Effect of homeopathic drug phosphorus 15ch on diethylnitrosamine induced liver injury in rats

Yıl 2025, Cilt: 9 Sayı: 1, 57 - 64, 30.04.2025

Eda Nur Okman , Süleyman Kozat

Öz

In this study, the hepatoprotective and antioxidant effect of the homeopathic drug Phosphorus 15CH on liver injury induced by diethylnitrosamine (DEN) was investigated. Thirty-two Wistar rats were separated into 4 groups, control group, DEN group, DEN+ Phosphorus 15CH group, and Phosphorus 15CH group. In the DEN group, rats were administered with DEN in a single dose of 70 mg/kg once a week for 4 months. For hepatoprotective studies, Phosphorus 15CH was administered daily for 2.5 months. AST, ALT, GGT, Total Bilirubin, LDH and SOD, MDA, and GSH were estimated in serum samples. Administration of DEN caused a significant increase in AST, ALT, GGT, total bilirubin, and LDH. Oxidative stress parameters in DEN treated group showed a significant decrease in their levels. MDA levels were significantly increased by lipid peroxidation in DEN treated group. Based on these results, it was concluded that Phosphorus 15CH has a protective effect on DEN-induced liver injury in rats.

Anahtar Kelimeler

Diethylnitrosamine, Phosphorus 15CH, Homeopathy, Liver injury

Destekleyen Kurum

VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ BİLİMSEL ARAŞTIRMA PROJELERİ KOORDİNASYON BİRİMİ

Proje Numarası

TDK-2020-8376

Effect of homeopathic drug phosphorus 15ch on diethylnitrosamine induced liver injury in rats

Öz

Proje Numarası

TDK-2020-8376

Kaynakça

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