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Electrocardiographic Changes in Occupational Exposure to Arsenic

Yıl 2021, Cilt 7, Sayı 1, 40 - 44, 31.03.2021

Öz

Introduction: Arsenic (As) and its poisonous effects, toxic nature and carcinogenic effects are well-documented. As an environmental toxicant, As widely appears in nature in both its organic and inorganic form. As an occupational toxicant, As is shown to be linked to an increased risk in many cardiovascular diseases including hypertension, ischemic heart disease, peripheral arterial disease (also known as Blackfoot disease), and carotid atherosclerosis. QT prolongation is a frequently seen effect of as poisoning and a dispersion of QT is implicated in the genesis of ventricular arrhythmias as well as a direct predictor of cardiovascular mortality. Materials and Methods: A total of 207 metal-mine workers, who were admitted to the Ankara Occupational Diseases Hospital for a routine annual follow up, were enrolled in the study. A control group was composed of 207 healthy individuals who were screened for arrhythmias, hypertension and obstructive coronary artery disease. Patients being treated with a medication that could affect the QT interval and patients with the conditions, were excluded from the study. Statistical differences were analysed by performing independent sample t-tests. Results: Our study showed a significant difference in the QT max between healthy individuals and the subjects with high occupational As exposure (P=0.039). QT dispersion and an As level in the hair samples, also showed a significant difference between the study groups (p=0.002 and p=0.001 respectively). Discussion: Possible occupational exposure to As may cause cardiac arrhythmias and sudden cardiac death. Further studies are needed to document the increased cardiac risk in populations with environmental and occupational exposure.

Kaynakça

  • Referance1 Chen, C. J., Chiou, H. Y., Chiang, M. H., Lin, L. J., & Tai, T. Y. (1996). Dose-response relationship between ischemic heart disease mortality and long-term arsenic exposure. Arteriosclerosis, thrombosis, and vascular biology, 16(4), 504-510. https://doi.org/10.1161/01.ATV.16.4.504
  • Referance2 Wang, C. H., Hsiao, C. K., Chen, C. L., Hsu, L. I., Chiou, H. Y., Chen, S. Y., ... & Chen, C. J. (2007). A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases. Toxicology and applied pharmacology, 222(3), 315-326. https://doi.org/10.1016/j.taap.2006.12.022
  • Referance3 Ohnishi, K., Yoshida, H., Shigeno, K., Nakamura, S., Fujisawa, S., Naito, K., ... & Sugiyama, S. (2000). Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Annals of Internal Medicine, 133(11), 881-885. https://doi.org/10.7326/0003-4819-133-11-200012050-00012

Yıl 2021, Cilt 7, Sayı 1, 40 - 44, 31.03.2021

Öz

Kaynakça

  • Referance1 Chen, C. J., Chiou, H. Y., Chiang, M. H., Lin, L. J., & Tai, T. Y. (1996). Dose-response relationship between ischemic heart disease mortality and long-term arsenic exposure. Arteriosclerosis, thrombosis, and vascular biology, 16(4), 504-510. https://doi.org/10.1161/01.ATV.16.4.504
  • Referance2 Wang, C. H., Hsiao, C. K., Chen, C. L., Hsu, L. I., Chiou, H. Y., Chen, S. Y., ... & Chen, C. J. (2007). A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases. Toxicology and applied pharmacology, 222(3), 315-326. https://doi.org/10.1016/j.taap.2006.12.022
  • Referance3 Ohnishi, K., Yoshida, H., Shigeno, K., Nakamura, S., Fujisawa, S., Naito, K., ... & Sugiyama, S. (2000). Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Annals of Internal Medicine, 133(11), 881-885. https://doi.org/10.7326/0003-4819-133-11-200012050-00012

Ayrıntılar

Birincil Dil İngilizce
Konular Tıp
Bölüm Case Report
Yazarlar

Gökhan KESKİN (Sorumlu Yazar)
AMASYA UNIVERSITY
0000-0002-1695-5624
Türkiye


Erdinç PELİT Bu kişi benim
Didim State Hospital, Aydın. Cardiology Polyclinic
0000-0003-0668-3511
Türkiye


Abdülkadir ÇAKMAK Bu kişi benim
Amasya University Education and Research Hospital, Department of Cardiology
0000-0001-7427-3368
Türkiye


Arslan SAY
AMASYA UNIVERSITY
Türkiye


Yılmaz ÖZBAY Bu kişi benim
AMASYA UNIVERSITY
0000-0002-3643-7170
Türkiye

Destekleyen Kurum Destekleyen kurum yoktur.
Yayımlanma Tarihi 31 Mart 2021
Başvuru Tarihi 18 Kasım 2020
Kabul Tarihi 31 Mart 2021
Yayınlandığı Sayı Yıl 2021, Cilt 7, Sayı 1

Kaynak Göster

Bibtex @araştırma makalesi { ijcesen827863, journal = {International Journal of Computational and Experimental Science and Engineering}, issn = {}, eissn = {2149-9144}, address = {}, publisher = {İskender AKKURT}, year = {2021}, volume = {7}, pages = {40 - 44}, doi = {}, title = {Electrocardiographic Changes in Occupational Exposure to Arsenic}, key = {cite}, author = {Keskin, Gökhan and Pelit, Erdinç and Çakmak, Abdülkadir and Say, Arslan and Özbay, Yılmaz} }
APA Keskin, G. , Pelit, E. , Çakmak, A. , Say, A. & Özbay, Y. (2021). Electrocardiographic Changes in Occupational Exposure to Arsenic . International Journal of Computational and Experimental Science and Engineering , 7 (1) , 40-44 . Retrieved from https://dergipark.org.tr/tr/pub/ijcesen/issue/57886/827863
MLA Keskin, G. , Pelit, E. , Çakmak, A. , Say, A. , Özbay, Y. "Electrocardiographic Changes in Occupational Exposure to Arsenic" . International Journal of Computational and Experimental Science and Engineering 7 (2021 ): 40-44 <https://dergipark.org.tr/tr/pub/ijcesen/issue/57886/827863>
Chicago Keskin, G. , Pelit, E. , Çakmak, A. , Say, A. , Özbay, Y. "Electrocardiographic Changes in Occupational Exposure to Arsenic". International Journal of Computational and Experimental Science and Engineering 7 (2021 ): 40-44
RIS TY - JOUR T1 - Electrocardiographic Changes in Occupational Exposure to Arsenic AU - Gökhan Keskin , Erdinç Pelit , Abdülkadir Çakmak , Arslan Say , Yılmaz Özbay Y1 - 2021 PY - 2021 N1 - DO - T2 - International Journal of Computational and Experimental Science and Engineering JF - Journal JO - JOR SP - 40 EP - 44 VL - 7 IS - 1 SN - -2149-9144 M3 - UR - Y2 - 2021 ER -
EndNote %0 International Journal of Computational and Experimental Science and Engineering Electrocardiographic Changes in Occupational Exposure to Arsenic %A Gökhan Keskin , Erdinç Pelit , Abdülkadir Çakmak , Arslan Say , Yılmaz Özbay %T Electrocardiographic Changes in Occupational Exposure to Arsenic %D 2021 %J International Journal of Computational and Experimental Science and Engineering %P -2149-9144 %V 7 %N 1 %R %U
ISNAD Keskin, Gökhan , Pelit, Erdinç , Çakmak, Abdülkadir , Say, Arslan , Özbay, Yılmaz . "Electrocardiographic Changes in Occupational Exposure to Arsenic". International Journal of Computational and Experimental Science and Engineering 7 / 1 (Mart 2021): 40-44 .
AMA Keskin G. , Pelit E. , Çakmak A. , Say A. , Özbay Y. Electrocardiographic Changes in Occupational Exposure to Arsenic. IJCESEN. 2021; 7(1): 40-44.
Vancouver Keskin G. , Pelit E. , Çakmak A. , Say A. , Özbay Y. Electrocardiographic Changes in Occupational Exposure to Arsenic. International Journal of Computational and Experimental Science and Engineering. 2021; 7(1): 40-44.
IEEE G. Keskin , E. Pelit , A. Çakmak , A. Say ve Y. Özbay , "Electrocardiographic Changes in Occupational Exposure to Arsenic", International Journal of Computational and Experimental Science and Engineering, c. 7, sayı. 1, ss. 40-44, Mar. 2021

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