Synthesis and Characterization of Metal Carbonyls [M(CO)6 (M= Cr, Mo,W), Re(CO)5Br] with Indole -3-carboxyaldehydemethanesulfonylhydrazone

Öz

Abstract

Four new complexes, M(CO)₅(inmsh) (M=Cr(1), Mo(2),W(3)) and Re(CO)₄Br(inmsh) (4), were synthesized by the photochemical reaction of metal carbonyls with indole-3-carboxyaldehydemethanesulfonyl hydrazone(inmsh) and characterized by using elemental analysis, ¹H NMR, LC-MS and IR spectra. The spectroscopic studies show that inmsh behaves as a monodantate ligand coordinating via imine N donor atom in [M(CO)₅(inmsh)] (M=Cr, Mo, W) and Re(CO)₄Br(inmsh).

Anahtar Kelimeler

• Sulfonylhydrazones,Metal Carbonyls

Synthesis and Characterization of Metal Carbonyls [M(CO)6(M = Cr,Mo,W)] with Indole -3-carboxyaldehydemethanesulfonylhydrazone

Öz

Four new complexes, [M(CO)5(msh4)](Cr(1),Mo(2),W(3)),and Re(CO)4Br(inmsh)(4),were synthesized by the photochemical reaction of metal carbonyls with indole-3 carboxyaldehydemethanesulfonyl hydrazone(inmsh) and characterized by using elemental analysis, 1H NMR, EI-MS and IR spectra. The spectroscopic studies show that
inmsh behaves as a monodantate ligand coordinating via imine N donor atom in [M(CO)5(inmsh)](M = Cr,Mo,W) and Re(CO)4Br(inmsh). The sulfonamides (−SO2NH−) are used widely as antibacterial agents because of their lower cost, lower activity and most activity against bacterial diseases[1]. Sulfo drugs are used as chemotherapeutic agents with large spectrum of activity and they are used today for various bacterial, protozoal and fungal infections[2a,b]. Methane sulfonamide derivatives possess DNA-binding ability and show cytostatic effects which have usage in cancer chemotherapy. Sulfonylhydrazones derived from sulfonamides have pharmacological properties as antibacterial, antitumor, divretic, antiviral, antinociceptive activity and enzym inhibition especially to carbonic anhydrase species[3,4]. Many of the physiologically active hydrazones have applications in the treatment of illness like tuberculosis, leprosy and mental damage

Anahtar Kelimeler

• Metal Carbonyls
• Sulfonylhydrazones
• Photochemical Reactions

Kaynakça

1. S.Özçelik, M.Dinçer, M.Şekerci, A.Balaban, Ü.Özdemir, Acta Crystallogr Sect.E 60:1552-1553(2004).
2. H.Alyar, S.Alyar, A.Ünal, N.Özbek, N.Karacan, J.Mol.Struct 1028:116-125(2012)
3. H.Alyar, A.Ünal, N.Özbek, S.Alyar, N.Karacan, Spectrochim Acta A 98:329-336(2012).
4. N.I.Dodoff, Ü.Özdemir, N.Karacan, M.Georgieva, S.M.Konstantinov, M.E.Stefanova, Z.Naturforsch, 54:1553-1562(1999).
5. Ü.Özdemir, F.Arslan, F.Hamurcu, Spectrochim Acta A 75: 121-126(2010).
6. S.W.Kirtley, In Comprehensive Organometallic Chemistry, G.Wilkinson, F.G.A.Stone, E.W.Abel(Eds), p. 1079, Pergamon Press, Oxford (1982).
7. A.S.Cavallo, G.Solladie, E.Tsano, J. Organomet. Chem., 144, 181(1978).[7]R.Lal De, K.Samanta (nee Bera), I. Banerjee, Indian J. Chem., 40A,144(2001).
8. W. Kaim, S.Kohlmann, Inorg. Chem., 26, 68(1987). [9]B.M.Trost, M.Lautens, J. Am .Chem. Soc.,104, 5543 (1982); 105, 3343 (1982).

9. B.J.Brisdon, D.W.Brown, C.R.Wills, Polyhedron, 5, 439(1986).
10. A.B.Gündüzalp, Ü.Ö.Özmen, B.S.Çevrimli, S.Mamaş, S.Çete, Med. Chem. Res. 23:3255-3268(2014).
11. F.Sarıkahya, O.S.Şentürk, Synth. React. Inorg. Met.-Org. Chem., 31, 1843(2001).
12. F.A.Cotton, G.Wilkinson, Advanced Inorganic Chemistry, 5th Ed.1047(1988).
13. J.E.Kovacic, Spectrochim.Acta 23A,183(1967).[15]G.L.Mieddler, D.A.Tarr, Inorganic Chemistry, 2nd Ed.,471(2000).