Chemotheraphy and chemosensitivity test in canine mammary tumors

Yıl 2020, Vetexpo-2019, KHVD-2019, 2 - 2, 31.03.2020

Özge Turna

Öz

Canine mammary tumors are treated mainly by operation, radiotherapy, chemotherapy and
immunotherapy. Malignant tumor cells tend to metastasize to regional lymph nodes and / or distant tissues
by lymphatics. In many cases, micrometastases have already been formed by the time of mastectomy, and
in this case the operation alone will not interfere with the progression of the disease. It has been reported
that operative administration will be easier with preoperative chemotherapy. Postoperative chemotherapy
is a powerful adjunctive treatment that can improve disease-free survival and quality of life by controlling
distant spread of the disease. There are many chemotherapeutics applied as adjuvant treatment in canine
mammary tumors. It is possible to benefit from chemotherapy in dogs with mammary tumors by
evaluating the general condition of the dog, correct histopathological diagnosis, selection of appropriate
chemotherapeutic drug and appropriate dosing. However, different results were obtained regarding tumor
regression and disease-free survival in different patients with the same histopathology tumor after the
same chemotherapy protocols. One of the reasons why today's success in cancer treatment is not
increasing very well despite the introduction of many new cancer drugs is the possibility of this different
response. This demonstrates the necessity of individual treatment in cancer patients. Each cancer patient is
different from one another at the molecular level. It is possible to determine the response of the patient's
tissue to chemotherapy by using ATP-tumor chemosensitivity test in laboratory. Quantitative testing of the
cytotoxic potential of chemotherapeutic agents applied to cells obtained from canine mammary tumor
tissues will be able to develop individualized treatment methods. In this presentation, the
chemotherapeutic agents used so far in canine mammary tumors, the use of chemosensitivity test in canine
mammary tumors and the points to be considered in chemotherapy applications are mentioned.

Anahtar Kelimeler

Canine, mammary tumor, micrometastase, chemosensitivity tests, micrometastases

Kaynakça

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