancy, Nicotine Tob Res Aug 7(4), 541-6.
19. Iversen, O.E; Hafstad, A(1996) Non-smoking policies and practices in Norwegian delivery units in 1994, Tob Control Summer 5(2),139-41.
20. Jimenez, R.C.A (2006) Nicotine replacement therapy during pregnancy, Arch Bronconeumol Aug 42(8), 404-9.
21. Jorenby, D.E (1998) New developments in ap- proaches to smoking cessation, Curr Opin Pulm Med Mar 4(2),103-6.
22. Kotlyar, M; Hatsukami, D.K (2002) Managing nicotine addiction, J Dent Educ Sep 66(9), 1061- 73.
23. Lancaster, T;Stead, L; Shepperd, S (2001) Helping parents to stop smoking: which interven- tions are effective?, Paediatr Respir Rev Sep 2(3), 222-6.
24. Le Faou, AL (2005) Public health measures studied in order to reduce antenatal exposure to tobacco: review of literature, J Gynecol Obstet Bi- ol Reprod (Paris) Apr 34 Spec No 1:3S, 470-80.
25. Le Houezec, J (2005) What smoking cessation interventions are effective in pregnant women?, J Gynecol Obstet Biol Reprod (Paris) Apr 34 Spec No 1:3S, 182-93.
26. McNeill, A; Foulds, J; Bates, C (2001) Regu- lation of nicotine replacement therapies (NRT): a critique of current practice, Addiction Dec, 96(12),1757-68.
27. Molyneux, A (2004) Nicotine replacement therapy, BMJ Feb 21, 328(7437), 454-6.
28. Pedersen, S.T; Christensen, H.R; Dossing, M (2002) Treatment of nicotine addiction. Drug the- rapy for smoking cessation, Ugeskr Laeger Mar 11,164(11),1480-4.
29. Peters, M.J; Morgan, L.C (2002) The pharma- cotherapy of smoking cessation, Med J Aust. May 20, 176(10), 486-90.
30. Price, J.H; Jordan, T.R; Dake, J.A (2006a) Obstetricians and gynecologists’ perceptions and use of nicotine replacement therapy, J Community Health Jun, 31(3),160-75.
31. Price, J.H; Jordan T.R; Dake J.A(2006b). Per- ceptions and use of smoking cessation in nurse- midwives’ practice, .J Midwifery Womens Health May-Jun, 51(3), 208-15.
32. Prignot, J; Bartsch, P; Vermeire, P et al (2000) Physician’s involvement in the smoking cessation process of their patients. Results of a 1998 survey among 4,643 Belgian physicians, Acta Clin Belg Sep-Oct 55(5), 266-75.
33. Pollak KI, Oncken CA, Lipkus IM, et al. Chal- lenges and solutions for recruiting pregnant smo- kers into a nicotine replacement therapy trial. Ni- cotine Tob Res. 2006 Aug;8(4):547-54.
34. Pullon, S; Webster, M; McLeod, D et al (2004) Smoking cessation and nicotine replacement the- rapy in current primary maternity care, Aust Fam Physician Jan-Feb 33(1-2), 94-6.
35. Rayburn, W.F; Bogenschutz, M.P (2004) Pharmacotherapy for pregnant women with addic- tions, Am J Obstet Gynecol Dec 191(6), 1885-97.
36. Scalera, A; Koren, G (1998) Rationale for treating pregnant smokers with nicotine patches. Can Fam Physician Aug 44, 1601-3.
37. Schroeder, D.R; Ogburn, P.L; Hurt, R.D et al (2002). Nicotine patch use in pregnant smokers: smoking abstinence and delivery outcomes, J Ma- tern Fetal Neonatal Med Feb 11(2), 100-7.
38. Oncken, C.A; Kranzler, H.R (2003) Pharma- cotherapies to enhance smoking cessation during pregnancy, Drug Alcohol Rev Jun 22(2), 191-202.
39. Oncken, C.A; Pbert ,L; Ockene, J.K et al (2000) Nicotine replacement prescription practi- ces of obstetric and pediatric clinicians, Obstet Gynecol Aug 96(2), 261-5.
40. Oncken, C.A; Hardardottir, H; Hatsukami, D.K, et al (1997) Effects of transdermal nicotine or smoking on nicotine concentrations and mater- nal-fetal hemodynamics, Obstet Gynecol Oct 90(4 Pt 1), 569-74
41. Oncken, C.A; Hatsukami, D.K; Lupo, V.R et al (1996) Effects of short-term use of nicotine gum in pregnant smokers, Clin Pharmacol Ther Jun 59(6), 654-61
42. Ussher, M; West, R (2003) Interest in nicotine replacement therapy among pregnant smokers, Tob Control Mar 12(1), 108-9.
43. Walsh, R.A; Lowe, J.B; Hopkins, P.J (2001) Quitting smoking in pregnancy, Med J Aust Sep 7;175(6), 320-3.
44. West, R; McNeill, A; Raw, M (2000) Smoking cessation guidelines for health professionals: an update, Health Education Authority, Thorax Dec 55(12), 987-99.
45. Wisborg, K; Henriksen, T.B; Jespersen, L.B(2000) Nicotine patches for pregnant smokers: a randomized controlled study, Obstet Gynecol Dec 96(6), 967-71
46. Wright, L.N; Thorp, J.M; Kuller, J.A et al (1997) Transdermal nicotine replacement in preg- nancy: maternal pharmacokinetics and fetal ef- fects, Am J Obstet Gynecol May 176(5), 1090-4