Analysis of prognostic markers and survival data of patients with mantle cell lymphoma: A single-center experience

Öz

Aim: The aim of this study was to share our experience about long-term outcome of patients with mantle cell lymphoma (MCL) who admitted to our center by analysing the disease characteristics, response to treatment and survival data.
Materials and Methods: A retrospective study was conducted on newly-diagnosed MCL patients who admitted at our centre between 2010 and 2017. Demographic and disease characeristics and response to treatment data were analyzed. Survival analysis was performed to determine the factors affecting survival.
Results: A total of 19 MCL patients were included in the study. 10 (52.6%) of the patients were male and 9 (47.4%) were female and the mean age was 65.47±10.72 (years). The median follow-up duration was 29.4 [2.5-84.0] months. While 8 patients (42.1%) had complete response (CR1) and 5 patients (26.3%) had partial response (PR), 6 patients (31.5%) were accepted as unresponsive to first line chemotherapy. Overall survival (OS) was 44.2 [5.9-282.5] months. Lactate dehydrogenase (LDH) level at the time of diagnosis and the achievement of CR1 were demonstrated to have significant effect on survival (Odds Ratio (OR): 1.007, 95%CI: 1.002-1.013; p=0.011 vs OR: 0.990, 95%CI: 0.000-0.312; p=0.009).
Conclusion: The results of this study demonstrated that higher LDH levels at the time of diagnosis and insufficient response to first-line treatment have negative effect on survival. Patients with those should be monitored more closely and their treatment regimens should be more intensive and individualized by adding new agents.

Anahtar Kelimeler

• lymphoma,mantle,response,survival

Mantle hücreli lenfoma hastalarında prognostik belirteçler ve sağkalım analizi: Tek merkez deneyimi

Öz

Amaç: Bu çalışmanın amacı, merkezimize başvuran mantle hücreli lenfoma (MHL) hastalarının hastalık özelliklerini, tedaviye yanıt oranlarını ve sağkalım verilerini inceleyerek, uzun vadeli sonuçlar hakkında deneyimimizi paylaşmaktır.
Gereç ve Yöntemler: Merkezimizde 2010-2017 yılları arasında yeni tanısı konulan MHL hastalarının verileri retrospektif olarak incelendi. Demografik ve hastalık verileri incelenerek hastalık özellikleri ve tedaviye yanıt oranları analiz edildi. Sağkalım analizleri yapılarak sağkalımı etkileyen faktörler araştırıldı.
Bulgular: Toplam 19 MHL tanısı alan hasta çalışmaya dahil edildi. Hastaların 10'u (%52.6) erkek, 9'u (%47.4) kadın ve ortalama yaş 65.47±10.72 (yıl) idi. Medyan takip süresi 29.4 [2.5-84.0] ay idi. 1. basamak kemoterapiye 8 hasta (%42.1) tam yanıt (TY1) ve 5 hasta (%26.3) kısmi yanıt (KY) verirken, 6 hasta (%31.5) ise yanıtsız kabul edildi. Genel sağkalım (OS) 44.2 [5.9-82.5] ay olarak bulundu. Hastaların tanı anındaki laktat dehidrogenaz (LDH) düzeylerinin ve birinci basamak kemoterapiye TY1 elde etme durumunun sağkalım sürelerine anlamlı etkisi olduğu görüldü (Odds Ratio (OR):1.007, %95CI:1.002-1.013; p=0.011 vs OR:0.990, %95CI:0.000-0.312; p=0.009).
Sonuç: Bu çalışmanın sonuçları; tanı anında yüksek LDH düzeylerinin ve ilk sıra tedaviye yetersiz yanıtın sağkalıma olumsuz etkisi olduğunu göstermektedir. Bu özelliklere sahip hastalar daha yakın takip edilmeli ve tedavi rejimleri daha yoğun ve yeni ajanlar eklenerek bireyselleştirilmelidir.

Anahtar Kelimeler

• lenfoma,mantle,yanıt,sağkalım

Kaynakça

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