Kurkuminin Aflatoksin B1 ile İndüklenen Wistar-Albino Ratlarda Nefrotoksisite Üzerindeki İyileştirici Etkileri

Abstract

Gıda yoluyla maruz kalınan mikotoksinler, organ fonksiyon bozukluğuna ve hatta yetmezliğe yol açabilir. Aflatoksin B1'in (AFB1) neden olduğu böbrek yetmezliği ile ilgili çalışmaların sayısı sınırlıdır. Bu araştırmanın amacı, AFB1'in böbrek üzerindeki etkisini ve olası zararlı etkisinin geleneksel olarak kullanılan ve ekonomik bir antioksidan olan kurkumin tarafından önlenip önlenemeyeceğini incelemekti. 38 rat beş gruba ayrıldı, grup I kontrolü temsil ederken diğerleri sırasıyla dimetilsülfoksit (D), kurkumin (Cur), AFB1 (AF) ve AFB1 + Kurkumin (AF+Cur) olarak adlandırıldı. Her gruptan 60 gün sonra plazma örnekleri alındı. Daha sonra ELISA yöntemi ile BUN, ürik asit ve kreatinin düzeyleri belirlendi. Veriler istatistiksel olarak analiz edildi. Çalışmanın sonunda vücut ağırlığı artışı en az AFB1 uygulanan gruptaydı. Ayrıca bu grupta BUN, ürik asit ve kreatinin seviyeleri diğer gruplara göre daha yüksekti. AFB1 ve kurkuminin birlikte uygulanması hem vücut ağırlığı artışını hem de BUN, ürik asit ve kreatinin düzeylerini iyileştirdi. Bu nedenle kurkumin, mikotoksinlerin, özellikle AFB1'in neden olduğu böbrek yetmezliğinin önlenmesinde düşük maliyetli, yüksek etkili bir böbrek koruyucu ajan olarak kabul edilebilir.

Keywords

• Aflatoksin B1
• Kurkumin
• Böbrek Hasarı
• Rat

Project Number

18102035

Ameliorative Effects of Curcumin on Aflatoxin B1-Induced Nephrotoxicity in Wistar-Albino Rats

Abstract

Mycotoxins exposed through food can lead to organ dysfunction and even failure. The number of studies on renal failure induced by aflatoxin B1 (AFB1) is limited. The purpose of this trial was to examine the effect of AFB1 on the kidney and whether its possible deleterious effect could be prevented by curcumin, a traditionally used and economical antioxidant. 38 rats were divided into five groups, group I represented the control, while the others were named dimethylsulfoxide, curcumin, AFB1, and AFB1 + Curcumin, respectively. Plasma samples were taken from each group after 60 days. Then, BUN, uric acid, and creatinine levels were determined by the ELISA method. Data were analyzed statistically. Bodyweight gain at the end of the study was the least in the group administered AFB1. Also, BUN, uric acid, and creatinine levels were higher in this group than in the other groups. Concomitant administration of AFB1 and curcumin improved both body weight gain and BUN, uric acid, and creatinine levels. Therefore, curcumin can be considered as a low cost-high efficacy renal protective agent in the prevention of renal failure caused by mycotoxins, especially AFB1.

Keywords

• Aflatoxin B1
• Curcumin
• Kidney injury
• Rat

Supporting Institution

Selcuk University Scientific Research Projects Coordination Office

Project Number

18102035

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