The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis

Abstract

It is known that free radicals, their products and reactive oxygen species (ROS) are associated with many diseases. The study focuses on both some changes in oxidative stress factors in patients with acute appendicitis (AA) and the changes of GST and PON1 enzyme activities in the metabolism. This study involved control group (n = 31) and the study group (n = 52). In the groups, some changes in oxidative stress factors and GST and PON1 enzyme activities which play an important role in metabolism were determined. There are changes in GST activity between study and control groups. The activity of the enzyme were significantly higher in AA groups (p < 0.01) than control. Malondialdehyde (MDA) levels in acute perforated appendicitis (PeA) groups were found significantly higher than control (p <0.01). There is a negative correlation between mean platelet volume (MPV) and lipid peroxidation in AA patients (r=-0.654, p<0.01). An increase in GSH production and GST activity provides an important defense mechanism against the oxidation of some macromolecules and may prevent oxidative stress in patients with appendicitis to some extent.

Keywords

• Oxidative stress,acute appendicitis,cellular defense system,antioxidant enzyme

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