Endokannabinoidler ve Alzheimer

Yıl 2018, Cilt: 3 Sayı: 1-2, 21 - 24, 04.04.2019

Şükran Şeyma Yılmaz Melike Rana Gözübek Oytun Erbaş

Öz

Anandamid ve 2-araşidonil gliserol olmak üzere iki tip endokannabinoid vardır. Etkilerini kannabinoid tip 1 reseptör ve kannabinoid tip 2 reseptör üzerinden gösterirler. Beyinde korteks, hipokampus, beyincik, beyin sapı ve bazal gangliyonlarda bulunurlar. Nörodejeneratif hastalıklar temelde mikroglianın kronik enflamasyonuyla ortaya çıkarlar, endokannabinoidlerin de bu enflamasyon üzerine nöroprotektif etkileri vardır. Bu derlemede, endokannabinoidlerin Alzheimer hastalığı üzerindeki etkileri incelendi.

Anahtar Kelimeler

Alzheimer hastalığı, endokannabinoid, nöroprotektif

Kaynakça

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