Spleen Toxicity Assessment of Propanil Exposure in Swiss Albino Mice

Yıl 2024, , 161 - 169, 01.07.2024

Ozlem Cakici Esra Akat

https://doi.org/10.15671/hjbc.1260243

Öz

Pesticides or their metabolites may have the capacity to disturb and hinder the functions of some essential organs including spleen. This study examined side effects of propanil on the spleen of mice. Experimental groups were exposed to propanil through oral administration for 30 consecutive days. The separation of capsule from the splenic parenchyma, a thickening of the capsule, congestion in the splenic parenchyma, dilated sinusoids, and arteriolar enlargement, karyolysis in megakaryocytes and amyloid formation were determined in the low-dose group. Hemorrhage and separation in the capsule, amorphous megakaryocytes, karyolysis in megakaryocytes, congestion in the splenic tissue and sinusoidal enlargement, fibrosis, lobule formation, enlargement of the white pulp and deformation of arteriole were detected in the medium-dose group. Hemorrhage in separated capsule, karyolysis in megakaryocytes, congestion in the splenic parenchyma, enlargement of the white pulp, fibrosis, necrosis in the white pulp, congestion in the enlarged sinusoid and cellular swelling in the splenic red pulp were observed in the high-dose group. These findings clearly demonstrated that propanil induced important dose-related histopathological damages. Based on our results, we can clearly say that it may have the capacity to cause this organ’ failure.

Anahtar Kelimeler

Mice, spleen, propanil, herbicide, histopathology

İsviçre Albino Farelerinde Propanil Maruziyetinin Dalak Toksisitesi Değerlendirmesi

Öz

Pestisitler veya metabolitleri, dalak dahil olmak üzere bazı temel organların fonksiyonlarını bozma ve engelleme kapasitesine sahip olabilir. Bu çalışmada, propanilin farelerin dalakları üzerindeki yan etkileri incelenmiştir. Deney grupları, ard arda 30 gün boyunca oral uygulama yoluyla propanile maruz bırakıldı. Düşük doz grubunda kapsülün dalak parankiminden ayrılması, kapsülde kalınlaşma, dalak parankiminde konjesyon, genişlemiş sinüzoidler ve arteriyolar genişleme, megakaryositlerde karyoliz ve amiloid oluşumu saptandı. Orta doz grubunda hemoraji ve kapsülde ayrılma, amorf megakaryositler, megakaryositlerde karyoliz, dalak dokusunda konjesyon ve sinüzoidal genişleme, fibrozis, lobül oluşumu, beyaz pulpada genişleme ve arteriol deformasyonu saptandı. Yüksek doz grubunda ayrılmış kapsülde kanama, megakaryositlerde karyoliz, dalak parankiminde konjesyon, beyaz pulpada genişleme, fibrozis, beyaz pulpada nekroz, genişlemiş sinüzoidde konjesyon ve dalak kırmızı pulpasında hücresel şişkinlik gözlendi. Bu bulgular, propanilin doza bağlı önemli histopatolojik hasarları uyardığını açıkça göstermiştir. Elde ettiğimiz sonuçlara göre propanilin dalak yetmezliğine yol açabilecek kapasiteye sahip olabileceğini net bir şekilde söyleyebiliriz.

Anahtar Kelimeler

Fare, dalak, propanil, herbisit, histopatoloji

Kaynakça

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