Kısırlaştırılan Kedilerde Krom Pikolinatın Ağırlık Artışı, Morfometrik Ölçümler ile Kan Lipid ve Leptin Seviyelerine Etkisi

Yıl 2017, , 25 - 31, 30.06.2017

Öznur Aslan Kutlay Gürbulak Fatma Uyanık Yücel Çam Kazım Güvenç

https://doi.org/10.31196/huvfd.325699

Öz

Çalışmanın amacı,
kısırlaştırılmış kedilerde krom pikolinatın (CrPic) morfometrik parametreler,
ağırlık artışı ile serum lipit ve leptin seviyeleri üzerine etkisinin
belirlenmesidir. Kısırlaştırılıp, 2 ay adaptasyon süresini takiben çalışmaya
dahil edilen 32 (22 dişi ve 10 erkek) adet, yaşları 1-5 arasında değişen ve
ağırlık ortalaması 3021 ± 453 g olan kediler 4 gruba ayrıldı. Kontrol grubu
olarak tutulan kediler (Kontrol I), günlük enerji gereksinimi (60 kcal ME/kg)
hesaplanarak ticari kuru mama ile beslendi. Ad-libitum beslenen diğer gruptaki
kedilere sırasıyla CrPic kapsülden 0 (Kontrol II), 200 ya da 600 µg Cr/gün, 16
hafta süreyle uygulandı. En fazla ağırlık artışının belirlendiği Kontrol II’de,
deri kalınlığı, abdominal çevre ve leptin düzeyinde düşük oranda bir artış
gözlenirken, vücut kitle indeksi (BMI) ve göğüs çevresindeki artış önemli
bulundu (P<0.05). CrPic verilen gruplarda ise bu değişkenlerdeki azalma önemli
değildi. Plazma leptin seviyesi ile vücut ağırlığı (r = 0.510, P<0.01) ve
aterojenik indeks (AI) arasında pozitif korelasyon (r = 0.479, P<0.05)
belirlenirken, Cr arasında negatif korelasyon (r = -0.445, P<0.05)
belirlendi. Kontrol II’de trigliserit (TG), total kolesterol (TC), düşük
dansiteli lipoprotein (LDL), LDL ve yüksek dansiteli lipoprotein (HDL)  oranı ve AI değerleri en yüksek seviyede
olmakla birlikte, gruplar arasında fark gözlenmedi. Krom ilavesinin de bu
parametrelere önemli bir etkisinin olmadığı saptandı.  Serum Cr ve total kolesterol düzeyleri
arasında negatif ilişki belirlendi (r = -0.468, P<0.05). Sonuç olarak,
kısırlaştırıldıktan sonra ad-libitum beslenen tüm gruplarda canlı ağırlık, BMI,
deri altı yağ doku ve plazma leptin seviyesinde artış belirlenirken, krom
ilavesinin bu parametrelere önemli bir etkisinin olmadığı belirlendi.

Anahtar Kelimeler

Kedi, Krom, Morfometrik ölçüm, Leptin, Lipit

Effects of Chromium Picolinate on Weight Gain, Morphometric Measurements and, Blood Lipid and Leptin Levels in Gonadectomized Cats

Öz

The
aim of this study was determined to the effects of chromium picolinate (CrPic)
on morphometric measurements, weight gain, and serum lipid and leptin levels in
gonadectomized cats. Thirty two (22 female, 10 male), aged 1-5 years, weighing
3021 ± 453 g, were evenly distributed into four groups following a two month
adaptation period after gonadectomy. Cats in one group was kept as control (Control
I) and fed commercial dry cat food at the amount providing the daily
requirements of 60 kcal ME/kg body weight. Cats in the remaining groups fed ad-libitum and supplemented daily with either 0
(Control II), 200 or 600 µg Cr/day as CrPic capsules for 16 weeks. The most
marked increase in weight gain was determined in Control II in which significant
increase was observed in chest circumference and body mass index (BMI) (P<0.05)
whereas slightly increased levels were reported in Skinfold thickness,
abdominal circumference and leptin levels. On the other hand, in the CrPic groups
(200 and 600 µg/day) the reported decrease in these variables were not
significant. Positive correlations were found between weight gain and plasma
leptin (r = 0.510, P<0.01) and leptin and atherogenik indeks (AI) (r = 0.479,
P<0.05) while Cr negatively correlated with leptin (r = -0.445, P<0.05). Although
differences between groups were not significant, the highest values were
determined in Control II regarding triglycerides (TG), total cholesterol (TC), low
density lipoprotein (LDL), LDL to high density lipoprotein (HDL) ratio and AI. It
was determined that chromium supplementation did not have significant effect on
these parameters. Negative relationship was determined between serum Cr and TC
(r = -0.468, P<0.05). In conclusion, in all groups ad-libitum feeding after
gonadectomy resulted to increased weight gain, BMI, subcutaneous fat deposition
and plasma leptin level. There is no effect in these parameters of chromium
supplementation.

Anahtar Kelimeler

Cat, Chromium, Morphometric measurements, Leptin, Lipid

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