A Review of Approaches in Steviol Glycosides Synthesis

Yıl 2019, Cilt: 2 Sayı: 3, 145 - 157, 28.12.2019

Nurul Hidayah Samsulrizal Zarina Zainuddin Abdul Latif Noh Tamil Chelvan Sundram

https://doi.org/10.38001/ijlsb.577338

Cited By: 5

Öz

Stevia
rebaudiana (Bertoni) is a commercially important plant
worldwide. The leaves of stevia contain steviol glycosides which are non-caloric
and high-potency sweeteners. They are suitable for substituting sucrose and
other artificial sweetening agents. Stevia also has many therapeutic properties
such as antidiabetic, anti-cariogenic, antimicrobial, anticancer and antioxidative.
Rebaudioside A and stevioside are the major glycosides produced in stevia
leaves. Development of new varieties of Stevia rebaudiana with a greater
content of rebaudioside A and decreased content of stevioside is the main concern.
This is due to rebaudioside A having a more desirable sweet flavour taste than
stevioside which possesses bitter aftertaste. In respect to that, many biotechnological
approaches are available for the industrial improvement and manipulation of steviol
glycosides content in stevia. Transcriptome profiling has emerged as a useful
tool to identify target genes involved in the steviol glycosides biosynthesis
pathway. Understanding the mechanism and biosynthesis pathway of these
compounds can help to improve the glycosides profile by up-regulating and
down-regulating desired genes. The aim of this paper is to describe the latest
development in the transcriptome profiling in stevia as well as to discuss the
methods used in this endeavour.

Anahtar Kelimeler

Stevia, Stevia rebaudiana, steviol glycoside, transcriptome

Destekleyen Kurum

International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia

Proje Numarası

RIGS17-022-0597

Teşekkür

We thank International Islamic University Malaysia (IIUM) Research Initiative Grant Scheme (RIGS17-022-0597) for supporting this work.

Kaynakça

• Ceunen, S., Werbrouck, S., & Geuns, J. M. Stimulation of steviol glycoside accumulation in Stevia rebaudiana by red LED light. Journal of plant physiology, 2012. 169(7), 749-752.
• Chen, J., Hou, K., Qin, P., Liu, H., Yi, B., Yang, W., & Wu, W. RNA-Seq for gene identification and transcript profiling of three Stevia rebaudiana genotypes. BMC genomics, 2014.15(1), 571.
• Gupta, P. Plant tissue culture of Stevia rebaudiana (Bertoni): A review. Journal of Pharmacognosy and Phytotherapy, 2013. 5(2), 26-33.
• Gupta, P., Sharma, S., & Saxena, S. Effect of salts (NaCl and Na 2 CO 3) on callus and suspension culture of Stevia rebaudiana for steviol glycoside production. Applied biochemistry and biotechnology, 2014. 172(6), 2894-2906.
• Ijaz, M., Pirzada, A. M., Saqib, M., & Latif, M. Stevia rebaudiana: An alternative sugar crop in Pakistan–a review. Erling Verl. GmbH Co. KG, 2015. 20(2), 88-96.
• Kampranis, S. C., & Makris, A. M. Developing a yeast cell factory for the production of terpenoids. Computational and structural biotechnology journal, 2012. 3(4), e201210006.
• Karimi, R., Vahedi, M., Pourmazaheri, H., & Balilashaki, K. Biotechnological approaches in Stevia rebaudiana and its therapeutic applications. Advances in Biomedicine and Pharmacy, 2017. 4(1): 31-43. Kim, M. J., Jin, J., Zheng, J., Wong, L., Chua, N. H., & Jang, I. C. Comparative transcriptomics unravel biochemical specialization of leaf tissues of Stevia (Stevia rebaudiana) for diterpenoid production. Plant physiology, 2015. pp-01353.
• King, R. M., & Robison, H. The Genera of the Eupatorieae (Asteraceae), Monographys in Systematic Botany, The Missouri Botanical Garden, 1987. KING, RM; ROBINSON, H., Eds.
• Kong, M. K., Kang, H. J., Kim, J. H., Oh, S. H., & Lee, P. C. Metabolic engineering of the Stevia rebaudiana ent-kaurene biosynthetic pathway in recombinant Escherichia coli. Journal of biotechnology, 2015. 214, 95-102.
• Lucho, S. R., do Amaral, M. N., Milech, C., Ferrer, M. Á., Calderón, A. A., Bianchi, V. J., & Braga, E. J. B. Elicitor-Induced Transcriptional Changes of Genes of the Steviol Glycoside Biosynthesis Pathway in Stevia rebaudiana Bertoni. Journal of Plant Growth Regulation, 2018. 1-15.
• Nature. https://www.nature.com/subjects/transcriptomics (accessed on 5 July 2018).
• Ohto, C., Muramatsu, M., Obata, S., Sakuradani, E., & Shimizu, S. Prenyl alcohol production by expression of exogenous isopentenyl diphosphate isomerase and farnesyl diphosphate synthase genes in Escherichia coli. Bioscience, biotechnology, and biochemistry, 2009. 73(1), 186-188.
• Modi, A., Litoriya, N., Prajapati, V., Rafalia, R., & Narayanan, S. Transcriptional profiling of genes involved in steviol glycoside biosynthesis in Stevia rebaudiana bertoni during plant hardening. Developmental Dynamics, 2014. 243(9), 1067-1073.
• Singh, S. D., & Rao, G. P. Stevia: The herbal sugar of 21 st Century. Sugar tech, 2005. 7(1), 17-24.
• Singh, G., Singh, G., Singh, P., Parmar, R., Paul, N., Vashist, R., & Kumar, S. Molecular dissection of transcriptional reprogramming of steviol glycosides synthesis in leaf tissue during developmental phase transitions in Stevia rebaudiana Bert. Scientific reports, 2017. 7(1), 11835.
• Sys, E. A., Marsolais, A. A., & Brandle, J. 1998. U.S. Patent Application No. 08/652,712.
• Tamokou, J. D. D., Mbaveng, A. T., & Kuete, V. Antimicrobial activities of African medicinal spices and vegetables. In Medicinal Spices and Vegetables from Africa 2017. (pp. 207-237).
• Valio, I. F. M., & Rocha, R. F. Effect of photoperiod and growth regulator on growth and flowering of Stevia rebaudiana Bertoni. Japanese Journal of Crop Science, 1977. 46(2), 243-248.
• Yadav, A. K., Singh, S., Dhyani, D., & Ahuja, P. S. A review on the improvement of stevia [Stevia rebaudiana (Bertoni)]. Canadian Journal of Plant Science, 2011. 91(1), 1-27.
• Yadav, S. K., & Guleria, P. Steviol glycosides from Stevia: biosynthesis pathway review and their application in foods and medicine. Critical reviews in food science and nutrition, 2012. 52(11), 988-998.
• Yoneda, Y., Nakashima, H., Miyasaka, J., Ohdoi, K., & Shimizu, H. Impact of blue, red, and far-red light treatments on gene expression and steviol glycoside accumulation in Stevia rebaudiana. Phytochemistry, 2017. 137, 57-65.
• Zaidan, L. B., Dietrich, S. M., & Felippe, G. M. Effect of photoperiod on flowering and stevioside content in plants of Stevia rebaudiana Bertoni. Japanese Journal of Crop Science, 1980. 49(4), 569-574.