ASTIM VE KOAH AKUT ATAKLARINDA ELEKTROLİT DENGESİZLİKLERİ

Yıl 2003, Cilt: 17 Sayı: 1, 7 - 10, 01.05.2003

Uğur Gönlügür İnan Erdoğan Levent Özdemir İbrahim Akkurt Ahmet Aker

Öz

Obstrüktif akci¤er hastal›klar›n›n seyrinde elektrolit
dengesizli¤i meydana gelebilmektedir. Bu dengesizlikler
havayolu disfonksiyonuna veya solunum
kas zay›fl›¤›na neden olabilmektedir. Çal›flmam›zda
ast›m ve kronik obstrüktif akci¤er hastal›¤›
(KOAH) akut ataklar›nda elektrolit profillerini
araflt›rd›k. KOAH akut ata¤› ve solunum yetmezli¤i
olan 35 olgu, ast›m ata¤› olan 27 olgu ve
pulmoner semptom tan›mlamayan enfeksiyon
bulgusu olmayan 15 kontrol olgusu çal›flmaya dahil
edildi. Hastaneye yatt›ktan sonraki 24 saat içinde
sodyum, potasyum, klor, fosfor, magnezyum, arter
kan› pH, total ve iyonize kalsiyum, total protein ve
albümin düzeyleri ölçüldü. Ast›m atak olgular›n›n
kontrol olgular›ndan daha düflük albümin ve total
protein düzeyleri vard› (p<0.01). KOAH’l› olgular
ast›ml›lardan daha düflük pH ve magnezyum
ancak daha yüksek iyonize kalsiyum düzeylerine
sahiptiler (p<0.01). Tüm grupta pH ile serum
magnezyum düzeyleri aras›nda pozitif korelasyon
vard› (p<0.01). Ast›ml› olgulardaki azalm›fl albumin
düzeyi ileri yafla, akut faz yan›t›na veya bronfllardaki
artm›fl vasküler permeabiliteye; KOAH‘l› olgulardaki
düflük magnezyum, yüksek iyonize kalsiyum
düzeyleri ise solunumsal asidoza bağlı olabilir.

Anahtar Kelimeler

Elektrolit, astım, KOAH

ELECTROLYTE DISTURBANCES IN EXACERBATIONS OF ASTHMA AND COPD

Öz

Electrolyte disturbances can occur in the course
of obstructive lung diseases. These anomalies
can cause airway dysfunction or respiratory muscle
weakness. We investigated electrolyte profiles in
asthma attacks and chronic obstructive pulmonary
disease (COPD) exacerbations in our study. 35
patients with COPD exacerbations with respiratory
failure, 27 patients with asthma attack, and 15
control patients with no infectious findings and
pulmonary symptoms included the study. Sodium,
potassium, chloride, phosphorus, magnesium, total
and ionized calcium, arterial blood pH, total protein,
albumin levels were measured within the 24 hours
after hospitalization. The patients with asthma
attack had lower total protein and albumin levels
than controls (p<0.01). The patients with COPD
had lower pH and magnesium levels but higher
ionized calcium levels than asthmatics (p<0.01).
There was positive correlation between pH and
serum magnesium levels in the entire group
(p<0.01). Lower levels of albumin in patients with
asthma may be due to higher age, acute phase
response or increase of vascular permeability in
bronchi and lower levels of magnesium and
higher levels of ionized calcium to respiratory
acidosis in COPD patients.

Anahtar Kelimeler

Electrolyte, asthma, COPD

Kaynakça

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