The Impact of Probiotic Intervention during Developmental Cafeteria Diet Consumption on Social Behavior in Adulthood

Yıl 2024, , 67 - 74, 27.10.2024

Hikmet Taner Teker , Gizem Hazan Akçay , Şeyma Nur Çetiner Aydoğan Bora Taha Ceylani

https://doi.org/10.5281/zenodo.13996497

Öz

This study examines the ramifications of consuming a cafeteria diet during developmental stages and subsequent probiotic therapy on social behavior in adult male Wistar rats. The investigation involves four experimental groups: a control group, a probiotics-only group, a cafeteria diet group, and a cafeteria diet with probiotics supplementation group. From day 21 (weaning) today 56 (the end of the developmental period), the treatments were administered. Social behavior was assessed using a three-chambered apparatus to evaluate the time spent interacting with unfamiliar rats. The results displayed that consuming a cafeteria diet during development significantly altered social behaviors, as demonstrated by decreased interaction times with unfamiliar animals, which suggests increased anxiety or diminished sociability. Conversely, the probiotics-supplemented group, which consumed the cafeteria diet, displayed social behaviors that were more comparable to the cafeteria diet group. These findings indicate that a poor diet during critical growth periods can have detrimental effects on social interaction and suggest that probiotic supplementation may be able to mitigate these negative consequences. The study emphasizes the importance of early dietary interventions and gut microbiota modulation in maintaining social health and reducing the long-term consequences of an unhealthy diet.

Anahtar Kelimeler

Cafeteria diet, SCD Probiotics, Development period, Social behavior test

Etik Beyan

The study was approved by the Bingöl University Animal Experiments Local Ethics Committee (meeting date: 29.06.2021, approval number: 2021/03).

Gelişim Döneminde Kafeterya Diyeti ile Probiyotik Kullanımının Ergin Bireyde Sosyal Davranış Üzerindeki Etkisi

Öz

Bu çalışma, gelişim dönemlerinde tüketilen bir cafeteria diyetinin ve ardından uygulanan probiyotik tedavisinin yetişkin erkek Wistar sıçanlarında sosyal davranışlar üzerindeki etkilerini incelemektedir. Araştırma, dört deneysel grup içermektedir: bir kontrol grubu, yalnızca probiyotik verilen bir grup, cafeteria diyeti grubu ve probiyotik ile takviye edilmiş cafeteria diyeti grubu. Tedaviler, gün 21'den (sütten kesilme) gün 56'ya (gelişim döneminin sonu) kadar uygulanmıştır. Sosyal davranışlar, deney hayvanlarının yabancı sıçanlarla etkileşimde bulundukları zamanı değerlendirmek için üç bölmeli bir düzenek kullanılarak değerlendirilmiştir. Sonuçlar, gelişim döneminde tüketilen cafeteria diyetinin sosyal davranışları önemli ölçüde değiştirdiğini ve yabancı hayvanlarla etkileşim sürelerinin azalmasıyla kendini gösterdiğini ortaya koymuştur; bu durum artan kaygı veya azalan sosyallik olarak yorumlanabilir. Buna karşın, probiyotik takviyesi yapılan ve cafeteria diyeti tüketen grup, sosyal davranışlarda cafeteria diyeti grubuna daha benzer davranışlar sergilemiştir. Bu bulgular, kritik büyüme dönemlerinde kötü bir diyetin sosyal etkileşimler üzerinde olumsuz etkileri olabileceğini ve probiyotik takviyesinin bu olumsuz sonuçları hafifletebileceğini göstermektedir. Çalışma, erken dönem diyet müdahalelerinin ve bağırsak mikrobiyotasının düzenlenmesinin sosyal sağlığı korumada ve sağlıksız bir diyetin uzun vadeli sonuçlarını azaltmada önemini vurgulamaktadır.

Anahtar Kelimeler

Kafeterya diyeti, SCD Probiotics, Gelişim dönemi, Sosyal davranış testi

Kaynakça

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