Synthesis, Structural Characterization, and Water Solubility of a Novel Modified Poly maleic anhydride-co-vinyl acetate /Acriflavine Conjugate

Year 2016, Volume: 44 Issue: 4, 549 - 558, 01.11.2016

Gülderen Karakuş

Abstract

Novel functional poly maleic anhydride-co-vinyl acetate /acriflavine conjugate, MAVA/AF, was synthesized in two different ways that copolymer:drug ratio was designed as 1:1 and 1:2, respectively. Nontoxic poly- meric drug carrier was prepared for conjugation reaction. The purified copolymer, MAVA, was modified with an antiexternal fungal and anticancer active agent acriflavine AF at 60°C for 72 hours in dimethylformami- de DMF , using triethylamine TEA as the catalyst. Structural characterizations were carried out by Fourier Transform Infrared FTIR and Nuclear Magnetic Resonance 1H-NMR . The spectroscopic results confirmed that conjugated/modification reaction was successfully carried out by amidification reaction.

Keywords

Poly maleic anhydride-co-vinyl acetate modification, acriflavine, FTIR, NMR

Yeni Modifiye Poli maleik anhidrid-ko-vinil asetat /Akriflavin Konjugatının Sentezi, Yapısal Karakterizasyonu ve Suda Çözünürlüğü

Abstract

Y eni fonksiyonel poli maleik anhidrit-ko-vinil asetat /Akriflavin konjugatı, MAVA/AF, iki farklı yolla kopolimer:ilaç oranı sırasıyla 1:1 ve 1:2 olacak şekilde sentezlendi. Konjugasyon tepkimesi için toksik olmayan polimerik ilaç taşıyıcı hazırlandı. Saflaştırılan kopolimer, MAVA, antikanser aktif akriflavin AF ajanı ile 60°C’da 72 saat dimetilformamid DMF içinde, trietilamin TEA katalizörlüğünde modifiye edildi. Yapısal karakterizasyon Fourier Transform Infrared FTIR ve Nükleer Magnetik Rezonans 1H-NMR ile yapıldı. Spektroskopik analiz sonuçları konjugasyon/modifikasyon tepkimesinin başarılı bir şekilde amidleşme reaksiyonu ile olduğunu doğrulamaktadır

Keywords

Poli maleik anhidrid-ko-vinil asetat modifikasyonu, akriflavin, FTIR, NMR

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