The Impact of Probiotic Intervention during Developmental Cafeteria Diet Consumption on Social Behavior in Adulthood
Öz
This study examines the ramifications of consuming a cafeteria diet during developmental stages and subsequent probiotic therapy on social behavior in adult male Wistar rats. The investigation involves four experimental groups: a control group, a probiotics-only group, a cafeteria diet group, and a cafeteria diet with probiotics supplementation group. From day 21 (weaning) today 56 (the end of the developmental period), the treatments were administered. Social behavior was assessed using a three-chambered apparatus to evaluate the time spent interacting with unfamiliar rats. The results displayed that consuming a cafeteria diet during development significantly altered social behaviors, as demonstrated by decreased interaction times with unfamiliar animals, which suggests increased anxiety or diminished sociability. Conversely, the probiotics-supplemented group, which consumed the cafeteria diet, displayed social behaviors that were more comparable to the cafeteria diet group. These findings indicate that a poor diet during critical growth periods can have detrimental effects on social interaction and suggest that probiotic supplementation may be able to mitigate these negative consequences. The study emphasizes the importance of early dietary interventions and gut microbiota modulation in maintaining social health and reducing the long-term consequences of an unhealthy diet.
Anahtar Kelimeler
Cafeteria diet, SCD Probiotics, Development period, Social behavior test
Etik Beyan
The study was approved by the Bingöl University Animal Experiments Local Ethics Committee (meeting date: 29.06.2021, approval number: 2021/03).
Kaynakça
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