Antimicrobial activity of Emblica officinalis, Saraca indica and Terminalia arjuna against Multi-Drug Resistant MDR Bacterial Pathogens

Yıl 2011, Cilt: 39 Sayı: 4, 435 - 437, 01.12.2011

Rachna Gupta Pramod W. Ramteke

Öz

Plant based antimicrobials represent a vast untapped source of medicines and has enormous therapeutic potential. In the present investigation three commonly available plants were screened namely Emblica officinalis, Saraca indica and Terminalia arjuna for antimicrobial activity against four Multi-Drug Resistant MDR strains, namely Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus. Antimicrobial activity of aqueous and ethanol extracts was determined with the help of agar well diffusion method. Result showed that the ethanolic extract appears to have more antimicrobial activity in comparison to the aqueous extract and leaf extract of E.officinalis showed maximum antimicrobial activity in comparison to the leaf extracts of S.indica and T.arjuna. This study highlights that crude extracts of E. officinalis, S. indica and T. arjuna are effective against MDR pathogens. Further study on purification of active ingredient and their efficacy in controlling MDR is in progress.

Anahtar Kelimeler

Emblica officinalis, Saraca indica, Terminalia arjuna, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, antimicrobial activity

Çoklu-İlaç Dirençli Bakteriyal Patojenlere Karşı Emblica officinalis, Saraca indica ve Terminalia arjuna'nın Antimikrobiyal Aktivitesi

Öz

B itki temelli antimikrobiyal kullanılmayan muazzam bir ilaç kaynağını temsil eder ve ciddi anlamda tedavi potansiyali vardır. Bu çalışmada, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli ve Staphylococcus aureus olarak adlandırılan Çoklu-İlaç’a Dirençli dört yapıya karşı Emblica officinalis, Saraca indica ve Terminalia arjuna antimikrobiyal aktivitesi gözlendi. Sulu çözelti ve etanol özütlerinin antimikrobiyal aktivitesi katı difüzyon yöntemiyle belirlendi. Sonuçlar, etanol özütlerin sulu çözeltilere göre ve E.officinalis yaprak özütlerinin S.indica ve T.arjuna yaprak özütlerine göre daha çok antimiktobiyal aktivite gösterdiklerini ortaya koymuştur. Bu çalışmada, işlenmemiş E. officinalis, S. indica ve T. arjuna özütlerinin MDR patojenlerine karşı etkisi vurgulanmaktadır. Aktif bileşenlerin saflaştırılması ve MDR kontrolündeki etkileri ile ilgili başka çalışmalar devam etmektedir

Anahtar Kelimeler

Emblica officinalis, Saraca indica, Terminalia arjuna, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus ve antimikrobiyal aktivite

Kaynakça

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