Does Exercise Effect on Mitochondrial Dysfunction and Insulin Sensitivity?

Yıl 2017, , 31 - 37, 28.12.2017

Aslı Devrim , Pelin Bilgiç

https://doi.org/10.21020/husbfd.341817

Cited By: 1

Öz

Skeletal muscle has an important role in the
pathogenesis of insulin resistance. Several studies have found that insulin
action may be related to the oxidative capacity of skeletal muscle. Aerobic
exercises improve both insulin sensitivity and activity of oxidative enzymes in
muscle. Individuals having disorders and diseases like insulin resistance, obesity
or type 2 diabetes were found to have lower muscle oxidative enzyme activity. Some
hypotheses have been developed regarding the hypothesis that insulin infusion
stimulates the mitochondrial protein synthesis rate in skeletal muscle. The effects
of exercise on mitochondrial dysfunction and insulin sensitivity are summarized
and discussed in this review.

Anahtar Kelimeler

Insulin sensitivity, mitochondrial dysfunction, exercise

Egzersiz, İnsülin Duyarlılığı ve Mitokondriyal Fonksiyonu Etkiler Mi?

Öz

İskelet kası
insülin direnci patogenezinde önemli rol oynamaktadır. Yapılan çalışmalarda,
vücuttaki insülin hareketlerinin iskelet kası oksidatif kapasitesi ile ilişkili
olabileceği bulunmuştur. Aerobik egzersizler hem insülin duyarlılığı hem de kas
oksidatif enzim aktivitesini arttırmaktadır. Kas oksidatif enzim aktivitesinin obezite,
insülin direnci veya tip 2 diyabet gibi kronik hastalıkları olan bireylerde daha
düşük olduğu saptanmıştır. İnsülin infüzyonunun iskelet kasındaki mitokondriyal
protein sentez hızını da uyardığıyla ilgili hipotezler bulunmaktadır. Bu
derlemede, egzersizin mitokondriyal disfonksiyon ve insülin duyarlılığı üzerine
etkisini araştıran yayınları değerlendirilerek özetlenmiştir.

Anahtar Kelimeler

İnsülin duyarlılığı, mitokondriyal disfonksiyon, egzersiz

Kaynakça

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