EFFECT OF CENTRAL SENSITIZATION ON DISEASE SEVERITY AND QUALITY OF LIFE IN FIBROMYALGIA SYNDROME

Öz

The negative effects of central sensitization on various chronic painful conditions are known. However, there is no study that has investigated the clinical effects of central sensitization in Fibromyalgia Syndrome (FMS) in detail. The aim of our study was to investigate the effects of central sensitization on disease severity and quality of life in FMS. Within the framework of this purpose, 51 individuals with FMS were included in the study. Individuals with FMS were divided into subgroups according to their Central Sensitization Inventory (CSI) scores. The disease severity of all individuals was measured using the Revised Fibromyalgia Questionnaire. Their quality of life was measured using the Short Form-12 Health Survey. As a result of the grouping, 3 of the individuals with FMS had subclinical, 6 had mild, 11 had moderate, 13 had severe, and 18 had very severe central sensitization. When these groups were investigated, significant differences were found between the mild-very severe and subclinical-very severe groups in terms of disease severity and mental component of quality of life (p<0.05). No difference was found between the other groups (p<0.05). These findings show that central sensitization has an important place in FMS and other chronic painful disorders. Therefore, it is thought that more effective treatment can be provided by considering central sensitization in the assessment. Individual and multimodal methods are among the main treatment strategies recommended for the management of central sensitization. In future studies, the effects of these treatment strategies on central sensitization can be investigated.

Anahtar Kelimeler

• Pain
• Chronic Pain
• Central Sensitization
• Fibromyalgia Syndrome

FİBROMİYALJİ SENDROMUNDA SANTRAL SENSİTİZASYONUN HASTALIK ŞİDDETİ VE YAŞAM KALİTESİ ÜZERİNDEKİ ETKİSİ

Öz

Santral sensitizasyonun farklı kronik ağrılı durumlardaki olumsuz etkisi bilinmektedir. Buna rağmen santral sensitizasyonun Fibromiyalji Sendromu’nda (FMS) klinik etkilerini detaylı olarak inceleyen herhangi bir çalışma bulunmamaktadır. Çalışmamızın amacı, FMS’de santral sensitizasyonun hastalık şiddeti ve yaşam kalitesi üzerindeki etkisini incelemektir. Bu amaç çerçevesinde, çalışmaya 51 FMS’li birey dahil edildi. FMS’li bireyler, Santral Sensitizasyon Envanteri (SSE) puanlarına göre alt gruplara ayrıldı. Tüm bireylerin hastalık şiddetleri Revize Fibromiyalji Anketi kullanılarak ölçüldü. Yaşam kaliteleri ise Kısa Form-12 Sağlık Anketi ile ölçüldü. Yapılan gruplandırma sonucunda, FMS’li bireylerden 3’ü subklinik, 6’sı hafif, 11’i orta, 13’ü şiddetli ve 18’i ise çok şiddetli seviyede santral sensitizasyona sahipti. Bu gruplar incelendiğinde, hafif-çok şiddetli ve subklinik-çok şiddetli seviyedeki gruplar arasında hastalık şiddeti bakımından ve yaşam kalitesinin mental bileşeni bakımından anlamlı farklılıklar tespit edildi (p<0,05). Diğer gruplar arasında bir farklılığa rastlanılmadı (p<0,05). Bu bulgular, santral sensitizasyonun FMS’de ve diğer kronik ağrılı rahatsızlıklarında önemli bir yeri olduğunu göstermektedir. Bu nedenle değerlendirmede santral sensitizasyonun dikkate alınması ile daha etkin tedavinin sağlanabileceği düşünülmektedir. Santral sensitizasyonun yönetiminde önerilen başlıca tedavi stratejileri arasında bireysel ve multimodal yöntemler yer almaktadır. Gelecekteki çalışmalarda, bu tedavi stratejilerinin santral sensitizasyon üzerindeki etkileri incelenebilir.

Anahtar Kelimeler

• Ağrı
• Kronik Ağrı
• Santral Sensitizasyon
• Fibromiyalji Sendromu

Kaynakça

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