Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2020, Cilt: 6 Sayı: 2, 10 - 18, 14.06.2020

Öz

Kaynakça

  • Adlercreutz H, Mazur W: Phyto-oestrogens and Western diseases. Ann Med 29:95–120, 1997.
  • Adlercreutz H: Phyto-oestrogens and cancer. Lancet Oncol 3:364–373, 2002.
  • Albertazzi, P., Pansini, F., Bonaccorsi, G., Zanotti, L., Forini, E., and De Aloysio, D., The effect of dietary soy supplementation on hot flashes, Obstet. Gynecol., 91:6-11, 1998.
  • Alekel DL, Peterson CT: Isoflavone-rich soy protein isolate exerts significant bone-sparing in the lumbar spine of perimenopausal women. Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease. Washington, DC, October 1999.
  • Alekel, D.L., St. Germain, A., Peterson, C.T., Hanson, K. B., Stewart, J.W., and Toda, T., Isoflavone-rich soy protein isolate exerts significant bone-sparing in the lumbar spine of perimenopausal women, Am. J. Clin. Nutr., 72(3):844-52, 2000.
  • Anderson JJB, Thomsen K, Christiansen C: High protein meals, insular hormones and urinary calcium excretion in human subjects, in Christiansen C, Johansen JS, Riis BJ (eds): Osteoporosis 1987. Viborg, Denmark, Norhaven A/S, pp 240-245, 1987.
  • Anderson, J.J.B. and Garner, S., C., The effect of phytoestrogens on bone, Nutr. Res., 17: 1617-1632, 1997.
  • Anderson, J.J.B., Ambrose, W.W., and Garner, S.C., Biphasic effect of genistein on bone tissue in the ovariectomized, lactating rat model, PSEBM, 217: 345-350, 1998.
  • Arjmandi, B.H., Alekel, L., Hollis, B. W., Amin, D., Stacewicz-Sapuntzakis, M., Guo, P., and Kukreja, S.C., Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis, J., Nutr., 126: 161-167, 1996.
  • Arjmandi, B.H., Birnbaum, R.S., Juma, S., Barengolts, E., and Kukreja, S.C., The synthetic phytoestrogen, ipriflavone, and estrogen prevent bone loss by different mechanisms, Calcif. Tissue Int., 66: 61-65, 2000.
  • Barsotti G, Navelesi R, Giampietro 0, et al: Effects of a vegetarian, supplemental diet on renal function, proteinuria, and glucose metabolism in patients with ‘overt’ diabetic nephropathy and renal insufficiency. Contrib Nephrol65:87-94, 1988.
  • Blair, H.C., Jordan, S.E., Peterson, T.G., and Barnes, S., Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats, J. Cell Biochem., 61: 629-637, 1996.
  • Brandi, M.L., Flavonoids: biochemical effects and therapeutic applications, Bone Miner., 19: S3-S64, 1992. Breslau NA, Brinkley L, Hill KD, et al: Relationship of animal protein-rich diet to kidney stone formation and calcium metabolism. J Clin Endocrinol Metab 66:140-146, 1988.
  • Cassidy A: Physiological effects of phyto-oestrogens in relation to cancer and other human health risks. Proc Nutr Sot 55:399-417,1996.
  • Chan AYM, Cheng MLL, Keil LC, et al: Functional response of healthy and diseased glomemli to a large protein-rich meal. J Clin Invest 81:245-254,1988.
  • Cheng, S.L., Zhang, S.F., Nelson, T.L., Warlow, P.M., and Civitelli, R., Stimulation of human osteoblast differentiation and function by ipriflavone and its metabolites, Calcif. Tissue Int. 55: 356-362, 1994.
  • Civitelli, R., In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics, Calcif. Tissue Int., 61: S12-14, 1997.
  • Coward L, Barnes NC, Setchell KDR, et al: Genistein, daidzein, and their J3-glycoside conjugates: Antitumor isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 41:1961-1967, 1993.
  • Coward L, Smith M, Kirk M, et al: Chemical modification of isoflavones in soyfoods during cooking and processing. Am J Clin Nutr 68: 1486S-1491S, 1998.
  • D’amico G, Gentile MG: Influence of diet on lipid abnormalities in human renal disease. Am J Kidney Dis 22:151-157,1993.
  • Dalais, F.S., Rice, G.E., Wahlqvist, M.L., Grehan, M., Murkies, A.L., Medley G., Ayton, R., and Strauss, B.J.G., Effects of dietary phytoestrogens in postmenopausal women. Climacteric, 1: 124-129, 1998.
  • Fanti, P., Monier-Faugere, M.C., Geng, Z., Schmidt, J., Morris, P.E., Cohen, D., and Malluche, H.H., The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats, Osteoporosis Int., 8: 274-281, 1998.
  • Gallagher, J.C., Rafferty, K., Haynatzka, V., and Wilson, W., The effect of soy protein on bone metabolism, presented at Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Washington, D.C., Abst., p.18, 1999.
  • Gao, Y.H. and Yamaguchi, M., Inhibitory effect of genistein on osteoclast-like cell formation in mouse marrow cultures, Biochem. Pharmacol., 58: 767-772, 1999. Hughes, D.E., Dai, A., Tiffee, J.C., Li, H.H., Mundy, G.R., and Boyce, B.F., Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta, Nat. Med.., 2: 1132-1136, 1996.
  • Ishida, H., Uesugi, T., Hirai, K., Toda, T., Nukaya, H., Yokotsuka, K., and Tsuji, K., Preventive effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficient diet, Biol. Pharm. Bull., 21: 62-66, 1998. Ishimi, Y., Miyaura, C., Ohmura, M., Onoe, Y., Sato, T., Uchiyama, Y., Ito, M., Wang, X., Suda, T., and Ikegami, S., Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency, Endocrinology, 140: 1893-1900, 1999.
  • Juturu V, Hsheih G, Kri-Etherton PM: Soy consumption and nutrient intakes of American adults based on the CSFII data base 1994-1996. Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease. Washington, DC, October 1999.
  • Kalu, D. N., Masoro, E.J., Yu, B. P., Hardin, R.R., and Hollis, B. W., Modulation of age-related hyperparathyroidism and senile bone loss in Fischer rats by soy protein and food restriction, Endocrinology, 122: 1847-1854, 1988.
  • Kim, H., Peterson, T.G., and Barnes, S., Mechanisms of action of the soy isoflavone genistein emerging role for its effect via transforming growth factor B signalling pathways. Am. J. Clin. Nutr. 68: 1418S-1425S, 1998.
  • Kontessis P, Jones SL, Dodds R, et alz Renal metabolic and hormonal responses to ingestion of animal and vegetable proteins. Kidney Int 38:136-144, 1990.
  • Lampe JW: Isoflavonoid and lignan phytoestrogens as dietary biomarkers. J Nutr 133:956S–964S, 2003.
  • Magee RJ, Rowland IR: Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br J Nutr 91:513–531, 2004.
  • Markiewicz L, Garey J, Adlercreutz H, et al: In vitro bioassays ofnon-steroidal phytoestrogens. J Steroid Biochem Mel Bid 45:399-405, 1993.
  • Mayr U, Butsch A, Schneider S: Validation of two in Vito test systems for estrogenic activities with zearalenone, phytoestrogens and cereal extracts. Toxicology 74:135-149, 1992.
  • Messina M, Kucuk O, Lampe JW: An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels. J AOAC Int 89:1121–1134, 2006.
  • Messina MJ, Persky V, Setchell KD, et al: Soy intake and cancer risk: A review of the in vitro and in viva data. Nutr Cancer 21:113-131, 1994.
  • Murkies, A. L., Lombard, C., Strauss, B.J.G., Wilcox, G., and Morton, M.S., Dietary flour supplementation decreases post-menopausal hot flashes: effect of soy and wheat, Maturitas,21,189-195, 1995.
  • Murphy PA, Song T, Buseman G, et al: Isoflavones in retail and institutional soy foods. J Agric Food Chem 47:2697-2704, 1999.
  • Nagata C, Takatsuka N, Kurisu Y, et al: Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. J Nutr 128:209-213, 1998.
  • Nakamura H, Takasawa M, Kasahara S, et al: Effects of acute protein loads on different sources on renal function of patients with diabetic nephropathy. TohokuJ Exp Med 159:153- 162,1989.
  • Ohta, H., Komukai, S., Makita, K., Masuzawa, T., and Nozawa, S., Effects of 1 year ipriflavone treatment on lumbar bone mineral density and bone metabolic markers in postmenopausal women with bone mass, Horm. Res., 51: 178-183, 1999.
  • Pansini, F., Bonaccorsi, G., Albertaza, P., Costantino, D., Valerio, A., Negri, C., Ferrazzini, S., Bonocuore I., De Aloysio, D., Fontana, A., Pansini, N., and Molica, G., Soy phytoestrogens and bone, presented at North Amerikan Menopause Society Meetings, Abstr,n97.061, p.44, 1997.
  • Pecis M, de Azevedo M, Gross JL: Chicken and fish diet reduces glomular hyperfiitration in IDDM patients. Diabetes Care 17~665-672, 1994.
  • Petilli, M., Fiorelli, G., Benvenuti, S., Frediani, U., Gori, F., and Brandi, M.L., Interactions between ipriflavone and the estrogen receptor, Calcif. Tissue Int., 56: 160-165, 1995.
  • Potter, S.M., Baum, J.A., Teng, H., Stillman, R.J., Shay, N.F., and Erdman, J.W., Jr., Soy protein and isoflavones : their effects on blood lipids and bone density in postmenopausal women, Am. J. Clin. Nutr., 68: 1375S-1379S, 1998.
  • Reinli K, Block G: Phytoestrogen content of food.-A compendium of literature values. Nutr Cancer 26:123-148, 1996.
  • Scheiber, M.D., Liu, J.H., Subbiah, M.T.R., Rebar, R.W., and Setchell, K.D.R., Dietary soy isoflavones favorably influence lipids and bone turnover in healthy postmenopausal women, presented at Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Washington, D.C., Abstr., pp. 18-19, 1999.
  • Stephan, E. B., and Dziak, R., Effects of genistein, tyrphostin, and pertussis toxin on EGF- induced mitogenesis in primary culture and clonal osteoblastic cells, Calsif. Tissue Int., 54. 409-413, 1994.
  • Valente, M., Bufalino, L., Castiglione, G.N., Angelo, R.D., Mancuso, A., Galoppi, P., and Zichella, L., Effects of 1 year treatment with ipriflavone on bone in postmenopausal women with low bone mass, Calcif. Tissue Int., 54: 377-380, 1994.
  • Washburn, S., Burke, G., Morgan, T., and Anthony, M., Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women, Menopause, 6: 7- 11, 1999.
  • Williams, J.P., Jordan, S.E., Barnes, S., and Blair, H.C., Tyrosine kinase inhibitor effects on avian osteoclastic acid transport, Am. J. Clin. Nutr., 68: 1369S-1374S, 1998.
  • Wong, W.W., Effects of soy isoflavones on blood lipids, blood pressure, and biochemical markers of bone metabolism in postmenopausal women, presented at Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Washington, D.C., Absr., pp. 35-36, 1999.
  • Yamaguchi, M. and Gao, Y.H., Inhibitory effect of genistein on bone resorption in tissue culture, Biochem. Pharmacol., 55: 71-76, 1998.
  • Yoon, H.K., Chen, K., Baylink, D. J., and Lau, K.H., Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation, Calcif. Tissue Int., 63: 243-249, 1998.

EFFECTS OF SOY PROTEIN AND SOYBEAN ISOFLAVONES ON BONE HEALTH

Yıl 2020, Cilt: 6 Sayı: 2, 10 - 18, 14.06.2020

Öz

Soybeans and soyfoods are for practical purposes, the only nutritionally relevant dietary sources of isoflavones. Soybean isoflavones are
structurally similar to estrogen, bind to estrogen receptors, and exhibit weak estrogenic activity. Soyfoods and soybean constituents have come
under investigation for their role in chronic disease prevention, especially for heart disease and cancer. Two factors, in particular, provided
the basis for initial speculation that soy might contribute to bone health. These are the estrogenic properties of soybean isoflavones and the
effectiveness of the synthetic isoflavone, ipriflavone, in reducing bone loss in perimenopausal and postmenopausal women. In addition, several
human studies have shown that soy protein, when substituted for animal protein, decreases calcium excretion. This review will focus on some
of the clinical researches relevant to the effects of both soy protein and soybean isoflavones on bone health.

Kaynakça

  • Adlercreutz H, Mazur W: Phyto-oestrogens and Western diseases. Ann Med 29:95–120, 1997.
  • Adlercreutz H: Phyto-oestrogens and cancer. Lancet Oncol 3:364–373, 2002.
  • Albertazzi, P., Pansini, F., Bonaccorsi, G., Zanotti, L., Forini, E., and De Aloysio, D., The effect of dietary soy supplementation on hot flashes, Obstet. Gynecol., 91:6-11, 1998.
  • Alekel DL, Peterson CT: Isoflavone-rich soy protein isolate exerts significant bone-sparing in the lumbar spine of perimenopausal women. Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease. Washington, DC, October 1999.
  • Alekel, D.L., St. Germain, A., Peterson, C.T., Hanson, K. B., Stewart, J.W., and Toda, T., Isoflavone-rich soy protein isolate exerts significant bone-sparing in the lumbar spine of perimenopausal women, Am. J. Clin. Nutr., 72(3):844-52, 2000.
  • Anderson JJB, Thomsen K, Christiansen C: High protein meals, insular hormones and urinary calcium excretion in human subjects, in Christiansen C, Johansen JS, Riis BJ (eds): Osteoporosis 1987. Viborg, Denmark, Norhaven A/S, pp 240-245, 1987.
  • Anderson, J.J.B. and Garner, S., C., The effect of phytoestrogens on bone, Nutr. Res., 17: 1617-1632, 1997.
  • Anderson, J.J.B., Ambrose, W.W., and Garner, S.C., Biphasic effect of genistein on bone tissue in the ovariectomized, lactating rat model, PSEBM, 217: 345-350, 1998.
  • Arjmandi, B.H., Alekel, L., Hollis, B. W., Amin, D., Stacewicz-Sapuntzakis, M., Guo, P., and Kukreja, S.C., Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis, J., Nutr., 126: 161-167, 1996.
  • Arjmandi, B.H., Birnbaum, R.S., Juma, S., Barengolts, E., and Kukreja, S.C., The synthetic phytoestrogen, ipriflavone, and estrogen prevent bone loss by different mechanisms, Calcif. Tissue Int., 66: 61-65, 2000.
  • Barsotti G, Navelesi R, Giampietro 0, et al: Effects of a vegetarian, supplemental diet on renal function, proteinuria, and glucose metabolism in patients with ‘overt’ diabetic nephropathy and renal insufficiency. Contrib Nephrol65:87-94, 1988.
  • Blair, H.C., Jordan, S.E., Peterson, T.G., and Barnes, S., Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats, J. Cell Biochem., 61: 629-637, 1996.
  • Brandi, M.L., Flavonoids: biochemical effects and therapeutic applications, Bone Miner., 19: S3-S64, 1992. Breslau NA, Brinkley L, Hill KD, et al: Relationship of animal protein-rich diet to kidney stone formation and calcium metabolism. J Clin Endocrinol Metab 66:140-146, 1988.
  • Cassidy A: Physiological effects of phyto-oestrogens in relation to cancer and other human health risks. Proc Nutr Sot 55:399-417,1996.
  • Chan AYM, Cheng MLL, Keil LC, et al: Functional response of healthy and diseased glomemli to a large protein-rich meal. J Clin Invest 81:245-254,1988.
  • Cheng, S.L., Zhang, S.F., Nelson, T.L., Warlow, P.M., and Civitelli, R., Stimulation of human osteoblast differentiation and function by ipriflavone and its metabolites, Calcif. Tissue Int. 55: 356-362, 1994.
  • Civitelli, R., In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics, Calcif. Tissue Int., 61: S12-14, 1997.
  • Coward L, Barnes NC, Setchell KDR, et al: Genistein, daidzein, and their J3-glycoside conjugates: Antitumor isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 41:1961-1967, 1993.
  • Coward L, Smith M, Kirk M, et al: Chemical modification of isoflavones in soyfoods during cooking and processing. Am J Clin Nutr 68: 1486S-1491S, 1998.
  • D’amico G, Gentile MG: Influence of diet on lipid abnormalities in human renal disease. Am J Kidney Dis 22:151-157,1993.
  • Dalais, F.S., Rice, G.E., Wahlqvist, M.L., Grehan, M., Murkies, A.L., Medley G., Ayton, R., and Strauss, B.J.G., Effects of dietary phytoestrogens in postmenopausal women. Climacteric, 1: 124-129, 1998.
  • Fanti, P., Monier-Faugere, M.C., Geng, Z., Schmidt, J., Morris, P.E., Cohen, D., and Malluche, H.H., The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats, Osteoporosis Int., 8: 274-281, 1998.
  • Gallagher, J.C., Rafferty, K., Haynatzka, V., and Wilson, W., The effect of soy protein on bone metabolism, presented at Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Washington, D.C., Abst., p.18, 1999.
  • Gao, Y.H. and Yamaguchi, M., Inhibitory effect of genistein on osteoclast-like cell formation in mouse marrow cultures, Biochem. Pharmacol., 58: 767-772, 1999. Hughes, D.E., Dai, A., Tiffee, J.C., Li, H.H., Mundy, G.R., and Boyce, B.F., Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta, Nat. Med.., 2: 1132-1136, 1996.
  • Ishida, H., Uesugi, T., Hirai, K., Toda, T., Nukaya, H., Yokotsuka, K., and Tsuji, K., Preventive effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficient diet, Biol. Pharm. Bull., 21: 62-66, 1998. Ishimi, Y., Miyaura, C., Ohmura, M., Onoe, Y., Sato, T., Uchiyama, Y., Ito, M., Wang, X., Suda, T., and Ikegami, S., Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency, Endocrinology, 140: 1893-1900, 1999.
  • Juturu V, Hsheih G, Kri-Etherton PM: Soy consumption and nutrient intakes of American adults based on the CSFII data base 1994-1996. Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease. Washington, DC, October 1999.
  • Kalu, D. N., Masoro, E.J., Yu, B. P., Hardin, R.R., and Hollis, B. W., Modulation of age-related hyperparathyroidism and senile bone loss in Fischer rats by soy protein and food restriction, Endocrinology, 122: 1847-1854, 1988.
  • Kim, H., Peterson, T.G., and Barnes, S., Mechanisms of action of the soy isoflavone genistein emerging role for its effect via transforming growth factor B signalling pathways. Am. J. Clin. Nutr. 68: 1418S-1425S, 1998.
  • Kontessis P, Jones SL, Dodds R, et alz Renal metabolic and hormonal responses to ingestion of animal and vegetable proteins. Kidney Int 38:136-144, 1990.
  • Lampe JW: Isoflavonoid and lignan phytoestrogens as dietary biomarkers. J Nutr 133:956S–964S, 2003.
  • Magee RJ, Rowland IR: Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br J Nutr 91:513–531, 2004.
  • Markiewicz L, Garey J, Adlercreutz H, et al: In vitro bioassays ofnon-steroidal phytoestrogens. J Steroid Biochem Mel Bid 45:399-405, 1993.
  • Mayr U, Butsch A, Schneider S: Validation of two in Vito test systems for estrogenic activities with zearalenone, phytoestrogens and cereal extracts. Toxicology 74:135-149, 1992.
  • Messina M, Kucuk O, Lampe JW: An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels. J AOAC Int 89:1121–1134, 2006.
  • Messina MJ, Persky V, Setchell KD, et al: Soy intake and cancer risk: A review of the in vitro and in viva data. Nutr Cancer 21:113-131, 1994.
  • Murkies, A. L., Lombard, C., Strauss, B.J.G., Wilcox, G., and Morton, M.S., Dietary flour supplementation decreases post-menopausal hot flashes: effect of soy and wheat, Maturitas,21,189-195, 1995.
  • Murphy PA, Song T, Buseman G, et al: Isoflavones in retail and institutional soy foods. J Agric Food Chem 47:2697-2704, 1999.
  • Nagata C, Takatsuka N, Kurisu Y, et al: Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. J Nutr 128:209-213, 1998.
  • Nakamura H, Takasawa M, Kasahara S, et al: Effects of acute protein loads on different sources on renal function of patients with diabetic nephropathy. TohokuJ Exp Med 159:153- 162,1989.
  • Ohta, H., Komukai, S., Makita, K., Masuzawa, T., and Nozawa, S., Effects of 1 year ipriflavone treatment on lumbar bone mineral density and bone metabolic markers in postmenopausal women with bone mass, Horm. Res., 51: 178-183, 1999.
  • Pansini, F., Bonaccorsi, G., Albertaza, P., Costantino, D., Valerio, A., Negri, C., Ferrazzini, S., Bonocuore I., De Aloysio, D., Fontana, A., Pansini, N., and Molica, G., Soy phytoestrogens and bone, presented at North Amerikan Menopause Society Meetings, Abstr,n97.061, p.44, 1997.
  • Pecis M, de Azevedo M, Gross JL: Chicken and fish diet reduces glomular hyperfiitration in IDDM patients. Diabetes Care 17~665-672, 1994.
  • Petilli, M., Fiorelli, G., Benvenuti, S., Frediani, U., Gori, F., and Brandi, M.L., Interactions between ipriflavone and the estrogen receptor, Calcif. Tissue Int., 56: 160-165, 1995.
  • Potter, S.M., Baum, J.A., Teng, H., Stillman, R.J., Shay, N.F., and Erdman, J.W., Jr., Soy protein and isoflavones : their effects on blood lipids and bone density in postmenopausal women, Am. J. Clin. Nutr., 68: 1375S-1379S, 1998.
  • Reinli K, Block G: Phytoestrogen content of food.-A compendium of literature values. Nutr Cancer 26:123-148, 1996.
  • Scheiber, M.D., Liu, J.H., Subbiah, M.T.R., Rebar, R.W., and Setchell, K.D.R., Dietary soy isoflavones favorably influence lipids and bone turnover in healthy postmenopausal women, presented at Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Washington, D.C., Abstr., pp. 18-19, 1999.
  • Stephan, E. B., and Dziak, R., Effects of genistein, tyrphostin, and pertussis toxin on EGF- induced mitogenesis in primary culture and clonal osteoblastic cells, Calsif. Tissue Int., 54. 409-413, 1994.
  • Valente, M., Bufalino, L., Castiglione, G.N., Angelo, R.D., Mancuso, A., Galoppi, P., and Zichella, L., Effects of 1 year treatment with ipriflavone on bone in postmenopausal women with low bone mass, Calcif. Tissue Int., 54: 377-380, 1994.
  • Washburn, S., Burke, G., Morgan, T., and Anthony, M., Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women, Menopause, 6: 7- 11, 1999.
  • Williams, J.P., Jordan, S.E., Barnes, S., and Blair, H.C., Tyrosine kinase inhibitor effects on avian osteoclastic acid transport, Am. J. Clin. Nutr., 68: 1369S-1374S, 1998.
  • Wong, W.W., Effects of soy isoflavones on blood lipids, blood pressure, and biochemical markers of bone metabolism in postmenopausal women, presented at Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Washington, D.C., Absr., pp. 35-36, 1999.
  • Yamaguchi, M. and Gao, Y.H., Inhibitory effect of genistein on bone resorption in tissue culture, Biochem. Pharmacol., 55: 71-76, 1998.
  • Yoon, H.K., Chen, K., Baylink, D. J., and Lau, K.H., Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation, Calcif. Tissue Int., 63: 243-249, 1998.
Toplam 53 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Ülkü Demirci Bu kişi benim

Yayımlanma Tarihi 14 Haziran 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 6 Sayı: 2

Kaynak Göster

APA Demirci, Ü. (2020). EFFECTS OF SOY PROTEIN AND SOYBEAN ISOFLAVONES ON BONE HEALTH. Sanitas Magisterium, 6(2), 10-18.
AMA Demirci Ü. EFFECTS OF SOY PROTEIN AND SOYBEAN ISOFLAVONES ON BONE HEALTH. Sanitas magisterium. Haziran 2020;6(2):10-18.
Chicago Demirci, Ülkü. “EFFECTS OF SOY PROTEIN AND SOYBEAN ISOFLAVONES ON BONE HEALTH”. Sanitas Magisterium 6, sy. 2 (Haziran 2020): 10-18.
EndNote Demirci Ü (01 Haziran 2020) EFFECTS OF SOY PROTEIN AND SOYBEAN ISOFLAVONES ON BONE HEALTH. Sanitas Magisterium 6 2 10–18.
IEEE Ü. Demirci, “EFFECTS OF SOY PROTEIN AND SOYBEAN ISOFLAVONES ON BONE HEALTH”, Sanitas magisterium, c. 6, sy. 2, ss. 10–18, 2020.
ISNAD Demirci, Ülkü. “EFFECTS OF SOY PROTEIN AND SOYBEAN ISOFLAVONES ON BONE HEALTH”. Sanitas Magisterium 6/2 (Haziran 2020), 10-18.
JAMA Demirci Ü. EFFECTS OF SOY PROTEIN AND SOYBEAN ISOFLAVONES ON BONE HEALTH. Sanitas magisterium. 2020;6:10–18.
MLA Demirci, Ülkü. “EFFECTS OF SOY PROTEIN AND SOYBEAN ISOFLAVONES ON BONE HEALTH”. Sanitas Magisterium, c. 6, sy. 2, 2020, ss. 10-18.
Vancouver Demirci Ü. EFFECTS OF SOY PROTEIN AND SOYBEAN ISOFLAVONES ON BONE HEALTH. Sanitas magisterium. 2020;6(2):10-8.

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