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Cultural and Medicinal Uses of Ferula foetida: From Kyrgyzstan to Global Perspectives

Yıl 2025, Cilt: 8 Sayı: 2, 153 - 162, 15.08.2025
https://doi.org/10.38001/ijlsb.1483697

Öz

Ferula foetida holds significant botanical, medicinal, and economic importance in Kyrgyzstan. This literature review provides an in-depth exploration of medicinal Ferula, focusing on its chemical contents, traditional uses, pharmacological activities, and future considerations within the context of Kyrgyzstan. The morphological diversity of Ferula foetida is examined alongside their distribution patterns across the varied landscapes of Kyrgyzstan. Chemical constituents, including secondary metabolites, essential oils, and bioactive compounds, are elucidated, highlighting their potential therapeutic significance. Traditional uses of Ferula foetida in Kyrgyzstan encompass a wide range of applications in folk medicine. Pharmacological activities, such as antioxidant, anti-inflammatory, and antimicrobial properties, are discussed based on scientific evidence and traditional knowledge. Additionally, future considerations address the sustainable utilization and conservation of Ferula foetida. In Kyrgyzstan, particularly in the face of increasing export demands. Excessive exploitation of resources forces agriculturists and biologists in our country to urgently search for ways to balance the exploitation of natural populations, protect reserves, and cultivate valuable plants. The burgeoning export market underscores the economic value of Ferula foetida, prompting the need for responsible harvesting practices and conservation efforts to safeguard this valuable botanical resource for future generations.

Kaynakça

  • 1. Caretta, M.A., A. Mukherji, M. Arfanuzzaman, R.A. Betts, A. Gelfan, Y. Hirabayashi, T.K. Lissner, J. Liu, E. Lopez Gunn, R. Morgan, S. Mwanga, and S. Supratid, 2022: Water. In: Climate Change 2022: Impacts, Adaptation and Vulnerability. Contribution of Working Group II to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change [H.-O. Pörtner, D.C. Roberts, M. Tignor, E.S. Poloczanska, K. Mintenbeck, A. Alegría, M. Craig, S. Langsdorf, S. Löschke, V. Möller, A. Okem, B. Rama (eds.)]. Cambridge University Press, Cambridge, UK and New York, NY, USA, pp. 551–712, doi:10.1017/9781009325844.006
  • 2. Usupbaev A.K., Milko D.A.: «Zelenoe zoloto Kyrgyzstana», ili k oprosu o strategicheskom potenciale poleznyh dikorastushih rastenii // Vestnik mezhdunarodnogo medicinskogo universiteta, Bishkek, 2022, № 4 С. 27-36. (Усупбаев А.К., Милько Д. А. «Зелёное золото Кыргызстана», или к опросу о стратегическом потенциале полезных дикорастущих растений // Вестник международного медицинского университета, Бишкек, 2022, № 4 С. 27-36)
  • 3. Baylea, A., & Kaya, Y. (2023): Chemical Characteristics and Biotechnological Potentials of Mumio. Manas Journal of Agriculture Veterinary and Life Sciences, 13(2), 187-195. https://doi.org/10.53518/mjavl.1327332
  • 4. Taşeva, G., Sabırkulova, T., Kıdıralıyeva, B., Omurzakova, N., et al. (2022): Kırgızistan çeltik üretimine genel bir bakış. Frontiers in Life Sciences and Related Technologies, 3(2), 86-94. https://doi.org/10.51753/flsrt.1122101
  • 5. FAO (2022): Comprehensive analysis of the disaster risk reduction system for the agricultural sector in Kyrgyzstan. Budapest, https://doi.org/10.4060/cb8418en
  • 6. Narbayep, Marat and Pavlova, Vera. The Aral Sea, Central Asian Countries and Climate Change in the 21st Century. United Nations ESCAP, IDD, April 2022. Bangkok.
  • 7. Tojibaev KS, Karimov FI, Hoshimov HR, Gulomov R, Lazkov GA, Jang C-G, Gil H-Y, Jang J-E, Batoshov AR, Iskandarov A, Choi HJ (2023): Important plant areas (IPAs) in the Fergana Valley (Central Asia): The Bozbu-Too-Ungortepa massif. Nature Conservation 51: 13-70. https://doi.org/10.3897/natureconservation.51.94477
  • 8. Камелин Р. В. Ботанико-географические районы Киргизии / Р. В. Камелин // Зонтичные Киргизии. – Москва : KMK Scientific Press Ltd, 2002. – С. 1-18. (Kamelin R. V. Botaniko-geograficheskiye rayony Kirgizii / R. V. Kamelin // Zontichnyye Kirgizii. – Moskva : KMK Scientific Press Ltd, 2002. — С. 1–18.)
  • 9. Shalpykov K. T., (2015): Lekarstvennyye i aromaticheskiye rasteniya v Kyrgyzstane. Ohrana i ustoychivoye ispol'zovaniye resursov lekarstvennykh rasteniy // Sbornik materialov ostayetsya mezhdunar. nauch. prakt. konf. — Bishkek, 2015. — S. 122–127. (Шалпыков К. Т., (2015): Лекарственные и ароматические растения в Кыргызстане. Охрана и устойчивое использование ресурсов лекарственных растений // Сборник материалов третьей междунар. науч. практ. конф. —Бишкек, 2015. — С. 122–127)
  • 10. Sagyndykova, M.S. & Imanbayeva, Akjunis & Belozerov, I.F.. (2018): Polymorphism of morphological characteristics of Ferula foetida (Bunge) regel in the natural populations of the Mangyshlak peninsula. Journal of Pharmaceutical Sciences and Research. 10. 2084-2091.
  • 11. Kareparamban, J.A. & Nikam, P.H. & Jadhav, A.P. & Kadam, V.J.. (2012): Ferula foetida" hing": A review. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 3. 775-786.
  • 12. Salehi M., Naghavi M.R., Bahmankar M.: A review of Ferula species: Biochemical characteristics, pharmaceutical and industrial applications, and suggestions for biotechnologists. Ind. Crops Prod. 2019;139:111511. doi: 10.1016/j.indcrop.2019.111511.
  • 13. Znati M., Hichem B.J., Cazaux S., Bouajila J.: Chemical composition, biological and cytotoxic activities of plant extracts and compounds isolated from Ferula lutea. Molecules. 2014;19:2733–2747. doi: 10.3390/molecules19032733.
  • 14. Bahetjan, Y.; Muhaxi, M.; Pang, K.; Kizaibek, M.; Tang, H.; Sefidkon, F.; Yang, X.: Chemistry, Bioactivity, and Prediction of the Quality Marker (Q-Marker) of Ferula
  • 15. Lin, J.R.; Jin, M.; Wu, C.M.: Advances in studies on chemical constituents and pharmacological effects of Ferula. Strait Pharm. J. 2014, 26, 1–3.
  • 16. Liu, Q.X.; Hui, H.: The chemical constituents of volatile oil from Ferula L. in China and its taxonomical significance. J. Plant Resour. Environ. 1997, 6, 27–32.
  • 17. Ying, F.H.; Qian, X.Q.; Liu, B.R.: Progress in the study of the anti-tumor mechanism of action of ferulic acid. Mod. J. Integr. Tradit. Chin. West. Med. 2010, 19, 4238–4240.
  • 18. Suzuki, K.; Okasaka, M.; Kashiwada, Y.; Takaishi, Y.; Honda, G.; Ito, M.; Takeda, Y.; Kodzhimatov, O.K.; Ashurmetov, O.; Sekiya, M.; et al.: Sesquiterpene Lactones from the Roots of Ferula Waria and Their Cytotoxic Activity. J. Nat. Prod. 2007, 70, 1915–1918.
  • 19. Wang, S.; Sheng, P.; Yao, L.; Du, B.J.: GC-MS fingerprint of in vitro anti-gastric cancer active parts from roots of Uygur medicine Ferula ferulaeoides. Chin. Tradit. Herb. Drugs 2015, 46, 2874–2879.
  • 20. Mahendra P, Bisht S.: Ferula asafoetida: Traditional uses and pharmacological activity. Pharmacogn Rev. 2012 Jul;6(12):141-6. doi: 10.4103/0973-7847.99948. PMID: 23055640; PMCID: PMC3459456.
  • 21. Divya, K.; Ramalakshmi, K.; Murthy, P.S.; Jagan Mohan Rao, L.: Volatile oils from Ferula asafoetida varieties and their antimicrobial activity. LWT Food Sci. Technol. 2014, 59, 774–779.
  • 22. Javanshir, S.; Soukhtanloo, M.; Jalili-Nik, M.; Yazdi, A.J.; Amiri, M.S.; Ghorbani, A.: Evaluation Potential Antidiabetic Effects of Ferula latisecta in Streptozotocin-Induced Diabetic Rats. J. Pharmacopunct. 2020, 23, 158–164.
  • 23. Lee, C.L.; Chiang, L.C.; Cheng, L.H.; Chuang, L.C.; Mohamed, H.A.E.-R.; Chang, F.R.; Wu, Y.C.: Influenza A (H1N1) Antiviral and Cytotoxic Agents from Ferula assa-foetida. J. Nat. Prod. 2009, 72, 1568–1572.
  • 24. Duke JA, Ayensu ES: Medicinal plants of China. Vol. 1. Algonac, Michigan: Reference Publications Inc; 1985. pp. 52–361.
  • 25. Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Eslami B, Dehpour AA.: Antioxidant and antihaemolytic activities of Ferula foetida regel (Umbelliferae). Eur Rev Med Pharmacol Sci. 2011 Feb;15(2):157-64. PMID: 21434482.
  • 26. Ghasemi Z, Rezaee R, Aslani MR, Boskabady MH.: Anti-inflammatory, anti-oxidant, and immunomodulatory activities of the genus Ferula and their constituents: A review.
  • 27. Kamboj, V.P. (1988): A review of Indian medicinal plants with interceptive activity. Indian J. Med. Res., 3: 336-355
  • 28. Nazari ZE, Iranshahi M.: Biologically active sesquiterpene coumarins from Ferula species. Phytother Res. 2011 Mar;25(3):315-23. doi: 10.1002/ptr.3311. Epub 2010 Oct 28. PMID: 21031633.
  • 29. Bagheri SM, Hedesh ST, Mirjalili A, Dashti-R MH.: Evaluation of anti-inflammatory and some possible mechanisms of antinociceptive effect of Ferula assafoetida oleo gum resin. Evid Based Complement Alternat Med. 2016; 21:271–276.
  • 30. Bagheri SM, Yadegari M, Zare-Mohazabiye F, Momeni-Asl H, Mirjalili A, Anvari M, et al.: Effect of Ferula assa foetida oleogum-resin on gastric ulcer in indomethacin-ulcerated rats. J Curr Res Sci Med 2018; 4:42-6
  • 31. Vilas A. Kamble & Sahadeo D. Patil (2008): Spice-Derived Essential Oils: Effective Antifungal and Possible Therapeutic Agents, Journal of Herbs, Spices & Medicinal Plants, 14:3-4, 129-143, DOI: 10.1080/10496470802598677
  • 32. G. Kavoosi, V. Rowshan.: Chemical composition, antioxidant and antimicrobial activities of essential oil obtained from Ferula asafoetida oleo-gum-resin: effect of collection time. Food Chem, 138 (2013), pp. 2180-2187
  • 33. Oüzek G, Schepetkin IA, Utegenova GA, Kirpotina LN, Andrei SR, Oüzek T, et al.: Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils. J Leukoc Biol. 2017;101:1361–1371.
  • 34. Safi R, Rodriguez F, Hilal G, Diab-Assaf M, Diab Y, El-Sabban M, et al.: Hemisynthesis, antitumoral effect, and molecular docking studies of ferutinin and its analogues. Chem Bio & Drug Design. 2016;87:382–397.
  • 35. Barthomeuf C, Lim S, Iranshahi M, Chollet P.: Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis. Phytomedicine. 2008;15:103–111.
  • 36. Deniz G, Laloglu E, Koc K, Geyikoglu F.: Hepatoprotective potential of Ferula communis extract for carbon tetrachloride induced hepatotoxicity and oxidative damage in rats. Biotech Histochem. 2019;94:334–340.
  • 37. G.S. Tayeboon, F. Tavakoli, S. Hassani, M. Khanavi, O. Sabzevari, S.N. Ostad.: Effects of Cymbopogon citratus and Ferula asafoetida extracts on glutamate-induced neurotoxicity. In vitro Cell Dev Biol-Anim, 49 (2013), pp. 706-715
  • 38. R. Gundamaraju.: Evaluation of anti-helmintic activity of Ferula foetida “Hing- A natural Indian spice” aqueous extract. Asian Pac J Trop Dis, 3 (2013), pp. 189-191
  • 39. M. Fatehi, F. Farifteh, Z. Fatehi-Hassanabad.: Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. J Ethnopharmacol, 91 (2004), pp. 321-324
  • 40. Elghwaji W., El-Sayed A. M., El-Deeb K. S., ElSayed A. M. (2017): Chemical composition, antimicrobial and antitumor potentiality of essential oil of Ferula tingitana L. Apiaceae grow in Libya. Phcog. Mag. 13 (3), 446–451. 10.4103/pm.pm_323_15
  • 41. Heck AM, DeWitt BA, Lukes AL.: Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57:1221–7.
  • 42. Aldayarov, N., Tulobaev, A., Salykov, R., Jumabekova, J., Kydyralieva, B., Omurzakova, N., Kurmanbekova, G., Imanberdieva, N., Usubaliev, B., Borkoev, B., Salieva, K., Salieva, Z., Omurzakov, T., & Chekirov, K. (2022). An ethnoveterinary study of wild medicinal plants used by the Kyrgyz farmers. Journal of Ethnopharmacology, 285, 114842. https://doi.org/10.1016/j.jep.2021.114842

Ferula foetida'nın Kültürel ve Tıbbi Kullanımları

Yıl 2025, Cilt: 8 Sayı: 2, 153 - 162, 15.08.2025
https://doi.org/10.38001/ijlsb.1483697

Öz

Ferula foetida Kırgızistan'da önemli botanik, tıbbi ve ekonomik öneme sahiptir. Bu literatür taraması, kimyasal içeriklerine, geleneksel kullanımlarına, farmakolojik aktivitelerine ve Kırgızistan bağlamında geleceğe yönelik düşüncelere odaklanarak tıbbi Ferula'nın derinlemesine bir incelemesini sunmaktadır. Ferula foetida'nın morfolojik çeşitliliği, Kırgızistan'ın çeşitli coğrafyalarındaki dağılım desenleriyle birlikte inceleniyor. İkincil metabolitler, uçucu yağlar ve biyoaktif bileşikler de dahil olmak üzere kimyasal bileşenler, potansiyel terapötik önemleri vurgulanarak açıklanmaktadır. Kırgızistan'da Ferula foetida'nın geleneksel kullanımları halk hekimliğinde geniş bir uygulama yelpazesini kapsamaktadır. Antioksidan, antiinflamatuar ve antimikrobiyal özellikler gibi farmakolojik aktiviteler bilimsel kanıtlara ve geleneksel bilgilere dayanarak tartışılmaktadır. Ek olarak, gelecekteki değerlendirmeler Ferula foetida'nın sürdürülebilir kullanımı ve korunmasına yöneliktir. Kırgızistan'da özellikle artan ihracat talepleri karşısında. Kaynakların aşırı kullanımı, ülkemizdeki tarımcıları ve biyologları acilen doğal popülasyonların sömürülmesini dengelemenin, rezervleri korumanın ve değerli bitkiler yetiştirmenin yollarını aramaya zorluyor. Büyüyen ihracat pazarı, Ferula foetida'nın ekonomik değerinin altını çiziyor ve bu değerli botanik kaynağı gelecek nesiller için korumak için sorumlu hasat uygulamalarına ve koruma çabalarına duyulan ihtiyacı ortaya çıkarıyor.

Kaynakça

  • 1. Caretta, M.A., A. Mukherji, M. Arfanuzzaman, R.A. Betts, A. Gelfan, Y. Hirabayashi, T.K. Lissner, J. Liu, E. Lopez Gunn, R. Morgan, S. Mwanga, and S. Supratid, 2022: Water. In: Climate Change 2022: Impacts, Adaptation and Vulnerability. Contribution of Working Group II to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change [H.-O. Pörtner, D.C. Roberts, M. Tignor, E.S. Poloczanska, K. Mintenbeck, A. Alegría, M. Craig, S. Langsdorf, S. Löschke, V. Möller, A. Okem, B. Rama (eds.)]. Cambridge University Press, Cambridge, UK and New York, NY, USA, pp. 551–712, doi:10.1017/9781009325844.006
  • 2. Usupbaev A.K., Milko D.A.: «Zelenoe zoloto Kyrgyzstana», ili k oprosu o strategicheskom potenciale poleznyh dikorastushih rastenii // Vestnik mezhdunarodnogo medicinskogo universiteta, Bishkek, 2022, № 4 С. 27-36. (Усупбаев А.К., Милько Д. А. «Зелёное золото Кыргызстана», или к опросу о стратегическом потенциале полезных дикорастущих растений // Вестник международного медицинского университета, Бишкек, 2022, № 4 С. 27-36)
  • 3. Baylea, A., & Kaya, Y. (2023): Chemical Characteristics and Biotechnological Potentials of Mumio. Manas Journal of Agriculture Veterinary and Life Sciences, 13(2), 187-195. https://doi.org/10.53518/mjavl.1327332
  • 4. Taşeva, G., Sabırkulova, T., Kıdıralıyeva, B., Omurzakova, N., et al. (2022): Kırgızistan çeltik üretimine genel bir bakış. Frontiers in Life Sciences and Related Technologies, 3(2), 86-94. https://doi.org/10.51753/flsrt.1122101
  • 5. FAO (2022): Comprehensive analysis of the disaster risk reduction system for the agricultural sector in Kyrgyzstan. Budapest, https://doi.org/10.4060/cb8418en
  • 6. Narbayep, Marat and Pavlova, Vera. The Aral Sea, Central Asian Countries and Climate Change in the 21st Century. United Nations ESCAP, IDD, April 2022. Bangkok.
  • 7. Tojibaev KS, Karimov FI, Hoshimov HR, Gulomov R, Lazkov GA, Jang C-G, Gil H-Y, Jang J-E, Batoshov AR, Iskandarov A, Choi HJ (2023): Important plant areas (IPAs) in the Fergana Valley (Central Asia): The Bozbu-Too-Ungortepa massif. Nature Conservation 51: 13-70. https://doi.org/10.3897/natureconservation.51.94477
  • 8. Камелин Р. В. Ботанико-географические районы Киргизии / Р. В. Камелин // Зонтичные Киргизии. – Москва : KMK Scientific Press Ltd, 2002. – С. 1-18. (Kamelin R. V. Botaniko-geograficheskiye rayony Kirgizii / R. V. Kamelin // Zontichnyye Kirgizii. – Moskva : KMK Scientific Press Ltd, 2002. — С. 1–18.)
  • 9. Shalpykov K. T., (2015): Lekarstvennyye i aromaticheskiye rasteniya v Kyrgyzstane. Ohrana i ustoychivoye ispol'zovaniye resursov lekarstvennykh rasteniy // Sbornik materialov ostayetsya mezhdunar. nauch. prakt. konf. — Bishkek, 2015. — S. 122–127. (Шалпыков К. Т., (2015): Лекарственные и ароматические растения в Кыргызстане. Охрана и устойчивое использование ресурсов лекарственных растений // Сборник материалов третьей междунар. науч. практ. конф. —Бишкек, 2015. — С. 122–127)
  • 10. Sagyndykova, M.S. & Imanbayeva, Akjunis & Belozerov, I.F.. (2018): Polymorphism of morphological characteristics of Ferula foetida (Bunge) regel in the natural populations of the Mangyshlak peninsula. Journal of Pharmaceutical Sciences and Research. 10. 2084-2091.
  • 11. Kareparamban, J.A. & Nikam, P.H. & Jadhav, A.P. & Kadam, V.J.. (2012): Ferula foetida" hing": A review. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 3. 775-786.
  • 12. Salehi M., Naghavi M.R., Bahmankar M.: A review of Ferula species: Biochemical characteristics, pharmaceutical and industrial applications, and suggestions for biotechnologists. Ind. Crops Prod. 2019;139:111511. doi: 10.1016/j.indcrop.2019.111511.
  • 13. Znati M., Hichem B.J., Cazaux S., Bouajila J.: Chemical composition, biological and cytotoxic activities of plant extracts and compounds isolated from Ferula lutea. Molecules. 2014;19:2733–2747. doi: 10.3390/molecules19032733.
  • 14. Bahetjan, Y.; Muhaxi, M.; Pang, K.; Kizaibek, M.; Tang, H.; Sefidkon, F.; Yang, X.: Chemistry, Bioactivity, and Prediction of the Quality Marker (Q-Marker) of Ferula
  • 15. Lin, J.R.; Jin, M.; Wu, C.M.: Advances in studies on chemical constituents and pharmacological effects of Ferula. Strait Pharm. J. 2014, 26, 1–3.
  • 16. Liu, Q.X.; Hui, H.: The chemical constituents of volatile oil from Ferula L. in China and its taxonomical significance. J. Plant Resour. Environ. 1997, 6, 27–32.
  • 17. Ying, F.H.; Qian, X.Q.; Liu, B.R.: Progress in the study of the anti-tumor mechanism of action of ferulic acid. Mod. J. Integr. Tradit. Chin. West. Med. 2010, 19, 4238–4240.
  • 18. Suzuki, K.; Okasaka, M.; Kashiwada, Y.; Takaishi, Y.; Honda, G.; Ito, M.; Takeda, Y.; Kodzhimatov, O.K.; Ashurmetov, O.; Sekiya, M.; et al.: Sesquiterpene Lactones from the Roots of Ferula Waria and Their Cytotoxic Activity. J. Nat. Prod. 2007, 70, 1915–1918.
  • 19. Wang, S.; Sheng, P.; Yao, L.; Du, B.J.: GC-MS fingerprint of in vitro anti-gastric cancer active parts from roots of Uygur medicine Ferula ferulaeoides. Chin. Tradit. Herb. Drugs 2015, 46, 2874–2879.
  • 20. Mahendra P, Bisht S.: Ferula asafoetida: Traditional uses and pharmacological activity. Pharmacogn Rev. 2012 Jul;6(12):141-6. doi: 10.4103/0973-7847.99948. PMID: 23055640; PMCID: PMC3459456.
  • 21. Divya, K.; Ramalakshmi, K.; Murthy, P.S.; Jagan Mohan Rao, L.: Volatile oils from Ferula asafoetida varieties and their antimicrobial activity. LWT Food Sci. Technol. 2014, 59, 774–779.
  • 22. Javanshir, S.; Soukhtanloo, M.; Jalili-Nik, M.; Yazdi, A.J.; Amiri, M.S.; Ghorbani, A.: Evaluation Potential Antidiabetic Effects of Ferula latisecta in Streptozotocin-Induced Diabetic Rats. J. Pharmacopunct. 2020, 23, 158–164.
  • 23. Lee, C.L.; Chiang, L.C.; Cheng, L.H.; Chuang, L.C.; Mohamed, H.A.E.-R.; Chang, F.R.; Wu, Y.C.: Influenza A (H1N1) Antiviral and Cytotoxic Agents from Ferula assa-foetida. J. Nat. Prod. 2009, 72, 1568–1572.
  • 24. Duke JA, Ayensu ES: Medicinal plants of China. Vol. 1. Algonac, Michigan: Reference Publications Inc; 1985. pp. 52–361.
  • 25. Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Eslami B, Dehpour AA.: Antioxidant and antihaemolytic activities of Ferula foetida regel (Umbelliferae). Eur Rev Med Pharmacol Sci. 2011 Feb;15(2):157-64. PMID: 21434482.
  • 26. Ghasemi Z, Rezaee R, Aslani MR, Boskabady MH.: Anti-inflammatory, anti-oxidant, and immunomodulatory activities of the genus Ferula and their constituents: A review.
  • 27. Kamboj, V.P. (1988): A review of Indian medicinal plants with interceptive activity. Indian J. Med. Res., 3: 336-355
  • 28. Nazari ZE, Iranshahi M.: Biologically active sesquiterpene coumarins from Ferula species. Phytother Res. 2011 Mar;25(3):315-23. doi: 10.1002/ptr.3311. Epub 2010 Oct 28. PMID: 21031633.
  • 29. Bagheri SM, Hedesh ST, Mirjalili A, Dashti-R MH.: Evaluation of anti-inflammatory and some possible mechanisms of antinociceptive effect of Ferula assafoetida oleo gum resin. Evid Based Complement Alternat Med. 2016; 21:271–276.
  • 30. Bagheri SM, Yadegari M, Zare-Mohazabiye F, Momeni-Asl H, Mirjalili A, Anvari M, et al.: Effect of Ferula assa foetida oleogum-resin on gastric ulcer in indomethacin-ulcerated rats. J Curr Res Sci Med 2018; 4:42-6
  • 31. Vilas A. Kamble & Sahadeo D. Patil (2008): Spice-Derived Essential Oils: Effective Antifungal and Possible Therapeutic Agents, Journal of Herbs, Spices & Medicinal Plants, 14:3-4, 129-143, DOI: 10.1080/10496470802598677
  • 32. G. Kavoosi, V. Rowshan.: Chemical composition, antioxidant and antimicrobial activities of essential oil obtained from Ferula asafoetida oleo-gum-resin: effect of collection time. Food Chem, 138 (2013), pp. 2180-2187
  • 33. Oüzek G, Schepetkin IA, Utegenova GA, Kirpotina LN, Andrei SR, Oüzek T, et al.: Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils. J Leukoc Biol. 2017;101:1361–1371.
  • 34. Safi R, Rodriguez F, Hilal G, Diab-Assaf M, Diab Y, El-Sabban M, et al.: Hemisynthesis, antitumoral effect, and molecular docking studies of ferutinin and its analogues. Chem Bio & Drug Design. 2016;87:382–397.
  • 35. Barthomeuf C, Lim S, Iranshahi M, Chollet P.: Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis. Phytomedicine. 2008;15:103–111.
  • 36. Deniz G, Laloglu E, Koc K, Geyikoglu F.: Hepatoprotective potential of Ferula communis extract for carbon tetrachloride induced hepatotoxicity and oxidative damage in rats. Biotech Histochem. 2019;94:334–340.
  • 37. G.S. Tayeboon, F. Tavakoli, S. Hassani, M. Khanavi, O. Sabzevari, S.N. Ostad.: Effects of Cymbopogon citratus and Ferula asafoetida extracts on glutamate-induced neurotoxicity. In vitro Cell Dev Biol-Anim, 49 (2013), pp. 706-715
  • 38. R. Gundamaraju.: Evaluation of anti-helmintic activity of Ferula foetida “Hing- A natural Indian spice” aqueous extract. Asian Pac J Trop Dis, 3 (2013), pp. 189-191
  • 39. M. Fatehi, F. Farifteh, Z. Fatehi-Hassanabad.: Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. J Ethnopharmacol, 91 (2004), pp. 321-324
  • 40. Elghwaji W., El-Sayed A. M., El-Deeb K. S., ElSayed A. M. (2017): Chemical composition, antimicrobial and antitumor potentiality of essential oil of Ferula tingitana L. Apiaceae grow in Libya. Phcog. Mag. 13 (3), 446–451. 10.4103/pm.pm_323_15
  • 41. Heck AM, DeWitt BA, Lukes AL.: Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57:1221–7.
  • 42. Aldayarov, N., Tulobaev, A., Salykov, R., Jumabekova, J., Kydyralieva, B., Omurzakova, N., Kurmanbekova, G., Imanberdieva, N., Usubaliev, B., Borkoev, B., Salieva, K., Salieva, Z., Omurzakov, T., & Chekirov, K. (2022). An ethnoveterinary study of wild medicinal plants used by the Kyrgyz farmers. Journal of Ethnopharmacology, 285, 114842. https://doi.org/10.1016/j.jep.2021.114842
Toplam 42 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bitki Biyoteknolojisi
Bölüm Derleme
Yazarlar

Aizhan Murzakanova 0009-0002-1158-6820

Gönderilme Tarihi 14 Mayıs 2024
Kabul Tarihi 19 Haziran 2024
Erken Görünüm Tarihi 16 Ağustos 2025
Yayımlanma Tarihi 15 Ağustos 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 8 Sayı: 2

Kaynak Göster

EndNote Murzakanova A (01 Ağustos 2025) Cultural and Medicinal Uses of Ferula foetida: From Kyrgyzstan to Global Perspectives. International Journal of Life Sciences and Biotechnology 8 2 153–162.


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