OBSTRÜKTİF UYKU APNE ŞİDDETİ İLE DERİVED PLATELET-LENFOSİT RATİO ARASINDAKİ İLİŞKİ

Öz

Amaç: Bu çalışmada Platelet-lenfosit ratio (PLR) formülünden revize edilerek hesapladığımız derived PLR’nin (dPLR)ile Obstrüktif Uyku Apne (OUA) şiddetini yansıtmadaki olası rolünü araştırmayı amaçladık. Gereç ve Yöntem: Bu çalışmaya yeni teşhis almış 104 OUA hastası ve 65 sağlıklı kontrol olgusu alındı. Demografik veriler çalışma formuna kaydedildi. Tüm hastalara tüm gece polisomnografi işlemi uygulandı. Hastaların tam kan sonuçları kaydedildi. Bulgular: Hastaların yaş ortalaması OUA grubunda 52,4±12,2 yıl idi. OUA grubunda hastaların %65’i erkek, %35’ü kadın idi. Hasta ve kontrol grupları arasında yaş, cinsiyet ve sigara içimi açısından anlamlı fark yoktu (p>0,05). OUA grubunda ortalama apne-hipopne indeksi 32,5 adet/saat idi. OUA grubunda ortalama dPLR değeri 83,1±33,9 iken kontrol grubunda 70,0±25,1 olarak saptandı ve aradaki fark anlamlı olarak daha yüksekti (p=0.008). Hafif, orta ve ağır OUA grupları arasında dPLR değerleri sırasıyla 71,6, 86,2 ve 89,9 olarak saptandı ve aradaki fark anlamlıydı (p<0,05). Sonuç: dPLR tam kan ölçümüyle kolayca elde edilebilen, herkesin ulaşabileceği bir hemogram parametresidir. dPLR oranının OUA hastalığının şiddetini yansıtmada potansiyel bir rol oynayabileceği düşünüldü.

Anahtar Kelimeler

• Obstrüktif uyu apnesi, inflamasyon, platelet, lenfosit

RELATIONSHIP BETWEEN DERIVED PLATELET-LYMPHOCYTE RATIO AND SEVERITY OF OBSTRUCTIVE SLEEP APNEA

Öz

Aim: In this study we aimed to investigate relationship derived Platelet - lymphocyte ratio (dPLR) revised from PLR formula and its possible role in reflecting the severity of OSA. Material and Methods: This study enrolled 104 newly diagnosed OSA patients and 65 healthy control subjects. Demographic data was recorded in the study form. All patients underwent overnight polysomnography process. Complete blood test results were recorded. Results: The average age of the patients was 52.4 ± 12.2 years in the OSA group.In the OSA group 65% of patients were male and 35% female. Between the patient and control groups in age, gender and smoking had no significant difference (p> 0.05). Average apnea- hypopnea index was 32.5 units/hour in the OSA group. While average dPLR values in the OSA group was 83.1 ± 33.9, in the control group found to be 70.0 ± 25.1 and the difference was significant (p=0.008). Between mild, moderate and severe OSA groups dPLR values were found to be 71.6, 86.2 and 89.9 respectively and the difference was statistically significant (p

Anahtar Kelimeler

• Obstructive sleep apnea, inflammation, platelet, lymphocyte

Kaynakça

1. 1. Lattimore JD, Celermajer DS, Wilcow I. Obstructive sleep apnea and cardiovascular disease. J Am Coll Cardiol 2003; 41: 1429-37.
2. 2. Dursunoglu D, Dursunoglu N. Cardiovascular diseases in obstructive sleep apnea. Tuberk Toraks 2006; 54: 38-96.
3. 3. Shetty GK, Economides PA, Horton ES, Mantzoros CS, Veves A. Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care 2004; 27:2450– 7.
4. 4. Jennings LK. Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis. Thromb Haemost 2009; 102:248–57.
5. 5. Dotsenko O, Chaturvedi N, Thom SA, et al. Platelet and leukocyte activation, atherosclerosis and inflammation in European and South Asian men. J Thromb Haemost 2007; 5:2036–42.
6. 6. Wang D, Yang JX, Cao DY. Preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma. Onco Targets Ther 2013; 6: 211–6.
7. 7. Bhat T, Teli S, Rijal J. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013; 11: 55–9.
8. 8. Proctor MJ, McMillan DC, Morrison DS. A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer. Br J Cancer 2012; 107: 695–9.

9. 9. Koseoglu HI, Altunkas F, Kanbay A, Doruk S, Etikan I, Osman Demir. Platelet-lymphocyte ratio is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome. J Thromb Thrombolysis 2015; 39: 179–85.
10. 10. Koseoglu S, Ozcan KM, Ikinciogullari A, et al. Relationship Between Neutrophil to Lymphocyte Ratio,Platelet to Lymphocyte Ratio and Obstructive Sleep Apnea Syndrome. Adv Clin Exp Med 2015; 24: 623–7.
11. 11. Günbatar H, Ekin S, Sünnetçioğlu A, et al. The relationship between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with obstructive sleep apnea syndrome. Dicle Tıp Dergisi 2015; 42: 289-93.
12. 12. Belaj K, Pichler M, Hackl G, et al. Association of the Derived Neutrophil–Lymphocyte Ratio With Critical Limb Ischemia. Angiology 2016; 67:350- 4.