The Potential Role of Plant-Derived Ziziphora tenuior Extract in the Treatment of Endometrial Cancer
Öz
In recent years, there has been a growing interest in the potential effects of plant-derived compounds in cancer treatment. Within this context, Ziziphora tenuior (Z. tenuior), known for its antioxidant, antimicrobial, and antiproliferative properties, has emerged as a notable medicinal plant. This study aimed to evaluate the cytotoxic effects of Z. tenuior extract and its influence on the colony-forming ability of Ishikawa cells, a human endometrial cancer cell line. Cell viability was assessed using the CCK8 assay, followed by colony formation assays to investigate long-term proliferative effects. Treatment with various concentrations of Z. tenuior extract revealed a dose-dependent cytotoxic response. The highest level of cell death was observed at a specific time point, and the corresponding extract concentration significantly suppressed cell proliferation. Moreover, colony formation assays demonstrated a marked reduction in the clonogenic capacity of Z. tenuior-treated cells compared to the control group. These findings indicate that Z. tenuior extract exerts both short- and long-term antiproliferative effects on endometrial cancer cells in a dose-dependent manner. The results suggest that Z. tenuior may serve as a promising plant-based therapeutic agent for the treatment of various cancers, particularly hormone-dependent malignancies.
Anahtar Kelimeler
Endometrial cancer, Ziziphora tenuior, Ishikawa cells, Antiproliferative activity, Wnt/β-catenin
Kaynakça
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