Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf.

Huseyin Askin Akpulat; Saliha Seyma Sahınler

Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf.

Abstract

In this study, chemical composition and in vitro antioxidant activity potential of the essential oil and various extracts of Inula graveolens (L.) Desf. were evaluated. While identifying the phytochemical composition of the essential oil and extract, GC-MS analyses were used. Chromatographic analysis of the essential oil resulted in identifying twenty compounds representing 99.5% of the total oil. Main constituents of the oil were determined as bornyl acetate (68.5%), borneol (7.7%), camphene (4.6%), epi-alpha-cadinol (4.0%) and eicosane (3.2%), respectively. Antioxidant activity was determined using four complementary test systems named beta-carotene/linoleic acid, DPPH free radical scavenging, reducing power, and chelating effect. A strong correlation between the antioxidant activity and phenolic acid contents of the samples was determined. The methanol extract was the most active one in all tested systems. The weakest activity was exhibited by chloroform extract. While methanol extract showed 88.34%, 91.38, and 63.43 activities in beta-carotene bleaching, DPPH radical scavenging, and chelating effect tests, respectively, the absorbance value in reducing power assay was measured as 0.273 nm.

Keywords

Kaynakça

Abu-Shanab, B., Adwan, G.M., Abu-Safiya, D., Jarrar, N., Adwan, K., 2005. Antibacterial activities of some plant extracts utilized in popular medicine in Palestine. Turkish Journal of Biology, 28, 99-102.
Afifi, F., Kasabri, V., Abaza, I., 2015. GC-MS composition and antiproliferative activity of Inula graveolens (L.) Desf. essential oil. Arabian Journal of Medicinal and Aromatic Plants, 1, 57-66.
Bagchi, D., Wetscher, G.J., Bagchi, M., Hinder, P.R., Perdikis, G., Stohs, S.J., Hinder, R.A., Das, D.K., 1997. Interrelationship between cellular calcium homeostasis and free radical generation in myocardial reperfusion injury. Chemico-Biological Interactions, 104, 65-85.
Blanc, M.C., Muselli, A., Bradesi, P., Casanova, J., 2004. Chemical composition and variability of the essential oil of Inula graveolens from Corsica. Flavour and Fragrance Journal, 19, 314-314.
Celiktas, O.Y., Kocabas, E.H., Bedir, E., Sukan, F.V., Ozek, T., Baser, K., 2007. Antimicrobial activities of methanol extracts and essential oils of Rosmarinus officinalis, depending on location and seasonal variations. Food Chemistry, 100, 553-559.
Dinis, T.C., Madeira, V.M., Almeida, L.M., 1994. Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Archives of Biochemistry and Biophysics, 315, 161-169.
Esterbauer, H., Schaur, R.J., Zollner, H., 1991. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radical Biology and Medicine, 11, 81-128.
Ghosn, M.W., Chemali, C.B., Zaknoun, F.I., Saliba, N.A., 2006. Chemical profle of the Dittrichia graveolens (Desf.) greuter essential oil of Lebanese origin. Journal of Essential Oil Research, 18, 443-444.

Gordon, M.H., 1990. The mechanism of antioxidant action in vitro. In: Hudson, B.J.F. (Ed.), Antioxidants. Elsevier Applied Science, London, New York, pp. 1–18.
Halliwell, B., Murcia, H.A., Chirco, S., Aruoma, O.I., 1995. Free radicals and antioxidants in food an in vivo: what they do and how they work. CRC Critical Reviews in Food Science and Nutrition, 35, 7–20.
Hatano, T., Kagawa, H., Yasuhara, T., Okuda, T., 1988. Two new flavonoids and other constituents in licorice root: their relative astringency and radical scavenging effects. Chemical and Pharmaceutical Bulletin, 36, 2090-2097.
Herraiz, T., Galisteo, J., Chamorro, C., 2003. L-tryptophan reacts with naturally occurring and foodoccurring phenolic aldehydes to give phenolic tetrahydro-β-caroline alkaloids: Activity as antioxidants and free radical scavengers. Journal of Agricultural and Food Chemistry, 51, 2168-2173.
Kelen, M., Tepe, B., 2008. Chemical composition, antioxidant and antimicrobial properties of the essential oils of three Salvia species from Turkish flora. Bioresource Technology, 99, 4096-4104.
Lanzetta, R., Lama, G., Mauriello, G., Parrilli, M., Racioppi, R., Sodano, G., 1991. Ichthyotoxic sesquiterpenes and xanthanolides from Dittrichia graveolens. Phytochemistry, 30, 1121-1124.
Lee, M.S., Choi, J., Posadzki, P., Ernst, E., 2012. Aromatherapy for health care: an overview of systematic reviews. Maturitas, 71, 257-260.
Pérez Gutierrez, R., Hernández Luna, H., Hernández Garrido, S., 2006. Antioxidant activity of Tagetes erecta essential oil. Journal of the Chilean Chemical Society, 51, 883-886.
Petropoulou, A., Tzakou, O., Verykokidou, E., 2004. Volatile constituents of Dittrichia graveolens (L.) Greuter from Greece. Journal of Essential Oil Research, 16, 400-401.
Rios, J.-L., Recio, M.C., 2005. Medicinal plants and antimicrobial activity. Journal of Ethnopharmacology, 100, 80-84.
Sevanian, A., Stein, R.A., Mead, J.F., 1981. Metabolism of epoxidized phosphatidylcholine by phospholipase A2 and epoxide hydrolase. Lipids, 16, 781-789.
Shimada, K., Fujikawa, K., Yahara, K., Nakamura, T., 1992. Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. Journal of Agricultural and Food Chemistry, 40, 945-948.
Tepe, B., Daferera, D., Tepe, A.-S., Polissiou, M., Sokmen, A., 2007. Antioxidant activity of the essential oil and various extracts of Nepeta flavida Hub.-Mor. from Turkey. Food Chemistry, 103, 1358-1364.
Weglicki, W.B., Dickens, B.F., Mak, I.T., 1984. Enhanced lysosomal phospholipid degradation and lysophospholipid production due to free radicals. Biochemical and Biophysical Research Communications, 124, 229-235.
Yamaguchi, T., Takamura, H., Matoba, T., Terao, J., 1998. HPLC method for evaluation of the free radical-scavenging activity of foods by using 1, 1-diphenyl-2-picrylhydrazyl. Bioscience, Biotechnology, and Biochemistry, 62, 1201-1204.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Eczacılık ve İlaç Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Huseyin Askin Akpulat ^* Bu kişi benim
0000-0001-8394-2746
Türkiye

Saliha Seyma Sahınler Bu kişi benim
0000-0003-4370-1686
Türkiye

Yayımlanma Tarihi

15 Aralık 2021

Gönderilme Tarihi

5 Temmuz 2021

Kabul Tarihi

1 Ağustos 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 1 Sayı: 1

IZ

https://izlik.org/JA86RM99ZF

Kaynak Göster

RIS / Bibtex

APA

Akpulat, H. A., & Sahınler, S. S. (2021). Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf. International Journal of Plant Based Pharmaceuticals, 1(1), 52-55. https://izlik.org/JA86RM99ZF

AMA

1.Akpulat HA, Sahınler SS. Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf. International Journal of Plant Based Pharmaceuticals. 2021;1(1):52-55. https://izlik.org/JA86RM99ZF

Chicago

Akpulat, Huseyin Askin, ve Saliha Seyma Sahınler. 2021. “Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf”. International Journal of Plant Based Pharmaceuticals 1 (1): 52-55. https://izlik.org/JA86RM99ZF.

EndNote

Akpulat HA, Sahınler SS (01 Aralık 2021) Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf. International Journal of Plant Based Pharmaceuticals 1 1 52–55.

IEEE

[1]H. A. Akpulat ve S. S. Sahınler, “Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf”., International Journal of Plant Based Pharmaceuticals, c. 1, sy 1, ss. 52–55, Ara. 2021, [çevrimiçi]. Erişim adresi: https://izlik.org/JA86RM99ZF

ISNAD

Akpulat, Huseyin Askin - Sahınler, Saliha Seyma. “Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf”. International Journal of Plant Based Pharmaceuticals 1/1 (01 Aralık 2021): 52-55. https://izlik.org/JA86RM99ZF.

JAMA

1.Akpulat HA, Sahınler SS. Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf. International Journal of Plant Based Pharmaceuticals. 2021;1:52–55.

MLA

Akpulat, Huseyin Askin, ve Saliha Seyma Sahınler. “Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf”. International Journal of Plant Based Pharmaceuticals, c. 1, sy 1, Aralık 2021, ss. 52-55, https://izlik.org/JA86RM99ZF.

Vancouver

1.Huseyin Askin Akpulat, Saliha Seyma Sahınler. Chemical composition and antioxidant activity of the essential oil and various extracts of Inula graveolens (L.) Desf. International Journal of Plant Based Pharmaceuticals [Internet]. 01 Aralık 2021;1(1):52-5. Erişim adresi: https://izlik.org/JA86RM99ZF