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DOKSORUBİSİN KARDİYOTOKSİSİTESİNİN OLUŞUMU VE ÖNLENMESİ

Yıl 2021, Cilt: 4 Sayı: 1, 1 - 15, 30.05.2021
https://doi.org/10.52538/iduhes.827754

Öz

Yüksek antineoplastik aktiviteleri nedeniyle onkolojide en sık kullanılan antrasiklinler arasında yer alan doksorubisin; göğüs, over, testis, tiroid, akciğer kanserlerinde ve birçok sarkomun tedavisinde klinik uygulaması olan önemli ilaçlardan biridir. Ancak doksorubisinin klinik kullanımını kısıtlayan önemli ve ciddi kardiotoksik yan etkisi vardır. Bu derlemede kardiotoksik etki mekanizmasının araştırılması amaçlandı. Araştırma sonucunda kardiotoksisite oluşumunda; nükleik asit ve protein sentezinin inhibisyonu, vazoaktif aminlerin salınımı, mitokondriyal membran potansiyelinde kayıp ve elektron trasport zincirinin inhibisyonu, adrenerjik fonksiyonlardaki değişiklikler, adenilat siklaz, Na+-K+ ATPaz ve Ca+ ATPaz aktivitelerinin azalması gibi mekanizmalar etkili olsa da oksidatif stres ve apoptozisin asıl etken olduğu görülmüştür. Doksorubisinin oluşturduğu kardiotoksisiteyi azaltmaya yönelik koruyucu maddeler araştırmalarda kullanılmış olsa da bu maddelerin klinikte kullanımları yeterli düzeylere ulaşılabilmiş değildir. Yapılan literatür taraması sonucunda, Doksorubisinin oluşturduğu kardiotoksisiteyi azaltmaya yönelik daha ayrıntılı çalışmaların yapılması gerektiği kanaatine varılmıştır.

Destekleyen Kurum

YOK

Proje Numarası

YOK

Kaynakça

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Toplam 71 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Eczacılık ve İlaç Bilimleri
Bölüm Makaleler
Yazarlar

Zeynep Erdoğmuş Özgen 0000-0001-6607-836X

Proje Numarası YOK
Yayımlanma Tarihi 30 Mayıs 2021
Gönderilme Tarihi 18 Kasım 2020
Yayımlandığı Sayı Yıl 2021 Cilt: 4 Sayı: 1

Kaynak Göster

APA Erdoğmuş Özgen, Z. (2021). DOKSORUBİSİN KARDİYOTOKSİSİTESİNİN OLUŞUMU VE ÖNLENMESİ. Izmir Democracy University Health Sciences Journal, 4(1), 1-15. https://doi.org/10.52538/iduhes.827754

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