Glaucium Cappadocicum: Screening on Antioxidant, Antimicrobial, Anticholinesterase Inhibition in vitro

Year 2024, Volume: 52 Issue: 1, 1 - 9, 04.01.2024

Sevgi Altın , Ekrem Köksal

https://doi.org/10.15671/hjbc.1332418

Abstract

Glaucium cappadocicum is an endemic plant in Turkey, but there have been no research on it. In this work, the total phenolic and flavonoid content of extracts made from this plant were measured. Additionally, their antioxidant, antibacterial, and anticholinesterase activities were assessed. The extracts' antioxidant properties were assessed using the DPPH and FRAP methods, their antibacterial effects were assessed using the disk diffusion method on Gram-positive and Gram-negative bacteria, and their ability to inhibit cholinesterase activity was assessed using the Ellman method. In all biological activity assays, the alkaloid extract had the maximum activity. Alkaloid extract shown higher inhibition than the common inhibitor Tacrine in investigations on enzyme inhibition, in particular. All of these investigations demonstrate the potent anticholinesterase and antibacterial properties of Glaucium cappadocicum as well as its value as a good source of antioxidant system defense.

Keywords

Glaucium cappadocicum, enzyme inhibition, antimicrobial, antioxidant

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