in vitro Study of Antidiabetic Effect of Abrus precatorius Methanol Leaves Extract against Glucose Absorption

Yıl 2020, , 117 - 126, 15.08.2020

Hafedh Al-moalemi , Wahid Altowayti Siti Pauliena Mohd Bohari

https://doi.org/10.38001/ijlsb.701093

Cited By: 1

Öz

Diabetes mellitus is a common chronic systemic disorder characterised by hyperglycaemia as a standard feature. A traditional plant known as Abrus precatorius (AP) has been used for the treatment of type II diabetes mellitus in Malaysia. The potential of the 80% methanolic extract of A. precatorius leaves has been tested in vitro for its α-glucosidase inhibition and its glucose diffusion activity. It was observed that the extraction of A. precatorius leaves exhibit a high α-glucosidase inhibition at the concentrations of 25 and 50 mg/mL (65.4% and 84.6%), respectively, but low inhibition at the concentration of 6.25 to 12.5 mg/mL (25% and 28.2%) when compared to control. Meanwhile, the methanolic extract of A. precatorius slightly affected the glucose diffusion at the concentration of 50 mg/mL (9.5%) within 24 h compared to the control group. These results indicated that the methanolic extract of A. precatorius leaves is capable of inhibiting α-glucosidase activity, besides halting glucose diffusion activity by delaying the glucose absorption in the gut.

Anahtar Kelimeler

Abrus precatorius, Diabetes mellitus, Acarbose, Alpha-glucosidase, Glucose diffusion

Destekleyen Kurum

Universiti Teknologi Malaysia

Proje Numarası

Q.J130000.3554.07G36

Teşekkür

The authors thank Universiti Teknologi Malaysia for the financial support under the Research University Grant (Q.J130000.3554.07G36).

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