Yıl 2021, Cilt 4 , Sayı 1, Sayfalar 46 - 60 2021-04-15

2,4-Dichlorophenoxyacetic Acid Loaded Polymeric Nanoparticle Synthesis and Its Effect on Biomass in Medicago sativa Cell Suspension Cultures

Fatma Şayan POYRAZ [1] , Edibe ABACI [2] , Caner ERTÜRK [3] , Tayfun ACAR [4] , Serap DERMAN [5] , Semiha ERİŞEN [6] , Banu MANSUROĞLU [7]

Nanoparticular systems, which have made great advances with the development of nanotechnology, have been used extensively recently in pesticide, herbicide plant growth regulators, fertilizer applications, gene transfer technologies and agriculture. It was aimed to synthesize and characterize 2,4-D loaded PLGA nanoparticles and investigate their biological activity in comparison with its free form. Here, the effects of 2,4-D loaded poly (lactic-co-glycolic) acid (PLGA) nanoparticles on biomass in Medicago sativa cell suspension cultures were investigated. Single emulsion solvent evaporation method is used in nanoparticle synthesis. As a result of the characterization of nanoparticles, 63.82% encapsulation efficiency, 60.73% reaction efficiency and 10.51% drug loading capacities were calculated. Particle size was measured as 181.7 ± 3.74 nm, zeta potential -18.3 ± 1.48 and polydispersity index as 0.081. Compared with the free 2,4-D molecule, it was observed that the addition of 2,4-D to the medium using the nanoparticles drug release system increased the growth of plant cells and the yield of biomass in M. sativa cell suspension cultures.
2,4-D, polymeric nanoparticle, Medicago sativa
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Birincil Dil en
Konular Biyoteknoloji
Bölüm Araştırma Makaleleri

Orcid: 0000-0002-6225-0721
Yazar: Fatma Şayan POYRAZ (Sorumlu Yazar)
Kurum: Yildiz Technical University
Ülke: Turkey

Orcid: 0000-0001-6075-0055
Yazar: Edibe ABACI
Kurum: Yildiz Technical University
Ülke: Turkey

Orcid: 0000-0001-9409-5589
Yazar: Caner ERTÜRK
Kurum: Yildiz Technical University
Ülke: Turkey

Orcid: 0000-0001-5006-8167
Yazar: Tayfun ACAR
Kurum: Yildiz Technical University
Ülke: Turkey

Orcid: 0000-0002-6662-6642
Yazar: Serap DERMAN
Kurum: Yildiz Technical University
Ülke: Turkey

Orcid: 0000-0002-0542-5118
Yazar: Semiha ERİŞEN
Kurum: Yildiz Technical University
Ülke: Turkey

Orcid: 0000-0001-8440-9118
Kurum: Yildiz Technical University
Ülke: Turkey


Yayımlanma Tarihi : 15 Nisan 2021

EndNote %0 International Journal of Life Sciences and Biotechnology 2,4-Dichlorophenoxyacetic Acid Loaded Polymeric Nanoparticle Synthesis and Its Effect on Biomass in Medicago sativa Cell Suspension Cultures %A Fatma Şayan Poyraz , Edibe Abacı , Caner Ertürk , Tayfun Acar , Serap Derman , Semiha Eri̇şen , Banu Mansuroğlu %T 2,4-Dichlorophenoxyacetic Acid Loaded Polymeric Nanoparticle Synthesis and Its Effect on Biomass in Medicago sativa Cell Suspension Cultures %D 2021 %J International Journal of Life Sciences and Biotechnology %P -2651-4621 %V 4 %N 1 %R doi: 10.38001/ijlsb.789851 %U 10.38001/ijlsb.789851