AĞIR ALLERJİK ASTIMDA 1 YILLIK ANTİ-IGE (OMALİZUMAB) DENEYİMİMİZ

Öz

Amaç: Standart tedavilere yanıtsız orta ve ağır alerjik astımda anti IgE (Omalizumab) tedavisinin etkili ve yararlı olduğu bilinmektedir. Bu çalışmada omalizumab tedavisi uyguladığımız alerjik astımlı hastalarımızın verilerinin paylaşılması amaçlandı. Yöntem ve Gereç: Kliniğimizde omalizumab tedavisi uygulanan ağır alerjik astımlı 23 hastanın dosya kayıtları ve bilgi formları retrospektif olarak incelendi. Allerjen duyarlılığı deri prik testi ile saptandı. Omalizumab tedavisi öncesi ve tedavinin 1.yılı sonundaki serum total IgE, Astım Kontrol Testi, kullanılan ilaç sayısı, acil başvurusu, FEV1, FEV1/FVC değerleri karşılaştırıldı. Bulgular: Yaş ortalaması 45.78±10.71 yıl, hastalık süresi ortalaması 13.69±9.04 yıl olan 23 hastanın %69.6’sı kadın (n=16) idi. Astıma ek olarak hastaların %65.2’sinde alerjik rinit, %34.8’indeürtiker, %13’ünde ilaç allerjisi, %8.7’sinde gıda allerjisi, %4.3’ünde latex allerjisi vardı. Ev tozu akarı duyarlılığı %78.3, ev tozu akarı + diğer inhalan allerjen duyarlılığı %21.7 idi. Omalizumab tedavisinin 1.yılı sonunda kullanılan astım ilaçları sayısında, acil başvurusunda, serum total IgE ve FEV1/FVC’de azalma (P<0.05), astım kontrol testi puanlarında artma (P<0.05) saptandı. Sonuç: Hastalarımızda omalizumab tedavisinin etkili ve güvenli olduğu, iyi tolere edildiği görüldü. Standart tedavilerle kontrol sağlanamayan ağır alerjik astımlı hastalarda omalizumab tedavisinin yararlı olduğunu düşünmekteyiz.

Anahtar Kelimeler

• Astım, omalizumab, allerji

OUR ANTI-IGE (OMALIZUMAB) EXPERIENCE IN SEVERE ALLERGIC ASTHMA: 1ST YEAR EXPERIENCE

Abstract

Aim: Anti-IgE (omalizumab) therapy is known to be effective and useful in moderate to severe allergic asthma without response to standard treatments. This study aimed to share the data of our allergic asthmatic patients with omalizumab treatment. Material and Methods: The records and data sheets of 23 patients with severe allergic asthma who underwent omalizumab treatment were retrospectively reviewed in our clinic. Sensitivity to allergen was detected by skin prick test. Serum total IgE, Astma Control Test, number of medications used, urgent admission, FEV1, FEV1 / FVC values were compared before and after omalizumab treatment. Results: The mean age was 45.78 ± 10.71 years and the mean time of ilness of the patients were 13.69 ± 9.04 years. Of the 23 patients, 69.6% were female (n = 16). In addition to asthma, 65.2% of patients had allergic rhinitis, 34.8% had urticaria, 13% had drug allergy, 8.7% had food allergy, and 4.3% had latex allergies. House dust mite sensitivities were 78.3%, house dust mite + other inhaled allergen sensitivities were 21.7%. The number of asthma medications, serum total IgE and FEV1 / FVC decreased (P <0.05) andasthma control test scores increased (P <0.05) at the end of the 1st year of omalizumab treatment. Conclusion:It has been shown that omalizumab treatment is effective and safe and well tolerated in our patients. We think that omalizumab treatment is useful in patients with severe allergic asthma who can not be controlled by standard treatments.

Keywords

• Asthma, omalizumab, allergy

Kaynakça

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