Araştırma Makalesi
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Changes in phosphorus and some biochemical parameters in cats with open and closed cervix pyometra

Yıl 2023, Cilt: 7 Sayı: 1, 21 - 26, 30.04.2023

Öz

Pyometra is a disease defined as a purulent inflammation of the uterus and may have multisystemic effects. In this study, investigation of the changes in leukocytes, calcium, phosphorus and some biochemical parameters in cats with open and closed cervix pyometra was aimed. A total number of 48 queens were enrolled in the study. Twenty three healthy diestrus queens were in Group H that presented to the clinic for ovariohysterectomy. Twenty five queens constituted the pyometra group (Group PYO) which were divided into 2 groups with regard to the presence of vaginal discharge which consist of open cervix pyometra (Group OP; n=15) and closed cervix pyometra (Group CP; n=10). The mean WBC level was significantly higher in group PYO than in group H (P<0.001). The highest WBC level was detected in group CP. Serum ALT and TP levels in group CP were higher than in group OP and Group H; respectively (P<0.01 and P<0.05). The highest ALB and ALB/GLOB levels were determined in group H; respectively (P<0.05 and P<0.01). Serum GLOB levels in group CP and group OP were significantly higher than in group H (P<0.01). A significant rise in ALKP levels in group PYO were detected (P<0.01). The highest PHOS levels were identified in group CP (P<0.01). To best of our knowledge, this is the first report which is detected hyperphosphatemia in closed cervix pyometra in queens. In conclusion, pyometra is a serious disease that needs to be well evaluated with laboratory tests in order to reveal its multi-systemic effects.

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Kaynakça

  • Agudelo, C. F. (2005). Cystic endometrial hyperplasia-pyometra complex in cats. A review. The veterinary quarterly, 27(4), 173–182.
  • Alacam, E. (1998). Karnivorlarda üreme süreci ve sorunları, In H.Y. Imren (Ed). Kedi ve Köpek Hastalıkları, pp437-512. Ankara, Türkiye: Medisan.
  • Althausen, T. L., & Thoenes, E. (1932). Influence on carbohydrate metabolism of experimentally induced hepatic changes: II. Phosphorus poisoning. Archives of Internal Medicine, 50(1), 58-75.
  • Asheim, A. (1964). Renal function in dogs with pyometra. 7. Calcium and potassium levels in dogs with pyometra and polyuria. Acta Veterinaria Scandinavica, 5, 115-122.
  • Borresen, B., & Skrede, S. (1980). Pyometra in the dog- a pathophysiological investigation V. The presence of intrahepatic cholestasis and an "acute phase reaction". Nordisk Veterinærmedicin,32(9), 378-386.
  • Chung, P. Y., Sitrin, M. D., & Te, H. S. (2003). Serum phosphorus levels predict clinical outcome in fulminant hepatic failure. Liver Transplantation, 9(3), 248-253.
  • Comazzi, S., Pieralisi, C., & Bertazzolo, W. (2004). Haematological and biochemical abnormalities in canine blood: frequency and associations in 1022 samples. Journal of Small Animal Practice, 45(7), 343–349.
  • Enginler, S. O., Ateş, A., Diren Sığırcı, B., Sontaş, B. H., Sönmez, K., Karaçam, E., Ekici, H., Evkuran Dal, G., & Gürel, A. (2014). Measurement of C-reactive protein and prostaglandin F2α metabolite concentrations in differentiation of canine pyometra and cystic endometrial hyperplasia/mucometra. Reproduction in Domestic Animals, 49(4), 641–647.
  • Fantoni, D.T., Auler Junior, J.O., Futema, F., Cortopassi, S.R., Migliati, E.R., Faustino, M., & De Oliveira, C.M. (1999). Intravenous administration of hypertonic sodium chloride solution with dextran or isotonic sodium chloride solution for treatment of septic shock secondary to pyometra in dogs. Journal of the American Veterinary Medical Association, 215(9), 1283-1287.
  • Günay Uçmak, Z., Küçükbekir, Ç.N.& Uçmak, M. (2019, April, 17-19). A case of pyometra in five month old queen. Paper presented at the 21st International Veterinary Medicine Student Scientific Research Congress. İstanbul, Turkey.
  • Hagman, R. (2012). Clinical and molecular characteristics of pyometra in female dogs. Reproduction in Domestic Animals, 47, 323-325.
  • Hagman, R., Holst, B. S., Möller, L., & Egenvall, A. (2014). Incidence of pyometra in Swedish insured cats. Theriogenology, 82(1), 114-120.
  • Hagman, R. (2022). Pyometra in Small Animals 2.0. Veterinary clinics of North America. Small Animal Practice, 52(3), 631–657.
  • Hollinshead, F., & Krekeler, N. (2016). Pyometra in the queen: To spay or not to spay? Journal of Feline Medicine and Surgery, 18(1), 21–33.
  • Johnson, C. A. (1994). Female reproduction and disorders of the female reproductive tract. The cat: Diseases and clinical management (Sherding RG, Ed.), Saunders, Philadelphia, 1855-1876.
  • Johnston, S. D., Root Kustritz, M. V., & Olson, P. S. (2001). Canine and feline theriogenology. Saunders.
  • Kenney, K. J., Matthiesen, D. T., Brown, N. O., & Bradley, R. L. (1987). Pyometra in cats: 183 cases (1979-1984). Journal of the American Veterinary Medical Association, 191(9), 1130–1132.
  • Keshavprasad, P. R., Ravikumar, K., Senthilkumar, K., Kathirvel, S., Gopikrishnan, D., Ganesan, A., & Ezakial Napolean, R. (2023). Effect of methylergometrine maleate and mifepristone on uterine biometry and haemato-biochemical changes in canine open cervix pyometra. The Pharma Innovation Journal, 12(1), 1681-1684.
  • King, J. N., Tasker, S., Gunn‐Moore, D. A., & Strehlau, G. (2007). Prognostic factors in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 21(5), 906-916.
  • Koo, O. J., Hong, S. G., Kang, J. T., Park, J. E., Kim, M. J., Jang, G., & Lee, B. C. (2011). Closed-Cervix Pyometra in Young Dogs: 2 Cases. Journal of Embryo Transfer, 26(4), 283-286.
  • Kutzler, M. A., Krekeler, N., & Hollinshead, F. (2012). Pyometra. Small Animal Soft Tissue Surgery, 623-634.
  • Nak, D. (1999). Kedi ve köpeklerde pyometranın fizyopatolojisi, tanısı ve prostaglandinlerle sağaltımı. Yüzüncü Yıl Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 5,79.
  • Nak, D., Misirlioglu, D., Nak, Y., & Keskin, A. (2005). Clinical laboratory findings, vaginal cytology and pathology in a controlled study of pyometra in cats. Australian Veterinary Practitioner, 35(1), 10-14.
  • Verstegen, J., Dhaliwal, G., & Verstegen-Onclin, K. (2008). Mucometra, cystic endometrial hyperplasia, and pyometra in the bitch: advances in treatment and assessment of future reproductive success. Theriogenology, 70(3), 364–374.
  • Vilhena, H., Figueiredo, M., Cerón, J. J., Pastor, J., Miranda, S., Craveiro, H., Pires, M. A., Tecles, F., Rubio, C. P., Dabrowski, R., Duarte, S., Silvestre-Ferreira, A. C., & Tvarijonaviciute, A. (2018). Acute phase proteins and antioxidant responses in queens with pyometra. Theriogenology, 115, 30–37.
  • Werner, L. L., Turnwald, G. H. (1999). Immunologic and plasma protein disorders. In: M.D. Willard, H. Tvedten, G.H. Turnwald (Eds). Small Animal Clinical Diagnosis by Laboratory Methods (pp. 248–264). St Louis, US: W.B. Saunders.
Yıl 2023, Cilt: 7 Sayı: 1, 21 - 26, 30.04.2023

Öz

Proje Numarası

-

Kaynakça

  • Agudelo, C. F. (2005). Cystic endometrial hyperplasia-pyometra complex in cats. A review. The veterinary quarterly, 27(4), 173–182.
  • Alacam, E. (1998). Karnivorlarda üreme süreci ve sorunları, In H.Y. Imren (Ed). Kedi ve Köpek Hastalıkları, pp437-512. Ankara, Türkiye: Medisan.
  • Althausen, T. L., & Thoenes, E. (1932). Influence on carbohydrate metabolism of experimentally induced hepatic changes: II. Phosphorus poisoning. Archives of Internal Medicine, 50(1), 58-75.
  • Asheim, A. (1964). Renal function in dogs with pyometra. 7. Calcium and potassium levels in dogs with pyometra and polyuria. Acta Veterinaria Scandinavica, 5, 115-122.
  • Borresen, B., & Skrede, S. (1980). Pyometra in the dog- a pathophysiological investigation V. The presence of intrahepatic cholestasis and an "acute phase reaction". Nordisk Veterinærmedicin,32(9), 378-386.
  • Chung, P. Y., Sitrin, M. D., & Te, H. S. (2003). Serum phosphorus levels predict clinical outcome in fulminant hepatic failure. Liver Transplantation, 9(3), 248-253.
  • Comazzi, S., Pieralisi, C., & Bertazzolo, W. (2004). Haematological and biochemical abnormalities in canine blood: frequency and associations in 1022 samples. Journal of Small Animal Practice, 45(7), 343–349.
  • Enginler, S. O., Ateş, A., Diren Sığırcı, B., Sontaş, B. H., Sönmez, K., Karaçam, E., Ekici, H., Evkuran Dal, G., & Gürel, A. (2014). Measurement of C-reactive protein and prostaglandin F2α metabolite concentrations in differentiation of canine pyometra and cystic endometrial hyperplasia/mucometra. Reproduction in Domestic Animals, 49(4), 641–647.
  • Fantoni, D.T., Auler Junior, J.O., Futema, F., Cortopassi, S.R., Migliati, E.R., Faustino, M., & De Oliveira, C.M. (1999). Intravenous administration of hypertonic sodium chloride solution with dextran or isotonic sodium chloride solution for treatment of septic shock secondary to pyometra in dogs. Journal of the American Veterinary Medical Association, 215(9), 1283-1287.
  • Günay Uçmak, Z., Küçükbekir, Ç.N.& Uçmak, M. (2019, April, 17-19). A case of pyometra in five month old queen. Paper presented at the 21st International Veterinary Medicine Student Scientific Research Congress. İstanbul, Turkey.
  • Hagman, R. (2012). Clinical and molecular characteristics of pyometra in female dogs. Reproduction in Domestic Animals, 47, 323-325.
  • Hagman, R., Holst, B. S., Möller, L., & Egenvall, A. (2014). Incidence of pyometra in Swedish insured cats. Theriogenology, 82(1), 114-120.
  • Hagman, R. (2022). Pyometra in Small Animals 2.0. Veterinary clinics of North America. Small Animal Practice, 52(3), 631–657.
  • Hollinshead, F., & Krekeler, N. (2016). Pyometra in the queen: To spay or not to spay? Journal of Feline Medicine and Surgery, 18(1), 21–33.
  • Johnson, C. A. (1994). Female reproduction and disorders of the female reproductive tract. The cat: Diseases and clinical management (Sherding RG, Ed.), Saunders, Philadelphia, 1855-1876.
  • Johnston, S. D., Root Kustritz, M. V., & Olson, P. S. (2001). Canine and feline theriogenology. Saunders.
  • Kenney, K. J., Matthiesen, D. T., Brown, N. O., & Bradley, R. L. (1987). Pyometra in cats: 183 cases (1979-1984). Journal of the American Veterinary Medical Association, 191(9), 1130–1132.
  • Keshavprasad, P. R., Ravikumar, K., Senthilkumar, K., Kathirvel, S., Gopikrishnan, D., Ganesan, A., & Ezakial Napolean, R. (2023). Effect of methylergometrine maleate and mifepristone on uterine biometry and haemato-biochemical changes in canine open cervix pyometra. The Pharma Innovation Journal, 12(1), 1681-1684.
  • King, J. N., Tasker, S., Gunn‐Moore, D. A., & Strehlau, G. (2007). Prognostic factors in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 21(5), 906-916.
  • Koo, O. J., Hong, S. G., Kang, J. T., Park, J. E., Kim, M. J., Jang, G., & Lee, B. C. (2011). Closed-Cervix Pyometra in Young Dogs: 2 Cases. Journal of Embryo Transfer, 26(4), 283-286.
  • Kutzler, M. A., Krekeler, N., & Hollinshead, F. (2012). Pyometra. Small Animal Soft Tissue Surgery, 623-634.
  • Nak, D. (1999). Kedi ve köpeklerde pyometranın fizyopatolojisi, tanısı ve prostaglandinlerle sağaltımı. Yüzüncü Yıl Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 5,79.
  • Nak, D., Misirlioglu, D., Nak, Y., & Keskin, A. (2005). Clinical laboratory findings, vaginal cytology and pathology in a controlled study of pyometra in cats. Australian Veterinary Practitioner, 35(1), 10-14.
  • Verstegen, J., Dhaliwal, G., & Verstegen-Onclin, K. (2008). Mucometra, cystic endometrial hyperplasia, and pyometra in the bitch: advances in treatment and assessment of future reproductive success. Theriogenology, 70(3), 364–374.
  • Vilhena, H., Figueiredo, M., Cerón, J. J., Pastor, J., Miranda, S., Craveiro, H., Pires, M. A., Tecles, F., Rubio, C. P., Dabrowski, R., Duarte, S., Silvestre-Ferreira, A. C., & Tvarijonaviciute, A. (2018). Acute phase proteins and antioxidant responses in queens with pyometra. Theriogenology, 115, 30–37.
  • Werner, L. L., Turnwald, G. H. (1999). Immunologic and plasma protein disorders. In: M.D. Willard, H. Tvedten, G.H. Turnwald (Eds). Small Animal Clinical Diagnosis by Laboratory Methods (pp. 248–264). St Louis, US: W.B. Saunders.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm Araştırma Makaleleri
Yazarlar

Zeynep Günay Uçmak 0000-0003-2530-1291

Sevde İslamoğlu Bu kişi benim 0000-0002-8838-2562

Proje Numarası -
Yayımlanma Tarihi 30 Nisan 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 7 Sayı: 1

Kaynak Göster

APA Günay Uçmak, Z., & İslamoğlu, S. (2023). Changes in phosphorus and some biochemical parameters in cats with open and closed cervix pyometra. Journal of Istanbul Veterinary Sciences, 7(1), 21-26.

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