Biyomedikal Uygulamalar için Nanoyapılı Bor Bileşikleri: İlaç Dağıtımı, Görüntüleme ve Kanser Tedavisi

Yıl 2025, Sayı: 3, 15 - 27, 31.08.2025

Farah Mutlag , Hussein Elaibi , Ebru Halvacı , Fatih Şen

Öz

Nanoyapılı bor bileşikleri, özellikle ilaç uygulaması, görüntüleme ve kanser tedavisi gibi biyolojik uygulamalarda önemli potansiyele sahip çok işlevli malzemeler olarak ortaya çıkmıştır. Yükseltilmiş yüzey alanı, ayarlanabilir şekil, kimyasal stabilite ve biyouyumluluk gibi ayırt edici fizikokimyasal özellikleri, onları gelişmiş nanotaşıyıcılar ve terapötik ilaçların geliştirilmesi için uygun hale getirir. Yukarıdan aşağıya ve aşağıdan yukarıya prosedürleri kapsayan çeşitli sentez metodolojileri, boyut, şekil ve işlevin titizlikle düzenlenmesine olanak tanır. Bu bileşikler, hedefli ilaç dağıtımında, multimodal görüntüleme için kontrast artırmada ve bor nötron yakalama terapisi (BNCT) dahil olmak üzere tümör seçici tedavilerde etkili işlevsellik sergiler. Ayrıca, tek bir platformda çeşitli terapötik ve tanısal aktiviteleri birleştirme kapasiteleri, onları kombinasyon ve terapötik stratejiler için örnek adaylar haline getirir. Toksisite, düzenleyici çerçeveler ve ölçeklenebilir üretimle ilgili mevcut engellere rağmen, devam eden disiplinlerarası araştırmaların klinik uygulamalarını kolaylaştırması ve özelleştirilmiş tıpta uygulamalarını geliştirmesi beklenmektedir. Bu derlemenin amacı, nanoyapılı bor bileşiklerinin özelliklerini, sentez yöntemlerini, biyomedikal uygulamalarını ve güncel zorluklarını kapsamlı bir şekilde incelemek ve bunların kişiselleştirilmiş tedavinin geleceğindeki potansiyel rolünü vurgulamaktır.

Anahtar Kelimeler

Biyouyumluluk , Drug delivery , Nanostructured boron

Nanostructured Boron Compounds for Biomedical Applications: Drug Delivery, Imaging, and Cancer Therapy

Öz

Nanostructured boron compounds have arisen as multifunctional materials with considerable potential in biological applications, especially in drug administration, imaging, and cancer treatment. Their distinctive physicochemical characteristics, such as elevated surface area, adjustable shape, chemical stability, and biocompatibility, render them appropriate for the development of improved nanocarriers and therapeutic medicines. Diverse synthesis methodologies, encompassing top-down and bottom-up procedures, permit meticulous regulation of size, shape, and functioning. These compounds exhibit effective functionality in targeted drug delivery, contrast enhancement for multimodal imaging, and tumor-selective therapies, including boron neutron capture therapy (BNCT). Furthermore, their capacity to amalgamate several therapeutic and diagnostic activities within a singular platform renders them exemplary candidates for combination and theranostic strategies. Notwithstanding existing hurdles concerning toxicity, regulatory frameworks, and scalable production, ongoing interdisciplinary research is anticipated to facilitate their clinical translation and enhance their application in customized medicine. This review aims to comprehensively examine the properties, synthesis methods, biomedical applications, and current challenges of nanostructured boron compounds, highlighting their potential role in the future of personalized therapy.

Anahtar Kelimeler

Nanostructured boron; , Drug delivery , Biocompatibility

Kaynakça

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