Araştırma Makalesi
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Yıl 2018, Cilt 2, Sayı 3, 66 - 71, 31.12.2018
https://doi.org/10.30704/http-www-jivs-net.453151

Öz

Kaynakça

  • Appleton, G. O., Li, Y., Taffet, G. E., Hartley, C. J., Michael, L. H., Entman, M. L., Roberts, R. & Khoury, D. S. (2004). Determinants of cardiac electrophysiological properties in mice. Journal of Interventional Cardiac Electrophysiology, 11(1), 5-14.
  • Berul, C. I., Christe, M. E., Aronovitz, M. J., Maguire, C. T., Seidman, C. E., Seidman, J. G. & Mendelsohn, M. E. (1998). Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities. Journal of Interventional Cardiac Electrophysiology, 2(1), 7-14.
  • Brouillette, J., Rivard, K., Lizotte, E. & Fiset, C. (2005). Sex and strain differences in adult mouse cardiac repolarization: importance of androgens. Cardiovascular Rearch, 65(1), 148-157.
  • Brouillette, J., Trepanier-Boulay, V. & Fiset, C. (2003). Effect of androgen deficiency on mouse ventricular repolarization. The Journal of Physiology, 546(Pt 2), 403-413.
  • Cheng, J. (2006). Evidences of the gender-related differences in cardiac repolarization and the underlying mechanisms in different animal species and human. Fundamentals & Clinical Pharmacology, 20(1), 1-8.
  • Danik, S., Cabo, C., Chiello, C., Kang, S., Wit, A. L. & Coromilas, J. (2002). Correlation of repolarization of ventricular monophasic action potential with ECG in the murine heart. American Journal of Physiolology: Heart and Circulatory Physiology, 283(1), H372-381.
  • Dhala, A., Underwood, D., Leman, R., Madu, E., Baugh, D., Ozawa, Y., Kasamaki, Y., Xue, Q., Reddy, S. & Multicenter, P.-R. S. (2002). Signal-averaged P-wave analysis of normal controls and patients with paroxysmal atrial fibrillation: a study in gender differences, age dependence, and reproducibility. Clinical Cardiology, 25(11), 525-531.
  • Erhardt, W., Hebestedt, A., Aschenbrenner, G., Pichotka, B. & Blumel, G. (1984). A Comparative-Study with Various Anesthetics in Mice (Pentobarbital, Ketamine-Xylazine, Carfentanyl-Etomidate). Research in Experimental Medicine, 184(3), 159-169.
  • Flecknell, P. (2009). Laboratory Animal Anaesthesia. San Francisco, USA, Elsevier Science.
  • Gargiulo, S., Greco, A., Gramanzini, M., Esposito, S., Affuso, A., Brunetti, A. & Vesce, G. (2012). Mice anesthesia, analgesia, and care, Part I: anesthetic considerations in preclinical research. ILAR J / National Research Council, Institute of Laboratory Animal Resources, 53(1), E55-69.
  • Gargiulo, S., Greco, A., Gramanzini, M., Esposito, S., Affuso, A., Brunetti, A. & Vesce, G. (2012). Mice anesthesia, analgesia, and care, Part II: anesthetic considerations in preclinical imaging studies. ILAR J National Research Council, Institute of Laboratory Animal Resources, 53(1), E70-81.
  • Hara, Y., Chugun, A., Nakaya, H. & Kondo, H. (1998). Tonic block of the sodium and calcium currents by ketamine in isolated guinea pig ventricular myocytes. The Journal of Veerinary Medical Science, 60(4), 479-483.
  • James, A. F., Choisy, S. C. & Hancox, J. C. (2007). Recent advances in understanding sex differences in cardiac repolarization. Progress in Biophysics and Biophysical Chemistry, 94(3), 265-319.
  • Jeron, A., Mitchell, G. F., Zhou, J., Murata, M., London, B., Buckett, P., Wiviott, S. D. & Koren, G. (2000). Inducible polymorphic ventricular tachyarrhythmias in a transgenic mouse model with a long Q-T phenotype. American Journal of Physiolology: Heart and Circulatory Physiology, 278(6), H1891-1898.
  • Lairez, O., Lonjaret, L., Ruiz, S., Marchal, P., Franchitto, N., Calise, D., Fourcade, O., Mialet-Perez, J., Parini, A. & Minville, V. (2013). Anesthetic regimen for cardiac function evaluation by echocardiography in mice: comparison between ketamine, etomidate and isoflurane versus conscious state. Laboratory Animal, 47(4), 284-290.
  • Liu, G., Iden, J. B., Kovithavongs, K., Gulamhusein, R., Duff, H. J. & Kavanagh, K. M. (2004). In vivo temporal and spatial distribution of depolarization and repolarization and the illusive murine T wave. The Journal of Physiology, 555(Pt 1), 267-279.
  • McGuill, M. V. & Rowan, A. N. (1989). Biological Effects of Blood Loss: Implications for Sampling Volumes and Techniques. ILAR J National Research Council, Institute of Laboratory Animal Resources,31(4), 5-20.
  • Mitchell, G. F., Jeron, A. & Koren, G. (1998). Measurement of heart rate and Q-T interval in the conscious mouse. The American Journal of Physiology, 274(3 Pt 2), H747-751.
  • Moss, A. J. (2010). Gender Differences in ECG Parameters and Their Clinical Implications. Annals of Noninvasive Electrocardiology, 15(1), 1-2.
  • Raabe, B. M., Artwohl, J. E., Purcell, J. E., Lovaglio, J. & Fortman, J. D. (2011). Effects of weekly blood collection in C57BL/6 mice. Journal of the American Association for Laboratory Animal Science, 50(5), 680-685.
  • Roth, D. M., Swaney, J. S., Dalton, N. D., Gilpin, E. A. & Ross, J., Jr. (2002). Impact of anesthesia on cardiac function during echocardiography in mice. American Journal of Physiolology: Heart and Circulatory Physiology, 282(6), H2134-2140.
  • Rusy, B. F., Amuzu, J. K., Bosscher, H. A., Redon, D. & Komai, H. (1990). Negative inotropic effect of ketamine in rabbit ventricular muscle. Anesthesia and Analgesia, 71(3), 275-278.
  • Ryan, K. L., Rickards, C. A., Hinojosa-Laborde, C., Cooke, W. H. & Convertino, V. A. (2012). Sympathetic responses to central hypovolemia: new insights from microneurographic recordings. Frontiers in Physiology, 3, 110.
  • Sachin Khane, R. & Surdi, A. D. (2012). Gender differences in the prevalence of electrocardiogram abnormalities in the elderly: a population survey in India. Iranian Journal of Medical Sciences, 37(2), 92-99.
  • Schadt, J. C. & Ludbrook, J. (1991). Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals. American Journal of Physiology, 260(2 Pt 2), H305-318.
  • Skoog, P., Mansson, J. & Thoren, P. (1985). Changes in renal sympathetic outflow during hypotensive haemorrhage in rats. Acta Physiologica Scandinavica, 125(4), 655-660.
  • Speerschneider, T. & Thomsen, M. B. (2013). Physiology and analysis of the electrocardiographic T wave in mice. Acta Physiologica (Oxford), 209(4), 262-271.
  • Stypmann, J. (2007). Doppler ultrasound in mice. Echocardiography, 24(1), 97-112.
  • Tan, T. P., Gao, X. M., Krawczyszyn, M., Feng, X., Kiriazis, H., Dart, A. M. & Du, X. J. (2003). Assessment of cardiac function by echocardiography in conscious and anesthetized mice: importance of the autonomic nervous system and disease state. Journal of Cardiovascular Pharmacology, 42(2), 182-190.
  • Xu, Q., Ming, Z., Dart, A. M. & Du, X. J. (2007). Optimizing dosage of ketamine and xylazine in murine echocardiography. Clinical and Experimental Pharmacology & Physiology, 34(5-6), 499-507.
  • Yan, G. X., Shimizu, W. & Antzelevitch, C. (1998). Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations. Circulation, 98(18), 1921-1927.

The Effects of Acute Blood Loss on Electrocardiogram in Male and Female Swiss Albino Mice

Yıl 2018, Cilt 2, Sayı 3, 66 - 71, 31.12.2018
https://doi.org/10.30704/http-www-jivs-net.453151

Öz

The aim of the present study is to investigate the possible effects of acute blood loss (1% of body weight) on electrocardiogram (ECG) in male and female Swiss albino mice. Anesthesia was maintained with the ketamine-xylazine combination. The tail was cut using a scalpel blade and blood at a ratio of 1% body weight was collected in capillary tubes. ECG recording was done by using the standard lead II. P and T waves, intervals of PQ, QT, and RR, and QRS complex were measured after all ECG was recorded. The amplitude of P and QRS waves were significantly higher in males than that of females (P<0.005, P<0.05 respectively). PR intervals were also longer in male mice than those of females (P<0,001). Neither blood removal nor anesthesia affected the amplitude of the QRS complex in any gender. The duration of the QRS complex was longer in males than females in both groups (P<0,01). Blood removal led to a reduction in the duration of the QRS complex in male mice (P<0.01). Anesthesia caused the prolongation of the QT and QTc in all groups (P<0,001, P<0,05 respectively). Females had longer QT interval compared to male groups (P<0,05) and blood removal caused prolongation of the QT period in females (P<0,05). An acute blood loss of 1% of body weight in male mice led to a reduction in heart rate, whereas prolongation of the QT interval in female mice. It was concluded that gender is an important factor in terms of blood-loss associated ECG alterations.

Kaynakça

  • Appleton, G. O., Li, Y., Taffet, G. E., Hartley, C. J., Michael, L. H., Entman, M. L., Roberts, R. & Khoury, D. S. (2004). Determinants of cardiac electrophysiological properties in mice. Journal of Interventional Cardiac Electrophysiology, 11(1), 5-14.
  • Berul, C. I., Christe, M. E., Aronovitz, M. J., Maguire, C. T., Seidman, C. E., Seidman, J. G. & Mendelsohn, M. E. (1998). Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities. Journal of Interventional Cardiac Electrophysiology, 2(1), 7-14.
  • Brouillette, J., Rivard, K., Lizotte, E. & Fiset, C. (2005). Sex and strain differences in adult mouse cardiac repolarization: importance of androgens. Cardiovascular Rearch, 65(1), 148-157.
  • Brouillette, J., Trepanier-Boulay, V. & Fiset, C. (2003). Effect of androgen deficiency on mouse ventricular repolarization. The Journal of Physiology, 546(Pt 2), 403-413.
  • Cheng, J. (2006). Evidences of the gender-related differences in cardiac repolarization and the underlying mechanisms in different animal species and human. Fundamentals & Clinical Pharmacology, 20(1), 1-8.
  • Danik, S., Cabo, C., Chiello, C., Kang, S., Wit, A. L. & Coromilas, J. (2002). Correlation of repolarization of ventricular monophasic action potential with ECG in the murine heart. American Journal of Physiolology: Heart and Circulatory Physiology, 283(1), H372-381.
  • Dhala, A., Underwood, D., Leman, R., Madu, E., Baugh, D., Ozawa, Y., Kasamaki, Y., Xue, Q., Reddy, S. & Multicenter, P.-R. S. (2002). Signal-averaged P-wave analysis of normal controls and patients with paroxysmal atrial fibrillation: a study in gender differences, age dependence, and reproducibility. Clinical Cardiology, 25(11), 525-531.
  • Erhardt, W., Hebestedt, A., Aschenbrenner, G., Pichotka, B. & Blumel, G. (1984). A Comparative-Study with Various Anesthetics in Mice (Pentobarbital, Ketamine-Xylazine, Carfentanyl-Etomidate). Research in Experimental Medicine, 184(3), 159-169.
  • Flecknell, P. (2009). Laboratory Animal Anaesthesia. San Francisco, USA, Elsevier Science.
  • Gargiulo, S., Greco, A., Gramanzini, M., Esposito, S., Affuso, A., Brunetti, A. & Vesce, G. (2012). Mice anesthesia, analgesia, and care, Part I: anesthetic considerations in preclinical research. ILAR J / National Research Council, Institute of Laboratory Animal Resources, 53(1), E55-69.
  • Gargiulo, S., Greco, A., Gramanzini, M., Esposito, S., Affuso, A., Brunetti, A. & Vesce, G. (2012). Mice anesthesia, analgesia, and care, Part II: anesthetic considerations in preclinical imaging studies. ILAR J National Research Council, Institute of Laboratory Animal Resources, 53(1), E70-81.
  • Hara, Y., Chugun, A., Nakaya, H. & Kondo, H. (1998). Tonic block of the sodium and calcium currents by ketamine in isolated guinea pig ventricular myocytes. The Journal of Veerinary Medical Science, 60(4), 479-483.
  • James, A. F., Choisy, S. C. & Hancox, J. C. (2007). Recent advances in understanding sex differences in cardiac repolarization. Progress in Biophysics and Biophysical Chemistry, 94(3), 265-319.
  • Jeron, A., Mitchell, G. F., Zhou, J., Murata, M., London, B., Buckett, P., Wiviott, S. D. & Koren, G. (2000). Inducible polymorphic ventricular tachyarrhythmias in a transgenic mouse model with a long Q-T phenotype. American Journal of Physiolology: Heart and Circulatory Physiology, 278(6), H1891-1898.
  • Lairez, O., Lonjaret, L., Ruiz, S., Marchal, P., Franchitto, N., Calise, D., Fourcade, O., Mialet-Perez, J., Parini, A. & Minville, V. (2013). Anesthetic regimen for cardiac function evaluation by echocardiography in mice: comparison between ketamine, etomidate and isoflurane versus conscious state. Laboratory Animal, 47(4), 284-290.
  • Liu, G., Iden, J. B., Kovithavongs, K., Gulamhusein, R., Duff, H. J. & Kavanagh, K. M. (2004). In vivo temporal and spatial distribution of depolarization and repolarization and the illusive murine T wave. The Journal of Physiology, 555(Pt 1), 267-279.
  • McGuill, M. V. & Rowan, A. N. (1989). Biological Effects of Blood Loss: Implications for Sampling Volumes and Techniques. ILAR J National Research Council, Institute of Laboratory Animal Resources,31(4), 5-20.
  • Mitchell, G. F., Jeron, A. & Koren, G. (1998). Measurement of heart rate and Q-T interval in the conscious mouse. The American Journal of Physiology, 274(3 Pt 2), H747-751.
  • Moss, A. J. (2010). Gender Differences in ECG Parameters and Their Clinical Implications. Annals of Noninvasive Electrocardiology, 15(1), 1-2.
  • Raabe, B. M., Artwohl, J. E., Purcell, J. E., Lovaglio, J. & Fortman, J. D. (2011). Effects of weekly blood collection in C57BL/6 mice. Journal of the American Association for Laboratory Animal Science, 50(5), 680-685.
  • Roth, D. M., Swaney, J. S., Dalton, N. D., Gilpin, E. A. & Ross, J., Jr. (2002). Impact of anesthesia on cardiac function during echocardiography in mice. American Journal of Physiolology: Heart and Circulatory Physiology, 282(6), H2134-2140.
  • Rusy, B. F., Amuzu, J. K., Bosscher, H. A., Redon, D. & Komai, H. (1990). Negative inotropic effect of ketamine in rabbit ventricular muscle. Anesthesia and Analgesia, 71(3), 275-278.
  • Ryan, K. L., Rickards, C. A., Hinojosa-Laborde, C., Cooke, W. H. & Convertino, V. A. (2012). Sympathetic responses to central hypovolemia: new insights from microneurographic recordings. Frontiers in Physiology, 3, 110.
  • Sachin Khane, R. & Surdi, A. D. (2012). Gender differences in the prevalence of electrocardiogram abnormalities in the elderly: a population survey in India. Iranian Journal of Medical Sciences, 37(2), 92-99.
  • Schadt, J. C. & Ludbrook, J. (1991). Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals. American Journal of Physiology, 260(2 Pt 2), H305-318.
  • Skoog, P., Mansson, J. & Thoren, P. (1985). Changes in renal sympathetic outflow during hypotensive haemorrhage in rats. Acta Physiologica Scandinavica, 125(4), 655-660.
  • Speerschneider, T. & Thomsen, M. B. (2013). Physiology and analysis of the electrocardiographic T wave in mice. Acta Physiologica (Oxford), 209(4), 262-271.
  • Stypmann, J. (2007). Doppler ultrasound in mice. Echocardiography, 24(1), 97-112.
  • Tan, T. P., Gao, X. M., Krawczyszyn, M., Feng, X., Kiriazis, H., Dart, A. M. & Du, X. J. (2003). Assessment of cardiac function by echocardiography in conscious and anesthetized mice: importance of the autonomic nervous system and disease state. Journal of Cardiovascular Pharmacology, 42(2), 182-190.
  • Xu, Q., Ming, Z., Dart, A. M. & Du, X. J. (2007). Optimizing dosage of ketamine and xylazine in murine echocardiography. Clinical and Experimental Pharmacology & Physiology, 34(5-6), 499-507.
  • Yan, G. X., Shimizu, W. & Antzelevitch, C. (1998). Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations. Circulation, 98(18), 1921-1927.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Hekimlik
Bölüm Araştırma Makaleleri
Yazarlar

Cengiz ÜNSAL> (Sorumlu Yazar)
Adnan Menderes Üniversitesi Veteriner Fakültesi
Türkiye


Fazilet ÖZDEN Bu kişi benim


Hümeyra ÜNSAL>
Adnan Menderes Üniversitesi Veteriner Fakültesi
Türkiye


Muharrem BALKAYA>
Adnan Menderes Üniversitesi Veteriner Fakültesi
Türkiye

Yayımlanma Tarihi 31 Aralık 2018
Yayınlandığı Sayı Yıl 2018, Cilt 2, Sayı 3

Kaynak Göster

APA Ünsal, C. , Özden, F. , Ünsal, H. & Balkaya, M. (2018). The Effects of Acute Blood Loss on Electrocardiogram in Male and Female Swiss Albino Mice . Journal of Istanbul Veterinary Sciences , 2 (3) , 66-71 . DOI: 10.30704/http-www-jivs-net.453151

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