Mesoporous silica nanoparticles, methods of preparation and use of bone tissue engineering

Öz

Biomaterials are a large group of vitally important materials with many different inorganic and organic types. Biocomposites are produced by using materials such as polymer, metal, and ceramics. Bone tissue engineering deals with materials that can mimic the real bone structure found in the body. These materials used in the human body must be capable of many aspects such as their mechanical strength related to the area where they are used, as well as their properties such as biocompatible, biodegradable, and non-toxic. If the material is intended to treat the bone structure, it should be biodegradable, but it should be resistant to degradation if intended to be used for a long time. With the advance in technology, nanoparticles have become appealing in bone tissue engineering due to their many unique properties. In recent years, mesoporous silica nanoparticles (MSNs) have been prominent biomaterials in the medical field due to their properties such as alterable size structure, large pore volume, and surface area. This study aims to give information about the biomedical properties, synthesis methods, and importance of MSNs with unique properties in bone tissue engineering applications. This study is compiled by examining many studies in the literature.

Anahtar Kelimeler

• Silica nanoparticles
• mesoporous
• tissue engineering
• biomaterials

Kaynakça

1. Bhavsar, D., V Patel and K. Sawant, Systematic investigation of in vitro and in vivo safety, toxicity and degradation of mesoporous silica nanoparticles synthesized using commercial sodium silicate. Microporous and Mesoporous Materials, 2019. 284: p. 343–352.
2. Jia, Y., et al., Regeneration of large bone defects using mesoporous silica coated magnetic nanoparticles during distraction osteogenesis. Nanomedicine, Nanotechnology, Biology, and Medicine, 2019. 21: 102040.
3. Çetinkaya, S. and N. Kütük, Green Synthesis of Iron Oxide Nanoparticles Using Black Tea Extract and Investigation of Its Properties. Materials Focus, 2018. 7: p. 316-320.
4. Kütük, N. and S. Çetinkaya, Yeşil Sentez ile Nanomalzeme Üretiminin İncelenmesi ve Kullanım Alanları. 5. Uluslararası Mimarlık Mühendislik ve Tasarım Kongresi. 21-22 Aralık, 2019, İstanbul
5. Tsamesidis, I., et al.,Effect of ion doping in silica-based nanoparticles on the hemolytic and oxidative activity in contact with human erythrocytes. Chemico-Biological Interactions, 2020. 318: 108974.
6. Moreira, A., F., D.A. Dias and I., J. Correira, Stimuli-responsive mesoporous silica nanoparticles for cancer therapy, A review. Microporous and Mesoporous Materials, 2016. 236: p. 141-157.
7. Perry, C., C. An Overview of Silica in Biology, Its Chemistry and Recent Technological Advances, Biosilica in Evolution. Morphogenesis, and Nanobiotechnology, 2009.p. 295-313.
8. Carcouet C., C., M., C. et al., Nucleation and Growth of Monodisperse Silica Nanoparticles. Nano Letters, 2014. 14(3): p. 1433-1438.

9. Hwang, J., J., H. Lee and J., Chun, Facile approach for the synthesis of spherical mesoporous silica nanoparticles from sodium silicate. Materials Letters, 2021, 283: 128765.
10. Mohanraj, R., et al., Decolourisation efficiency of immobilized silica nanoparticles synthesized by actinomycetes. Materials Today, Proceedings, 2020. In Press
11. Li Y., et al., In situ silica nanoparticles-reinforced biodegradable poly(citrate-siloxane)hybrid elastomers with multifunctional properties for simultaneous bioimagingand bone tissue regeneration. Applied Materials Today, 2017. 10: p.153-163.
12. Luo, Z., et al., Peptide-laden mesoporous silica nanoparticles with promotedbioactivity and osteo-differentiation ability for bone tissue engineering. Colloids and Surfaces B, Biointerfaces, 2015, 131: p. 73–82.
13. Pandey P. And M. Dahiya, A Brief Review On Inorganic Nanoparticles. Journal of Critical Reviews, 2016. 3(3): p. 18-26.
14. Xu, Z., et al.,Multifunctional silica nanoparticles as a promising theranostic platform for biomedical applications. Material Chemistry Frontiers, 2017.
15. Zhang, R., et al., How to design nanoporous silica nanoparticles in regulating drug delivery, Surface modification and porous control. Materials Science and Engineering B, 2021. 263: 114835.
16. Beck, G., R., et al., Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts, suppress bone-resorbing osteoclasts, and enhance bone mineral density in vivo. Nanomedicine, Nanotechnology, Biology, and Medicine, 2012. 8: p. 793–803.
17. Uyanıkgil E., Ö., Ç. and D., S. Salmanoğlu, Metalik nanopartiküllerin hedeflendirilmesi. Ege Tıp Dergisi, 2020. 59(1): p. 71-81.
18. Huang, R., et al., Mesoporous silica nanoparticles, facile surface functionalization and versatile biomedical applications in oncology. Acta Biomaterialia, 2020. 116: p. 1-15.
19. Ha, S., et al., Bioactive effects of silica nanoparticles on bone cells are size, surface, and composition dependent. Acta Biomaterialia, 2018. 82: p. 184-196.
20. Lee, D., et al., Injectable hydrogel composite containing modified gold nanoparticles, implication in bone tissue regeneration. International Journal of Nanomedicine, 2018. 13: p. 7019–7031.
21. Ross, R., D., L., E. Cole and R., K. Roeder, Relative binding affinity of carboxylate-, phosphonate-, and bisphosphonate-functionalized gold nanoparticles targeted to damaged bone tissue. Journal of Nanoparticle Research, 2012. 14: 1175.
22. Kumar, P., Nano-TiO2 Doped Chitosan Scaffold for the Bone Tissue Engineering Applications. International Journal of Biomaterials, 2018. 6576157.
23. El-Deeb, N., M., et al., Novel Trend in Colon Cancer Therapy Using Silver Nanoparticles Synthesized by Honey Bee. J Nanomed Nanotechnol, 2015. 6(2): 1000265.
24. Sankar, R., et al., Facile synthesis of Curcuma longa tuber powder engineered metal nanoparticles for bioimaging applications. Journal of Molecular Structure, 2017. 1129: p. 8-16.
25. Vimala, K., et al., Synergistic effect of chemo-photothermal for breast cancer therapy using folic acid (FA) modified zinc oxide nanosheet. Journal of Colloid and Interface Science, 2017. 488: p. 92–108.
26. Sadhukhan, P., et al., Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy. Materials Science & Engineering C, 2019. 100: p. 129–140.
27. Sahmani, S., et al., Effect of copper oxide nanoparticles on electrical conductivity and cell viability of calcium phosphate scaffolds with improved mechanical strength for bone tissue engineering. The European Physıcal Journal Plus, 2019. 134(7).
28. Gholamali, I., et al., Preparation and Characterization of Oxidized Starch/CuO Nanocomposite Hydrogels Applicable in a Drug Delivery System. Starch, 2018. 71, 3-4.
29. Ahmadian, Y., et al., Synthesis of polyvinyl alcohol/CuO nanocomposite hydrogel and its application as drug delivery agent. Polymer Bulletin, 2019. 76: p. 1967–1983.
30. Lin, W., et al., Toxicity of Cerium Oxide Nanoparticles in Human Lung Cancer Cells. International Journal of Toxicology, 2006. 25: p. 451–457.
31. Pesic, M., et al., Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity. Chemico-Biological Interactions, 2015. 232: p. 85–93.
32. Sack, M., et al., Combination of Conventional Chemotherapeutics with Redox-Active Cerium Oxide Nanoparticles-A Novel Aspect in Cancer Therapy. Small Molecule Therapeutics, 2014. 13(7): p. 1740-1749.
33. Nie, L., et al., Development of chitosan/gelatin hydrogels incorporation of biphasic calcium phosphate nanoparticles for bone tissue engineering. Journal of Biomaterials Science. Polymer Edition, 2019. 30(17): p. 1636-1657.
34. Ding Y., et al., Encapsulation of cisplatin in a pegylated calcium phosphate nanoparticle (CPNP) for enhanced cytotoxicity to cancerous cells. Journal of Colloid and Interface Science, 2017. 493: p. 181–189.
35. Zhao, J., et al., Calcium phosphate nanoneedle based gene delivery system for cancer genetic immunotherapy. Biomaterials, 2020. 250.
36. Xia, Y., et al., Magnetic field and nano-scaffolds with stem cells to enhance bone regeneration. Biometarials, 2018. 183: p. 151-170.
37. Huang, W. and I. Chu, Injectable polypeptide hydrogel/inorganic nanoparticle composites for bone tissue engineering. Plos One, 2019. 14(1): 0210285.
38. Pasqua, L., et al., Mesoporous silica-based hybrid materials for bonespecific drug delivery, Nanoscale Advances, 2019. 1: p. 3269–3278.
39. Kaliaraj, R., et al., A biomimetic mesoporous silica–polymer composite scaffold for bone tissue engineering. J Porous Mater, 2018. 25: p. 397–406.
40. Kempen, P., J., et al., Theranostic mesoporous silica nanoparticles biodegrade after pro-survival drug delivery and ultrasound/ magnetic resonance imaging of stem cells. Theranostics, 2015. 5: 631.
41. Dang, Y. and J. Guan, Nanoparticle-based drug delivery systems for cancer therapy. Smart Materials in Medicine, 2020. 1: p. 10–19.
42. Wang, Y., et al., Mesoporous silica nanoparticles in drug delivery and biomedical applications, Nanomedicine, Nanotechnology. Biology, and Medicine, 2015. 11: p. 313–327.
43. Martin, P., et al., MCM-41-based composite with enhanced stability for Cr(VI) removal from aqueous media. Solid State Sciences, 2020. 106: 106300.
44. Möller, K. and T. Bein, Talented Mesoporous Silica Nanoparticles. Chemistry of Materials, 2016, 29(1): p. 371-388.
45. Pajchel, L. and W. Kolodziejski, Synthesis and characterization of MCM-48/hydroxyapatite composites for drug delivery. Ibuprofen incorporation. location and release studies. Materials Science and Engineering C, 2018. 91: p. 734–742.
46. Prokowisz, M., et al., Surface-Activated Fibre-Like SBA-15 as Drug Carriers for Bone Diseases. AAPS PharmSciTech, 2019, 20(17).
47. Güçbilmez, Y., Production And Characterizatıon Of MCM-41 And MCM-48 Type Catalysts. Journal of Engineering and Architecture Faculty of Eskişehir Osmangazi University, 2010. XXIII(1): p. 63-81.
48. Timpe, N., et al., Nanoporous silica nanoparticles with spherical and anisotropic shape as fillers in dental composite materials. BioNanoMat, 2014. 15(3-4): p. 89–99.
49. Tang H., et al., Facile synthesis of pH sensitive polymer-coated mesoporous silica nanoparticles and their application in drug delivery. International Journal of Pharmaceutics, 2011. 421: p. 388– 396.
50. Wang, L., et al., Biofunctionalized Phospholipid-Capped Mesoporous Silica Nanoshuttles for Targeted Drug Delivery, Improved Water Suspensibility and Decreased Nonspecific Protein Binding. ACS Nano, 2010. 4(8): p. 4371-4379.
51. Lu, Z., et al., Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition. Bioactive Materials, 2020. 5: p. 1127–1137.
52. Martinez-Carmona, M., et al., Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment. Acta Biomaterialia, 2018. 65: p. 393–404.
53. He, Y., et al., Redox and pH dual-responsive biodegradable mesoporous silica nanoparticle as a potential drug carrier for synergistic cancer therapy. Ceramics International, 2020. 47(4): p. 4572-4578.
54. Zhou, X., et al., BMP‑2 Derived Peptide and Dexamethasone Incorporated Mesoporous Silica Nanoparticles for Enhanced Osteogenic Differentiation of Bone Mesenchymal Stem Cells. ACS Applied Materials and Interfaces, 2015. 7(29): p. 15777–15789.
55. Xu, H., et al., A facile route for rapid synthesis of hollow mesoporous silica nanoparticles as pH-responsive delivery carrier, Journal of Colloid and Interface Science, 2015. 451: p. 101–107.
56. Feng J., et al., The impact of ethanol and chlorobenzene in the structure regulation of dendritic mesoporous silica Nanoparticles. Microporous and Mesoporous Materials, 2020. 307: 110504.
57. Lu C., et al., Utilization of iron tailings to prepare high-surface area mesoporous silica materials. Science of the Total Environment, 2020. 736: 139483.
58. Yakin, F., E., M. Barisik and T. Sen, Pore Size and Porosity Dependent Zeta Potentials of Mesoporous Silica Nanoparticles. Journal of Physical Chemistry C, 2020. 124: p. 19579−19587.
59. Karaman E., Ş., et al., One-pot synthesis of pore-expanded hollow mesoporous silica particles. Materials Letters, 2015. 143: p. 140-143.
60. Qiu Q., et al., pH-triggered sustained drug release of multilayer encapsulation system with hollow mesoporous silica nanoparticles/chitosan/polyacrylic acid. Materials Letters, 2020. 260: 126907.
61. Yan, T., et al., Chitosan capped pH-responsive hollow mesoporous silica nanoparticles for targeted chemo-photo combination therapy. Carbohydrate Polymers, 2020. 231: 115706.
62. Nguyen T., N., T., et al., Surface PEGylation of hollow mesoporous silica nanoparticles via aminated Intermediate. Progress in Natural Science, Materials International, 2019. 29: p. 612–616.
63. Perez-Garnes M., et al., Engineering hollow mesoporous silica nanoparticles to increase cytotoxicity. Materials Science and Engineering C, 2020. 112: 110935.
64. Deng S., et al., A facile and controllable one-pot synthesis approach to amino-functionalized hollow silica nanoparticles with accessible ordered mesoporous shells. Chinese Chemical Letters, 2020.
65. Ways, T., M., M., et al., Silica Nanoparticles in Transmucosal Drug Delivery. Pharmaceutics, 2020. 12: 751.
66. Pang, X. And F. Tang, Morphological control of mesoporous materials using inexpensive silica sources. Microporous and Mesoporous Materials, 2005. 85: p. 1–6.
67. Ortega, E., et al., Improvement of mesoporous silica nanoparticles, A new approach in the administration of NSAIDS. Journal of Drug Delivery Science and Technology, 2020. 58: 101833.
68. Faaliyan, K., et al., Magnetite-silica nanoparticles with core-shell structure, single-step synthesis, characterization and magnetic behavior. Journal of Sol-Gel Science and Technology, 2018. 88: p. 609-617.
69. Lagarrigue, P., et al., Well-defined polyester-grafted silica nanoparticles for biomedical applications, Synthesis and quantitative characterization. Polymer, 2020. 211: 123048.
70. Castro, A., G., B., et al., Development of a PCL-silica nanoparticles composite membrane for Guided Bone Regeneration. Materials Science & Engineering C, 2018. 85: p. 154–161.
71. Kanniyappan, H., et al., Evaluating the inherent osteogenic and angiogenic potential of mesoporous silica nanoparticles to augment vascularized bone tissue formation. Microporous and Mesoporous Materials, 2021. 311: 110687.
72. Black, J., D., J. and B., J. Tadros, Bone structure, from cortical to calcium, Orthopaedics and Trauma, 2020. 34(3): p. 113-119.
73. Gao, C., et al., Bone biomaterials and interactions with stem cell. Bone Research, 2017. 5: 17059.
74. Atthapreyangkul, A., M., Hoffman and G. Pearce, Effect of geometrical structure variations on the viscoelastic and anisotropic behaviour of cortical bone using multi-scale finite element modelling. Journal of the Mechanical Behavior of Biomedical Materials, 2020. 113: 104153.
75. Erol, M., M., et al., Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering. Acta Biomaterialia, 2012. 8: 792–801.
76. Parwani, R., et al., Morphological and Mechanical Biomimetic Bone Structures. ACS Biomater. Sci. Eng., 2017. 3: p. 2761−2767.
77. Oyar, P., Osseointegrasyon Ve Kemik Rejenerasyonunda Kemik Doku Mühendisliğinin Yeri. Atatürk Üniv. Diş Hek. Fak. Derg. 2016. 15: p. 87-95.
78. Wittig, N., K., et al., Bone Biomineral Properties Vary across Human Osteonal Bone. ACS Nano, 2019. 13: p. 12949−12956.
79. Velasco, M., A., C., A. Narvaez-Tovar and D., A. Garzon-Alvarado, Design, Materials, and Mechanobiology of Biodegradable Scaffolds for Bone Tissue Engineering. BioMed Research International, 2015. 729076.
80. Stevens, M., M., Biomaterials for bone tissue engineering. Materials Today, 2008. 11(5): p. 18-25.
81. Amini, A., R., C., T. Laurencin and S., P. Nukavarapu, Bone Tissue Engineering, Recent Advances and Challenges. Crit Rev Biomed Eng., 2012. 40(5): p. 363–408.
82. Qiu, K., et al., Electrophoretic Deposition of Dexamethasone-loaded Mesoporous Silica Nanoparticles onto Poly(L-lactic acid)/Poly(#–caprolactone) Composite Scaffold for Bone Tissue Engineering. ACS Applied Materials Interfaces, 2016. 8(6): p. 4137-4148.
83. Zhu, W., et al., Injectable and assembled 3D solid structure for free-to-fixed shape in bone reconstruction. Applied Materials Today, 2020. 21: 100823.
84. Koons, K., L., M. Diba and A., G. Mikos, Materials design for bone- tissue engineering. Nature Review Materials, 2020. 5: p. 584-603.
85. Zhou, P., et al.,. Organic/Inorganic Composite Membranes Based on Poly(L‑lactic-coglycolic acid) and Mesoporous Silica for Effective Bone Tissue Engineering. ACS Appl. Mater. Interfaces, 2014. 6: p. 20895−20903.
86. Huri, Y., P., N. Hasırcı and V. Hasırcı, Kemik Doku Mühendisliği. Arşiv, 2010. 19: p. 206-219.
87. Qi, Q., et al., Mechanically robust and thermally insulating polyarylene ether nitrile with a bone-like structure. Materials and Design, 2020. 196: 109099.
88. Özkan, A., N. Şişik and U. Öztürk, Kompozit Malzemelerin Ağız, Yüz, Çene Cerrahisinde Kullanımı ve Malzeme Uygunluklarının Belirlenmesi. Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2016. 4: p. 227-242.
89. Wang, Y., H. Pan and X. Chen, The Preparation of Hollow Mesoporous Bioglass Nanoparticles With Excellent Drug Delivery Capacity for Bone Tissue Regeneration. Frontiers in Chemistry, 2019. 7: 283.
90. Price, C., T., K., J. Koval and J., R. Langford, Silicon, A Review of Its Potential Role in the Prevention and Treatment of Postmenopausal Osteoporosis. International Journal of Endocrinology, 2013. 2013: 316783.
91. Oudadesse, H., et al., MAS-NMR studies of geopolymers heat-treated for applications in biomaterials field. J Mater Sci, 2007. 42: p. 3092–3098.