Cytotoxic Effects of Thiazolo[3,2-C]Pyrimidines Against Mcf-7 And Hepg2/C3a Carcinoma Cell Lines

Year 2018, Volume: 46 Issue: 2, 237 - 246, 03.06.2018

Arzu Birinci Yıldırım Esra Mutlu Muhammet Yıldırım

Abstract

I
n the present study, a series of thiazolo[3,2-c]pyrimidines (4,5) have been produced via simple and efficient
synthetic method and their in vitro cytotoxicities have been performed on human breast (MCF-7) and
hepatocellular (HEPG2/C3A) adenocarcinoma cell lines. The results of these in vitro tests revealed that at
least five of thiazolo[3,2-c]pyrimidines exhibited strong cytotoxic effects at very low concentrations, which
were very similar or lower than that of reference anticancer agent, 5-FU, against MCF-7 and HEPG2/C3A cancer
cell lines.

Keywords

Anticancer , breast cancer , Mannich cyclisation , thiazolopyrimidines

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