Evaluatıon of kallistatin and some biochemical parameters in rats with experimental Liver Injury

Yıl 2021, , 136 - 143, 30.12.2021

Ehsan Sepehrizadeh1 Süleyman Kozat , Ömer Faruk Keleş , Erhan Ayna

https://doi.org/10.30704/http-www-jivs-net.938831

Cited By: 1

Öz

This study aims to determine the possible relationship between the levels of Kallistatin and the severity of liver injury in rats that were exposed to carbon tetrachloride (CCl4). According to the results, serum ALT, AST, LDH, GGT and Collagen-I and Collagen-III levels in rats in the severe group were higher than control. Histopathological examination of rats in injury groups showed severe morphological changes that were resulted in cell dissociation and disruption of the liver lobe architecture in the liver parenchyma of rats that received CCl4. Kallistatin serum level decreasing respectively in M1, M2, and S groups compared to the control group, and the lowest amount was belonging to the severe group. As a result, there was a reverse connection between Kallistatin serum level and the liver injury intensity. Serum kallistatin levels are an essential parameter in determining liver tissue damage levels, and measuring it may help provide a treatment prognosis.

Anahtar Kelimeler

Kallistatin, Liver injury, CCl4, Blood parameter

Kaynakça

• Abdelghany AH, BaSalamah MA, Idris S, Ahmad J, & Refaat B. (2016). The fibrolytic potentials of vitamin D and thymoquinone remedial therapies: insights from liver fibrosis established by CCl4 in rats. J Transl Med. 29(14): 281.
• Ala-Kokko L, Pihlajaniemi T, Myers JC, Kivirikko KI, & Savolainen ER. (1987). Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat. Biochem. 244:75-9.
• Althnaian T, Albokhadaim I, & El-Bahr SM. (2013). Biochemical and histopathological study in rats intoxicated with carbontetrachloride and treated with camel milk. SpringerPlus. 2: 1-7.
• Asmaa SM, Al-Diwan MA, & AL-Jadaan SA. (2018). Hematologıcal Profıle Of Rats Treated Wıth Quercetın Derıvatıve Agaınst Carbon Tetrachlorıde (CCl4) Toxıcıty. Bas J Vet 17: 1-15. Chao J, Bledsoe G, & Chao L. (2016). Protective role of kallistatin in vascular and organ injury. Hypertension. 68: 533-41.
• Chao J, Li P, & Chao L. (2017). Kallistatin suppresses cancer development by multi-factorial actions. Crit Rev Oncol. 113: 71-8.
• Cheng, Z., Lv, Y., Pang, S., Bai, R., Wang, M., Lin, S., & Xu, R. (2015). Kallistatin, a new and reliable biomarker for the diagnosis of liver cirrhosis. Acta Pharmaceutica Sinica B, 5(3), 194-200.
• Chung, G. E., Yim, J. Y., Kim, D., Kwak, M. S., Yang, J. I., Chung, S. J., & Kim, J. S. (2016). Associations between white blood cell count and the development of incidental nonalcoholic fatty liver disease. Gastroenterology Research and Practice, 2016:1-7.
• Eidi, A., Mortazavi, P., Moghadam, J. Z., & Mardani, P. M. (2015). Hepatoprotective effects of Portulaca oleracea extract against CCl4-induced damage in rats. Pharmaceutical Biology, 53(7), 1042-1051. Gitlin, N., & Serio, K. M. (1992). Ischemic hepatitis: widening horizons. American Journal of Gastroenterology (Springer Nature), 87(7): 831-836.
• Okojie, S., Idu, M., & Ovuakporie-Uvo, O. (2017). Protective effects of neem (Azadirachta indica A. Juss) seed oil on carbon tetrachloride-induced hepatotoxicity in Wistar rats. Journal of Medicinal Plants for Economic Development, 1(1), 1-5.
• Jie, Y., Gong, J., Xiao, C., Zhu, S., Zhou, W., Luo, J., ... & Hu, B. (2018). Low platelet to white blood cell ratio indicates poor prognosis for acute-on-chronic liver failure. BioMed Research International, 2018; 1-5.
• Kocabayoglu, P., & Friedman, S. L. (2013). Cellular basis of hepatic fibrosis and its role in inflammation and cancer. Front Biosci (Schol Ed), 5(3), 217-230.. Li, P., Guo, Y., Bledsoe, G., Yang, Z. R., Fan, H., Chao, L., & Chao, J. (2015). Kallistatin treatment attenuates lethality and organ injury in mouse models of established sepsis. Critical Care, 19(1), 1-12..
• Li, Z., Wei, W., Chen, B., Cai, G., Li, X., Wang, P., .& Dong, W. (2016). The effect of rhCygb on CCl 4-induced hepatic fibrogenesis in rat. Scientific Reports, 6(1), 1-11.
• Mandal, A., Karmakar, R., Bandyopadhyay, S., & Chatterjee, M. (1998). Antihepatotoxic potential of Trianthema portulacastrum in carbon tetrachloride-induced chronic hepatocellular injury in mice: reflection in haematological, histological and biochemical characteristics. Archives of Pharmacal Research, 21(3), 223-230.
• Kruepunga, N., Hakvoort, T. B., Hikspoors, J. P., Köhler, S. E., & Lamers, W. H. (2019). Anatomy of rodent and human livers: What are the differences?. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1865(5), 869-878. McGill, M. R. (2016). The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI Journal, 15, 817.
• Moreira, A. J., Rodrigues, G. R., Bona, S., Fratta, L. X. S., Weber, G. R., Picada, J. N., & Marroni, N. P. (2017). Ductular reaction, cytokeratin 7 positivity, and gamma-glutamyl transferase in multistage hepatocarcinogenesis in rats. Protoplasma, 254(2), 911-920.
• Raafat, N., Aal, S. M. A., Abdo, F. K., & El Ghonaimy, N. M. (2015). Mesenchymal stem cells: in vivo therapeutic application ameliorates carbon tetrachloride induced liver fibrosis in rats. The international Journal of Biochemistry & Cell Biology, 68, 109-118.
• Rahmouni, F., Hamdaoui, L., Badraoui, R., & Rebai, T. (2017). Protective effects of Teucrium polium aqueous extract and ascorbic acid on hematological and some biochemical parameters against carbon tetrachloride (CCl4) induced toxicity in rats. Biomedicine & Pharmacotherapy, 91, 43-48.
• Recknagel, R. O., Glende Jr, E. A., Dolak, J. A., & Waller, R. L. (1989). Mechanisms of carbon tetrachloride toxicity. Pharmacology & therapeutics, 43(1), 139-154.. Rojkind M & Perez-Tamayo R. (1983). Liver fibrosis. Int Rev Connect Tissue Res. 10: 333-93.
• Nwidu LL, Oboma YI, Elmorsy E, & Carter WG. Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae). JBCPP. 2018; 29: 609-19.
• Thanh TB, Thanh HN, Minh HP, Le-Thi-Thu H, Ly HD, & Duc LV. (2015). Protective effect of Tetracera scandens L. leaf extract against CCl4-induced acute liver injury in rats. Asian Pac J Trop Biomed. 5: 221-7.
• Vdoviaková K, Petrovová E, & Maloveská M. (2016). Surgical anatomy of the gastrointestinal tract and its vasculature in the laboratory rat. Gastroenterol Res Pract. 2016:2-7. Wang G, Zou J, Yu X, Yin S, & Tang C. (2020).The antiatherogenic function of kallistatin and its potential mechanism. Acta Biochim Biophys Sin. 52: 583-9.
• Yanguas, S. C., Cogliati, B., Willebrords, J., Maes, M., Colle, I., van den Bossche, B., & Vinken, M. (2016). Experimental models of liver fibrosis. Archives of toxicology, 90(5), 1025-1048.