A Novel, Simple and Green Capillary Electrophoresis Determınation of Sertraline in Pharmaceutical Dosage Forms

Year 2017, Volume: 45 Issue: 4, 509 - 514, 01.11.2017

Senem Şanlı Elvan Özsoy Nurullah Şanlı

Abstract

Asimple, accurate, precise and economical capillary electrophoresis method has been developed for estimation of Sertraline in pharmaceutical dosage form. The estimation of Sertraline was done at 205 nm in pH 4.0 phosphate buffer. In the developed method, linearity over the concentration range of 1-12 μg.mL-1 of Sertraline was observed. The linear regression was found to be 0.999. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method. The precision intra-day & inter-day of method was found within limits RSD < 2% . The sensitivity of the method was assessed by determining limit of detection and limit of quantification. It could be concluded from the results obtained in the present investigation that the method for estimation of Sertraline in pharmaceutical dosage form is simple, rapid, accurate, precise, green and economical, also it could be used, successfully, in the quality control of pharmaceutical formulations and other routine laboratory analysis.

Keywords

Psychiatric illnesses, depression, sertraline, Capillary electrophoresis

Sertralin’in Farmasötik Dozaj Formlarında Yeni, Basit, Çevreci Kapiler Elektroforez ile Tayini

Abstract

S ertralinin ilaç formülasyonlarından tayini için kolay, seçici, kesin ve ekonomik kapiler elektroforez yöntemi geliştirilmiştir. Tayin 205 nm’de pH’sı 4.0 olan fosfat tamponunda gerçekleştirilmiştir. Geliştirilen yöntemde, doğrusal aralık 1-12 µg.mL-1 arasında bulunmuştur. Korelasyon katsayısı 0.999’dur. Analiz sonuçları istatistiksel olarak valide edilmiş ve geri kazanım çalışmaları yöntemin doğruluğunu onaylamıştır. Yöntemin kesinliği gün içi ve günler arası belirlenen sınırlar içerisinde bulunmuştur RSD < 2% . Yöntemin duyarlılığı, tayin sınırları belirlenerek değerlendirilmiştir. Bu çalışmada, sertralinin farmasötik dozaj formlarında tayini için basit, hızlı, doğru, hassas, yeşil, ekonomik ve diğer rutin laboratuvar çalışmalarında kullanabilecek bir yöntem geliştirildiği sonucuna varılmıştır

Keywords

Psikiyatrik hastalıklar, depresyon, sertralin, kapiler elektroforez

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