Naproxen Derivative Interaction Properties with ct-DNA

Yıl 2019, Cilt: 47 Sayı: 2, 177 - 184, 18.09.2019

Nuriye Akbay Zeynep Koksal Tugba Taskin-tok Ayse Uzgoren-baran

https://doi.org/10.15671/hjbc.517481

Cited By: 1

Öz

Interaction mode of a naproxen derivative (NH) with ct-DNA was explored by absorption and fluorescence spectroscopy. The experimental results revealed the static quenching as a result of groove binding between the naproxen derivative and ct-DNA. Computational studies were carried out to deeper understanding of the interactions. Molecular docking calculations shown that the interaction between NH and ct-DNA is resulted by groove binding. In addition to spectral data, docking studies revealed that NH-A_DNA and NH-B_DNA complexes had different interaction and conformational trends to each DNA isomer.

Anahtar Kelimeler

Quenching, Groove binding, Naproxen, Stern-Volmer

Kaynakça

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