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Abstract

Asymmetric dimethyl arginine (ADMA) is an endogenous inhibitor of Nitric Oxide Synthase (NOS) enzyme. Methylated arginine has been found in human urine for the first time in the 1970s. However the first study with ADMA has been made among patients with chronic renal failure in 1992. It has been reported by many studies that ADMA contributed in endothelial dysfunction and atherosclerosis and can be used as a marker in recent years. ADMA was found to be elevated in the serum in cases of renal insufficiency, atherosclerosis, hyperglycemia and in hyperhomocysteinemia. In this review we will study ADMA structure, synthesis, metabolism and its relationship with clinical conditions

Keywords

• Asymmetric dimethyl arginine, nitric oxide

Asimetrik Dimetil Arjinin (ADMA) Metabolizması

Öz

Asimetrik dimetil arjinin (ADMA) endojen Nitrik Oksit Sentaz enzimi (NOS) inhibitörüdür. İlk kez 1970 yıllarında metillenmiş arjininler insan idrarında saptanmıştır. Ancak ADMA ile ilgili ilk çalışma 1992’de Vallance ve arkadaşları tarafından kronik böbrek yetmezliği hastalarında yapılmıştır. Son yıllarda yapılan çok sayıda çalışmada ADMA’nın endotel disfonksiyonu ve atherosklerozda rol aldığı ve belirteç olarak kullanılabileceği bildirilmiştir. ADMA’nın ayrıca, böbrek yetmezliği, ateroskleroz, hiperglisemi, hiperhomosisteinemi durumlarında da serumda yükseldiği tespit edilmiştir. Biz bu derlemede ADMA’nın yapısı, sentezi, metabolizması ve klinik durumlar ile ilşkisini inceleyeceğiz.

Anahtar Kelimeler

• Asimetrik dimetil arjinin
• nitrik oksit
• ADMA

Kaynakça

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