BibTex RIS Kaynak Göster

The Case Study of Hemoglobin Status: Paint and Chemical Industries Workers Exposed to Organic Acid Anhydrides in S.I.T.E. Area, Kotri, Sindh, Pakistan

Yıl 2017, Cilt: 45 Sayı: 2, 245 - 249, 01.06.2017

Öz

The main objective of this study is to find an association between hemoglobin Hb and Organic acid anhydrides OAAs . The blood protein Hemoglobin Hb is influenced after an exposure to environmental hazardous OAAs compounds in paint & Chemical industry workers occupationally in SITE Area, Kotri, Sindh,Pakistan. A total of 85 workers fulfilled this research study criteria. These workers were divided into two groups like Paint industry n=40 and chemical industry n=45 workers. Both worker groups were compared with non-exposed normal group for comparative study. The hemoglobin test was done by simple and standard Kit method system on Microlab 300. The data was analysed by using SPSSversion16 software. The mean Hb for paint industry workers 11.5±1.4 and chemical industry workers 12.7±0.7 were lower than non-exposed normal 16.01±0.1 group. Thus, plasma Hb levels were significantly lower among both worker groups. There is prevalence of anemia found due to lower iron deficiency and poor socio-economic conditions among workers after prolonged harmful chemical compounds exposure.

Kaynakça

  • J.R. Delanghe, M.R. Lanlois, Haptoglobin polymorphism and body iron store, Clin. Chem. Lab. Med., 40 (2002) 212-216.
  • L.Y. Chaur, Iron and atherosclerosis, Proc. Natl Sci. Coun. Repub. China, 24 (2000) 151-555.
  • A. Hall, E. Miguel, Anemia in school children in eight countries in Africa and Asia, Public. Health. Nutr., 4 (2001) 749-756.
  • A.D.B. to pilot project to combat nutritional problems Pakistan. [Online]. 2006 Available f r om : h t t p : / / w w w. a d b . o r g / M e d i a / A r t i c l/2006/9538. Pakistan-flourfortification/default.asp.
  • World Health Organization (WHO), Worldwide prevalence of anemia, 1993–2005 (PDF). Geneva: World Health Organization. ISBN 978-92-4-159665-7 (2008).
  • R.D. Barker, J.M. Harris, J.A. Welch, K.M. Venables, A.J.N. Taylor, Occupational asthma caused by tetrachlorophthalic anhydride: a 12-year follow-up, J. Allergy. Clin. Immunol., 101 (1998) 717-719.
  • M. Kristiansson, B.A.G. Johansson, C.H. Lindh, Mass Spectrometric characterization of human hemoglobin adducts formed in vitro by Hexahydrophthalic anhydride, Chem. Res. Toxicol., 15 (2002) 562-569.
  • C.H. Lindh, B.A.G. Jonsson, Human hemoglobin 17. K.M. Venables, Low molecular weight chemicals, adducts following exposure to hexahydrophthalic anhydride and methylhexahydrophthalic anhydride, Toxicol. Appl. Pharmacol., 153 (1998) 152-160.
  • G. Johannesson, S. Rosqvist, C.H. Lindh, H. Welinder, B.A.G. Jonsson, Serum albumins are the major site for in vivo formation of hapten-carrier protein adducts in plasma from humans and guinea-pigs exposed to type- 1 allergy inducing hexahydrophthalic anhydride, Clin. Exp. Allergy., 31 (2001) 1021-1030.
  • J. Dahlin, “Aerosols of Isocynates, Amines and Anhydrides, Sweedish Anhydride Report, (2007) 52- 82.
  • CHEMSYSTEMS, Maleic anhydride, PERP Report, (2009) 07/08-8.
  • C.H. Lindh, B.A.G. Jonsson, Determination of hexahydrophthalic acid and methylhexahydrophthalic acid in plasma after derivatisation with 21. V.M. Hodges, S. Rainey, T.R. Lappin, A.P. Maxwell, pentaflurobenzyl bromide using gas chromatography and mass spectrometric detection, J. Chromatogr., 691 (1997) 331-339.
  • B.A.G. Jonsson, S. Skerfving, Toxicokinetics and biological monitoring in experimental exposure of humans to gaseous hexahydrophthalic anhydride, 23. C.B. Mathias, E.J. Freyschmidt, H.C. Oettgen, Scand. J. Work. Environ. Health., 19 (1993) 183-90.
  • S. Rosqvist, J. Nielsen, H. Welider, L. Rylander, C.H. Lindh, B.A.G. Jonsson, Exposure-response relationships for hexahydrophthalic and methylhexahydrophthalic anhydrides with total plasma protein adducts as biomarkers, Scand. J. Work. Environ. Health., 29 (2003) 297-303.
  • C.H. Lindh, B.A.G. Jonsson, G. Johannesson, X.D. Zhang, H. Welinder, E.B. Brittebo, Binding of the potent allergen hexahydrophthalic anhydride in the mucosa of the upper respiratory and alimentary tract following single inhalation exposures in guinea pigs and rats, Toxicology, 134 (1999) 153-168.
  • S. Qureshi, S.A. Memon, A.B. Ghanghro, M.F. Qureshi, M.A. Mughal, T. Qureshi, Hemoglobin adducts in paint industry workers: An electrophoretic analysis, Int. J. Adv. Life. Sci., 4 (2014) 208-215. hypersensitivity,and direct toxicity: the acid anhydrides, Brit. J. Ind. Med., 46 (1989) 222-32.
  • H. Keskinen, Cyclic acid anhydrides, The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards, 15 (2004) 1-74.
  • A.B. Ghanghro, S. Qureshi, S.A. Memon, F. Qureshi, Total serum immunoglobulin’s E levels in chemical industry workers (SITE area, Kotri, Jamshoro) exposed with organic acid anhydrides (OAAs), Brit. J. of Resear., 1 (2014) 120-23.
  • J. Jarvis, M.J. Seed, R. Elton, L. Swayer, R. Agius, Relationship between chemical structure and the occupational asthma hazard of Low molecular weight organic compounds, Occup. Envir. Med., 62 (2005) 243-250. Pathophysiology of anemia and erythrocytosis, Crit. Rev. Oncol. Hematol., 64 (2007) 139-158.
  • T.G. Janz, R.L. Johnson, S.D. Rubenstein, Anemia in the emergency department: evaluation and treatment. Emer. Med. Prac., 15 (2013) 1-15. Immunoglobulin E antibodies enhance pulmonary inflammation induced by inhalation of a chemical haptene, Clin. Exp. Allergy., 39 (2009) 417-425.

Hemoglobin Durumunun Vaka Çalışması: S.I.T.E. Bölgesi, Kotri, Sindh, Pakistan’da Boyama ve Kimyasal Endüstrisinin Çalışanlarının Organik Asit Anhidritlere Maruz Kalması

Yıl 2017, Cilt: 45 Sayı: 2, 245 - 249, 01.06.2017

Öz

B u çalışmanın temel amacı, hemoglobin Hb ve organik asit anhidritler OAA arasındaki bağlanmayı bulmaktır. SITE Area, Kotri, Sindh,Pakistan’daki boya ve kimyasal endüstrisinde çalışanların kan proteini olan hemoglobin Hb , çevre için zararlı OAA bileşiklerine maruz kaldıktan sonra etkilenir. Toplamda 85 çalışan bu araştırma çalışmasına katıldı. Bu çalışanlar boya n=40 ve kimyasal n=45 endüstri çalışanları olmak üzere ikiye bölündü. Karşılaştırma çalışması için her iki çalışan grubu maruz kalmayan normal grup ile karşılaştırıldı. Hemoglobin testi kolayca ve Microlab 300’daki standart kit metod sistemi ile yapıldı. Elde edilen sonuçlar SPSSversion16 software kullanılarak analiz edildi. Boya 11.5±1.4 ve kimyasal endüstrisininin çalışanlarının 12.7±0.7 Hb ortalaması maruz kalmayan normal gruptan 16.01±0.1 daha düşüktür. Bu nedenle, plazma Hb seviyesi her iki grup çalışanlarında da oldukça düşüktür. Bu da uzun süre zararlı kimyasal bileşiklere maruz kalan çalışanlar arasında demir eksikliği ve fakir sosyo-ekonomik durumlardan dolayı anemiyi yaygınlaştırır

Kaynakça

  • J.R. Delanghe, M.R. Lanlois, Haptoglobin polymorphism and body iron store, Clin. Chem. Lab. Med., 40 (2002) 212-216.
  • L.Y. Chaur, Iron and atherosclerosis, Proc. Natl Sci. Coun. Repub. China, 24 (2000) 151-555.
  • A. Hall, E. Miguel, Anemia in school children in eight countries in Africa and Asia, Public. Health. Nutr., 4 (2001) 749-756.
  • A.D.B. to pilot project to combat nutritional problems Pakistan. [Online]. 2006 Available f r om : h t t p : / / w w w. a d b . o r g / M e d i a / A r t i c l/2006/9538. Pakistan-flourfortification/default.asp.
  • World Health Organization (WHO), Worldwide prevalence of anemia, 1993–2005 (PDF). Geneva: World Health Organization. ISBN 978-92-4-159665-7 (2008).
  • R.D. Barker, J.M. Harris, J.A. Welch, K.M. Venables, A.J.N. Taylor, Occupational asthma caused by tetrachlorophthalic anhydride: a 12-year follow-up, J. Allergy. Clin. Immunol., 101 (1998) 717-719.
  • M. Kristiansson, B.A.G. Johansson, C.H. Lindh, Mass Spectrometric characterization of human hemoglobin adducts formed in vitro by Hexahydrophthalic anhydride, Chem. Res. Toxicol., 15 (2002) 562-569.
  • C.H. Lindh, B.A.G. Jonsson, Human hemoglobin 17. K.M. Venables, Low molecular weight chemicals, adducts following exposure to hexahydrophthalic anhydride and methylhexahydrophthalic anhydride, Toxicol. Appl. Pharmacol., 153 (1998) 152-160.
  • G. Johannesson, S. Rosqvist, C.H. Lindh, H. Welinder, B.A.G. Jonsson, Serum albumins are the major site for in vivo formation of hapten-carrier protein adducts in plasma from humans and guinea-pigs exposed to type- 1 allergy inducing hexahydrophthalic anhydride, Clin. Exp. Allergy., 31 (2001) 1021-1030.
  • J. Dahlin, “Aerosols of Isocynates, Amines and Anhydrides, Sweedish Anhydride Report, (2007) 52- 82.
  • CHEMSYSTEMS, Maleic anhydride, PERP Report, (2009) 07/08-8.
  • C.H. Lindh, B.A.G. Jonsson, Determination of hexahydrophthalic acid and methylhexahydrophthalic acid in plasma after derivatisation with 21. V.M. Hodges, S. Rainey, T.R. Lappin, A.P. Maxwell, pentaflurobenzyl bromide using gas chromatography and mass spectrometric detection, J. Chromatogr., 691 (1997) 331-339.
  • B.A.G. Jonsson, S. Skerfving, Toxicokinetics and biological monitoring in experimental exposure of humans to gaseous hexahydrophthalic anhydride, 23. C.B. Mathias, E.J. Freyschmidt, H.C. Oettgen, Scand. J. Work. Environ. Health., 19 (1993) 183-90.
  • S. Rosqvist, J. Nielsen, H. Welider, L. Rylander, C.H. Lindh, B.A.G. Jonsson, Exposure-response relationships for hexahydrophthalic and methylhexahydrophthalic anhydrides with total plasma protein adducts as biomarkers, Scand. J. Work. Environ. Health., 29 (2003) 297-303.
  • C.H. Lindh, B.A.G. Jonsson, G. Johannesson, X.D. Zhang, H. Welinder, E.B. Brittebo, Binding of the potent allergen hexahydrophthalic anhydride in the mucosa of the upper respiratory and alimentary tract following single inhalation exposures in guinea pigs and rats, Toxicology, 134 (1999) 153-168.
  • S. Qureshi, S.A. Memon, A.B. Ghanghro, M.F. Qureshi, M.A. Mughal, T. Qureshi, Hemoglobin adducts in paint industry workers: An electrophoretic analysis, Int. J. Adv. Life. Sci., 4 (2014) 208-215. hypersensitivity,and direct toxicity: the acid anhydrides, Brit. J. Ind. Med., 46 (1989) 222-32.
  • H. Keskinen, Cyclic acid anhydrides, The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards, 15 (2004) 1-74.
  • A.B. Ghanghro, S. Qureshi, S.A. Memon, F. Qureshi, Total serum immunoglobulin’s E levels in chemical industry workers (SITE area, Kotri, Jamshoro) exposed with organic acid anhydrides (OAAs), Brit. J. of Resear., 1 (2014) 120-23.
  • J. Jarvis, M.J. Seed, R. Elton, L. Swayer, R. Agius, Relationship between chemical structure and the occupational asthma hazard of Low molecular weight organic compounds, Occup. Envir. Med., 62 (2005) 243-250. Pathophysiology of anemia and erythrocytosis, Crit. Rev. Oncol. Hematol., 64 (2007) 139-158.
  • T.G. Janz, R.L. Johnson, S.D. Rubenstein, Anemia in the emergency department: evaluation and treatment. Emer. Med. Prac., 15 (2013) 1-15. Immunoglobulin E antibodies enhance pulmonary inflammation induced by inhalation of a chemical haptene, Clin. Exp. Allergy., 39 (2009) 417-425.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Research Article
Yazarlar

Sumera Qureshi Bu kişi benim

Allah Bux Ghanghro Bu kişi benim

Muhammad Faisal Qureshi Bu kişi benim

Tahira Qureshi Bu kişi benim

Shaista Khan Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 45 Sayı: 2

Kaynak Göster

APA Qureshi, S., Ghanghro, A. B., Qureshi, M. F., Qureshi, T., vd. (2017). Hemoglobin Durumunun Vaka Çalışması: S.I.T.E. Bölgesi, Kotri, Sindh, Pakistan’da Boyama ve Kimyasal Endüstrisinin Çalışanlarının Organik Asit Anhidritlere Maruz Kalması. Hacettepe Journal of Biology and Chemistry, 45(2), 245-249.
AMA Qureshi S, Ghanghro AB, Qureshi MF, Qureshi T, Khan S. Hemoglobin Durumunun Vaka Çalışması: S.I.T.E. Bölgesi, Kotri, Sindh, Pakistan’da Boyama ve Kimyasal Endüstrisinin Çalışanlarının Organik Asit Anhidritlere Maruz Kalması. HJBC. Haziran 2017;45(2):245-249.
Chicago Qureshi, Sumera, Allah Bux Ghanghro, Muhammad Faisal Qureshi, Tahira Qureshi, ve Shaista Khan. “Hemoglobin Durumunun Vaka Çalışması: S.I.T.E. Bölgesi, Kotri, Sindh, Pakistan’da Boyama Ve Kimyasal Endüstrisinin Çalışanlarının Organik Asit Anhidritlere Maruz Kalması”. Hacettepe Journal of Biology and Chemistry 45, sy. 2 (Haziran 2017): 245-49.
EndNote Qureshi S, Ghanghro AB, Qureshi MF, Qureshi T, Khan S (01 Haziran 2017) Hemoglobin Durumunun Vaka Çalışması: S.I.T.E. Bölgesi, Kotri, Sindh, Pakistan’da Boyama ve Kimyasal Endüstrisinin Çalışanlarının Organik Asit Anhidritlere Maruz Kalması. Hacettepe Journal of Biology and Chemistry 45 2 245–249.
IEEE S. Qureshi, A. B. Ghanghro, M. F. Qureshi, T. Qureshi, ve S. Khan, “Hemoglobin Durumunun Vaka Çalışması: S.I.T.E. Bölgesi, Kotri, Sindh, Pakistan’da Boyama ve Kimyasal Endüstrisinin Çalışanlarının Organik Asit Anhidritlere Maruz Kalması”, HJBC, c. 45, sy. 2, ss. 245–249, 2017.
ISNAD Qureshi, Sumera vd. “Hemoglobin Durumunun Vaka Çalışması: S.I.T.E. Bölgesi, Kotri, Sindh, Pakistan’da Boyama Ve Kimyasal Endüstrisinin Çalışanlarının Organik Asit Anhidritlere Maruz Kalması”. Hacettepe Journal of Biology and Chemistry 45/2 (Haziran 2017), 245-249.
JAMA Qureshi S, Ghanghro AB, Qureshi MF, Qureshi T, Khan S. Hemoglobin Durumunun Vaka Çalışması: S.I.T.E. Bölgesi, Kotri, Sindh, Pakistan’da Boyama ve Kimyasal Endüstrisinin Çalışanlarının Organik Asit Anhidritlere Maruz Kalması. HJBC. 2017;45:245–249.
MLA Qureshi, Sumera vd. “Hemoglobin Durumunun Vaka Çalışması: S.I.T.E. Bölgesi, Kotri, Sindh, Pakistan’da Boyama Ve Kimyasal Endüstrisinin Çalışanlarının Organik Asit Anhidritlere Maruz Kalması”. Hacettepe Journal of Biology and Chemistry, c. 45, sy. 2, 2017, ss. 245-9.
Vancouver Qureshi S, Ghanghro AB, Qureshi MF, Qureshi T, Khan S. Hemoglobin Durumunun Vaka Çalışması: S.I.T.E. Bölgesi, Kotri, Sindh, Pakistan’da Boyama ve Kimyasal Endüstrisinin Çalışanlarının Organik Asit Anhidritlere Maruz Kalması. HJBC. 2017;45(2):245-9.

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