ASTIM VE KOAH AKUT ATAKLARINDA ELEKTROLİT DENGESİZLİKLERİ

Yıl 2003, Cilt: 17 Sayı: 2, 7 - 10, 01.10.2003

Uğur Gönlügür İnan Erdoğan Levent Özdemir İbrahim Akkurt Ahmet Aker

Öz

Obstrüktif akciğer hastalıklarının seyrinde elektrolit dengesizliği meydana gelebilmektedir. Bu dengesizlikler havayolu disfonksiyonuna veya solunum kas zayıflığına neden olabilmektedir. Çalışmamızda astım ve kronik obstrüktif akciğer hastalığı (KOAH) akut ataklarında elektrolit profillerini araştırdık. KOAH akut atağı ve solunum yetmezliği olan 35 olgu, astım atağı olan 27 olgu ve pulmoner semptom tanımlamayan enfeksiyon bulgusu olmayan 15 kontrol olgusu çalışmaya dahil edildi. Hastaneye yattıktan sonraki 24 saat içinde sodyum, potasyum, klor, fosfor, magnezyum, arter kanı pH, total ve iyonize kalsiyum, total protein ve albümin düzeyleri ölçüldü. Astım atak olgularının kontrol olgularından daha düşük albümin ve total protein düzeyleri vardı

Anahtar Kelimeler

Elektrolit, astım, KOAH

ELECTROLYTE DISTURBANCES IN EXACERBATIONS OF ASTHMA AND COPD

Öz

Electrolyte disturbances can occur in the course of obstructive lung diseases. These anomalies can cause airway dysfunction or respiratory muscle weakness. We investigated electrolyte profiles in asthma attacks and chronic obstructive pulmonary disease (COPD) exacerbations in our study. 35 patients with COPD exacerbations with respiratory failure, 27 patients with asthma attack, and 15 control patients with no infectious findings and pulmonary symptoms included the study. Sodium, potassium, chloride, phosphorus, magnesium, total and ionized calcium, arterial blood pH, total protein, albumin levels were measured within the 24 hours after hospitalization. The patients with asthma attack had lower total protein and albumin levels than controls.

Anahtar Kelimeler

Electrolyte, asthma, COPD

Kaynakça

• 1. Fiaccadori E, Coffrini E, Ronda N, et al. Hypophosphatemia in course of obstructive pulmonary disease. Chest 1990; 97: 857-68.
• 2. Gustafson T, Boman K, Rosenhall L, et al. Skeletal muscle magnesium and potassium in asthmatics treated with oral beta 2-agonists. Eur Respir J 1996; 9: 237-40.
• 3. Meehan RT. Renin, aldosterone, and vasopressin responses to hypoxia during 6 hours of mild exercise. Aviat Space Environ Med 1986; 57: 960-5.
• 4. Burtis CA, Ashwood ER. Tietz textbook of clinical chemistry, W.B. Saunders Company, 1986.
• 5. Fahy JV, Wong H, Liu J, Boushey HA. Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects. Am J Respir Crit Care Med 1995; 152: 53-8.
• 6. Kushner I, Rzewnicki DL. The acute phase response: General aspects. Bailliere’s Clin Rheumatol 1994; 8: 513-30.
• 7. Gonlugur U. Eozinofil lökositler, Dilek Ofset Matbaac›l›k, Sivas, 2001, sayfa:212.
• 8. Kalenci S, Kömürcüo¤lu A, Erer OF ve ark. Kronik obstrüktif akci¤er hastal›¤›nda plazma ve eritrosit magnezyum düzeyleri. ‹zmir Gö¤üs Hastanesi Dergisi 1998; 12: 15-8.
• 9. Ryan MF. The role of magnesium in clinical biochemistry: an overview. Ann Clin Biochem 1991; 28: 19-26.
• 10. Milionis HJ, Alexandrides GE, Liberopoulos EN, et al. Hypomagnesemia and concurrent acid-base and electrolyte abnormalities in patients with congestive heart failure. Eur J Heart Fail 2002; 4: 167-73.
• 11. Dai LJ, Friedman PA, Quamme GA. Acid-base changes alter Mg2+ uptake in mouse distal convolutes tubule cells. Am J Physiol 1997; 272: F759-F766.
• 12. Bos WJW, Postma DS, van Doormaal JJ. Magnesiuric and calciuric effects of terbutaline in man. Clin Sci 1988; 74: 595-7.
• 13. Cohen L, Laor A, Shnaider H, Kitzes R. Bone magnesium in chronic obstructive pulmonary disease with hypercapnia. Magnesium 1985; 4: 34-9.
• 14. Fiaccadori E, Del Canale S, Arduini U, et al. Intracellular acid-base and electrolyte metabolism in skeletal muscle of patients with chronic obstructive lung disease and acute respiratory failure. Clin Sci 1986; 71: 703-12.
• 15. Knochel JP. Pathophysiology and clinical characteristics of severe hypophosphatemia. Arch Intern Med 1977; 137: 203-20.
• 16. Haffner CA, Kendall MJ. Metabolic effects of b2- agonists. J Clin Pharm Ther 1992; 17: 155-64.