Araştırma Makalesi
BibTex RIS Kaynak Göster

Anti-diabetic Effects of Berberis cretica Extract in INS-1E Cells

Yıl 2021, Cilt: 3 Sayı: 2, 121 - 128, 24.08.2021
https://doi.org/10.38058/ijsl.983389

Öz

Berberine has been used for the adjuvant treatment of type 2 diabetes mellitus, hyperlipidemia (high levels of fats), and hypertension (high blood pressure). Also, it has different effects on diarrhea, inflammation, and cancer. Berberine, is a profoundly common compound in Berberis species. Although Berberis cretica is one of the Berberis species, it is unknown whether it has anti-diabetic effects yet. Also, synergistic effects of various compounds together with berberin or similar chemical forms of berberine within Berberis species can lead to find new anti-diabetic agents. The aim of this study is to investigate possible drug potential of Berberis cretica extract containing berberine and, its potential signaling pathways on Rat Insulinoma (INS-1E) cells. According to our results, Berberis cretica extract has anti-apoptotic effects in INS-1E cells decreasing expression p53, p38 and Bax genes. Suppressive effects of Berberis cretica plant extracts on apoptotic signalling pathways in β cells show that the extract contents can have a drug potential for treatment of diabetes.

Destekleyen Kurum

This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) 2209-A .

Proje Numarası

Project No: 1919B011603443

Kaynakça

  • Abrams, S. L., Follo, M. Y., Steelman, L. S., Lertpiriyapong, K., Cocco, L. et al. 2019. Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells, Advances in Biological Regulation, 71: 172-182.
  • Alemardan, A., Asadi, W., Rezaei, M., Tabrizi, L., Mohammadi, S. 2013. Cultivation of Iranian seedless barberry (Berberis integerrima ‘Bidaneh’): A medicinal shrub, Industrial Crops and Products, 50: 276-287.
  • Altinoz, E., Taskin, E., Oner, Z., Elbe, H., Atasever Arslan, B. 2015. The effect of saffron (Its active constituent, crocin) on The cardiovascular complication and dyslipidemia in streptozotocin induced diabetic rats, African Journal of Traditional, Complementary and Alternative Medicines, 12(5): 1-7.
  • Altundağ, E. M., Becer, E., Şanlıtürk, G., Güran, M., Vatansever, H. S. 2020. Berberin-Klorürün meme kanseri hücreleri üzerindeki sitotoksik etkilerinin değerlendirilmesi ve antimikrobiyal aktivite analizi, Turkiye Klinikleri Journal of Medical Sciences, 40(3): 342-348.
  • Chu, Q., Jiang, Y., Zhang, W., Xu, Du, W. et al., 2016. Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma, Oncotarget, 7: 84658-665.
  • Duran-Salgado, M. B., Rubio-Guerra, A. F. 2014. Diabetic nephropathy and inflammation, World J Diabetes, 5(3): 393-398.
  • Durmuş, R., Şahin, E., Bireller, S. 2016. Gestasyonel diyabette hipoglisemik etkili bitkilerin kullanımı, Deneysel Tıp Araştırma Enstitüsü Dergisi, 6(11): 3-16.
  • Ferranini, E. 1998. Insulin resistance versus insulin deficiency in noninsulin dependent diabetes mellitus: Problems and prospects, Endocrine Reviews, 19: 447-458.
  • İleritürk, M., Doğan, T., Kandemir, O. 2021. Investigation of the effect of berberine with arginase activity and oxidantantioxidant parameters on bortezomib-induced spleen injury in rats, Kocatepe Veterinary Journal, 14(1): 6-15.
  • Kigili, F., Ozen, F., Catal, T., Atasever Arslan, B. 2019. Androgen receptor (NR3C4) regulator potential of Ceratonia siliqua extract and its signaling pathways, Pharmacognosy Magazine, 15(62): 1-4
  • Kukula-Kocha, W., Aligiannis, N., Halabalaki, M., Skaltsounis, A. L., Glowniak, K., Kalpoutzakis, E. 2013. Influence of extraction procedures on phenolic content and antioxidant activity of cretan baberry herb, Food Chemistry, 138: 406-413.
  • Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W. et al. 2015. Meta-analysis of the effect and safety of berberine in the treatment of type 2 Diabetes mellitus, hyperlipemia and hypertension, Journal of Ethnopharmacol, 161: 69-81.
  • Li, H. L., Wu, H., Zhang, B. B., Shi, H.L., Wu, X.J. 2016. MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC 803 cell proliferation and IL-8 secretion in vitro and in vivo, Molecular Medicine Reports, 14(2): 1430-1438.
  • Li, J., He, W., Liao, B., Yang, J. 2015. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus, Scientific Reports, 31(5): 12724.
  • Oltvai, Z. N., Milliman, C. L., Korsmeyer, S. J. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death, Cell, 74: 609-619.
  • Onay-Beşikci, A., Güner, Ş. 2006. Diyabetik kalpte görülen mekanik ve metabolik değişimler ve bunlarin tedavisinde metabolik yaklaşım, Ankara Eczacılık Fakültesi Dergisi, 35(4): 297-317.
  • Puthdee, N., Seubwai, W., Vaeteewoottacharn, K., Boonmars, T., Cha'on, U. et al. 2017. Berberine induces cell cycle arrest in cholangiocarcinoma cell lines via inhibition of NF-kappaB and STAT3 pathways, Biological & Pharmaceutical Bulletin, 40(6): 751-757.
  • Rhodes, C. J. 2005. Type 2 diabetes-a matter of beta-cell life and death? Science, 307(5708): 380-384.
  • Salcini, C., Atasever-Arslan, B., Sunter, G., Gur H., Isik, F. B. et al. 2016. High plasma pentraxin 3 levels in diabetic polyneuropathy patients with nociceptive pain, The Tohoku Journal of Experimental Medicine, 239(1): 73-79.
  • Tabakoğlu, E., Durgut, R. 2013. Veteriner hekimlikte oksidatif stres ve bazı önemli hastalıklarda oksidatif stresin etkileri, Adana Veteriner Kontrol ve Araştırma Enstitüsü Dergisi, 3(1), 69-75.
Yıl 2021, Cilt: 3 Sayı: 2, 121 - 128, 24.08.2021
https://doi.org/10.38058/ijsl.983389

Öz

Proje Numarası

Project No: 1919B011603443

Kaynakça

  • Abrams, S. L., Follo, M. Y., Steelman, L. S., Lertpiriyapong, K., Cocco, L. et al. 2019. Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells, Advances in Biological Regulation, 71: 172-182.
  • Alemardan, A., Asadi, W., Rezaei, M., Tabrizi, L., Mohammadi, S. 2013. Cultivation of Iranian seedless barberry (Berberis integerrima ‘Bidaneh’): A medicinal shrub, Industrial Crops and Products, 50: 276-287.
  • Altinoz, E., Taskin, E., Oner, Z., Elbe, H., Atasever Arslan, B. 2015. The effect of saffron (Its active constituent, crocin) on The cardiovascular complication and dyslipidemia in streptozotocin induced diabetic rats, African Journal of Traditional, Complementary and Alternative Medicines, 12(5): 1-7.
  • Altundağ, E. M., Becer, E., Şanlıtürk, G., Güran, M., Vatansever, H. S. 2020. Berberin-Klorürün meme kanseri hücreleri üzerindeki sitotoksik etkilerinin değerlendirilmesi ve antimikrobiyal aktivite analizi, Turkiye Klinikleri Journal of Medical Sciences, 40(3): 342-348.
  • Chu, Q., Jiang, Y., Zhang, W., Xu, Du, W. et al., 2016. Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma, Oncotarget, 7: 84658-665.
  • Duran-Salgado, M. B., Rubio-Guerra, A. F. 2014. Diabetic nephropathy and inflammation, World J Diabetes, 5(3): 393-398.
  • Durmuş, R., Şahin, E., Bireller, S. 2016. Gestasyonel diyabette hipoglisemik etkili bitkilerin kullanımı, Deneysel Tıp Araştırma Enstitüsü Dergisi, 6(11): 3-16.
  • Ferranini, E. 1998. Insulin resistance versus insulin deficiency in noninsulin dependent diabetes mellitus: Problems and prospects, Endocrine Reviews, 19: 447-458.
  • İleritürk, M., Doğan, T., Kandemir, O. 2021. Investigation of the effect of berberine with arginase activity and oxidantantioxidant parameters on bortezomib-induced spleen injury in rats, Kocatepe Veterinary Journal, 14(1): 6-15.
  • Kigili, F., Ozen, F., Catal, T., Atasever Arslan, B. 2019. Androgen receptor (NR3C4) regulator potential of Ceratonia siliqua extract and its signaling pathways, Pharmacognosy Magazine, 15(62): 1-4
  • Kukula-Kocha, W., Aligiannis, N., Halabalaki, M., Skaltsounis, A. L., Glowniak, K., Kalpoutzakis, E. 2013. Influence of extraction procedures on phenolic content and antioxidant activity of cretan baberry herb, Food Chemistry, 138: 406-413.
  • Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W. et al. 2015. Meta-analysis of the effect and safety of berberine in the treatment of type 2 Diabetes mellitus, hyperlipemia and hypertension, Journal of Ethnopharmacol, 161: 69-81.
  • Li, H. L., Wu, H., Zhang, B. B., Shi, H.L., Wu, X.J. 2016. MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC 803 cell proliferation and IL-8 secretion in vitro and in vivo, Molecular Medicine Reports, 14(2): 1430-1438.
  • Li, J., He, W., Liao, B., Yang, J. 2015. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus, Scientific Reports, 31(5): 12724.
  • Oltvai, Z. N., Milliman, C. L., Korsmeyer, S. J. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death, Cell, 74: 609-619.
  • Onay-Beşikci, A., Güner, Ş. 2006. Diyabetik kalpte görülen mekanik ve metabolik değişimler ve bunlarin tedavisinde metabolik yaklaşım, Ankara Eczacılık Fakültesi Dergisi, 35(4): 297-317.
  • Puthdee, N., Seubwai, W., Vaeteewoottacharn, K., Boonmars, T., Cha'on, U. et al. 2017. Berberine induces cell cycle arrest in cholangiocarcinoma cell lines via inhibition of NF-kappaB and STAT3 pathways, Biological & Pharmaceutical Bulletin, 40(6): 751-757.
  • Rhodes, C. J. 2005. Type 2 diabetes-a matter of beta-cell life and death? Science, 307(5708): 380-384.
  • Salcini, C., Atasever-Arslan, B., Sunter, G., Gur H., Isik, F. B. et al. 2016. High plasma pentraxin 3 levels in diabetic polyneuropathy patients with nociceptive pain, The Tohoku Journal of Experimental Medicine, 239(1): 73-79.
  • Tabakoğlu, E., Durgut, R. 2013. Veteriner hekimlikte oksidatif stres ve bazı önemli hastalıklarda oksidatif stresin etkileri, Adana Veteriner Kontrol ve Araştırma Enstitüsü Dergisi, 3(1), 69-75.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Research Articles
Yazarlar

Yiğit Deveci 0000-0002-4148-9688

Gamze Günal Sadık 0000-0003-0610-0726

Emine Akalın 0000-0002-0307-2128

Seda Kuşoğlu Gültekin 0000-0003-0674-1582

Ayşegül Yanık 0000-0002-6989-9355

Belkis Atasever Arslan 0000-0001-5827-8484

Proje Numarası Project No: 1919B011603443
Yayımlanma Tarihi 24 Ağustos 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 3 Sayı: 2

Kaynak Göster

APA Deveci, Y., Günal Sadık, G., Akalın, E., Kuşoğlu Gültekin, S., vd. (2021). Anti-diabetic Effects of Berberis cretica Extract in INS-1E Cells. International Journal of Science Letters, 3(2), 121-128. https://doi.org/10.38058/ijsl.983389
AMA Deveci Y, Günal Sadık G, Akalın E, Kuşoğlu Gültekin S, Yanık A, Atasever Arslan B. Anti-diabetic Effects of Berberis cretica Extract in INS-1E Cells. IJSL. Ağustos 2021;3(2):121-128. doi:10.38058/ijsl.983389
Chicago Deveci, Yiğit, Gamze Günal Sadık, Emine Akalın, Seda Kuşoğlu Gültekin, Ayşegül Yanık, ve Belkis Atasever Arslan. “Anti-Diabetic Effects of Berberis Cretica Extract in INS-1E Cells”. International Journal of Science Letters 3, sy. 2 (Ağustos 2021): 121-28. https://doi.org/10.38058/ijsl.983389.
EndNote Deveci Y, Günal Sadık G, Akalın E, Kuşoğlu Gültekin S, Yanık A, Atasever Arslan B (01 Ağustos 2021) Anti-diabetic Effects of Berberis cretica Extract in INS-1E Cells. International Journal of Science Letters 3 2 121–128.
IEEE Y. Deveci, G. Günal Sadık, E. Akalın, S. Kuşoğlu Gültekin, A. Yanık, ve B. Atasever Arslan, “Anti-diabetic Effects of Berberis cretica Extract in INS-1E Cells”, IJSL, c. 3, sy. 2, ss. 121–128, 2021, doi: 10.38058/ijsl.983389.
ISNAD Deveci, Yiğit vd. “Anti-Diabetic Effects of Berberis Cretica Extract in INS-1E Cells”. International Journal of Science Letters 3/2 (Ağustos 2021), 121-128. https://doi.org/10.38058/ijsl.983389.
JAMA Deveci Y, Günal Sadık G, Akalın E, Kuşoğlu Gültekin S, Yanık A, Atasever Arslan B. Anti-diabetic Effects of Berberis cretica Extract in INS-1E Cells. IJSL. 2021;3:121–128.
MLA Deveci, Yiğit vd. “Anti-Diabetic Effects of Berberis Cretica Extract in INS-1E Cells”. International Journal of Science Letters, c. 3, sy. 2, 2021, ss. 121-8, doi:10.38058/ijsl.983389.
Vancouver Deveci Y, Günal Sadık G, Akalın E, Kuşoğlu Gültekin S, Yanık A, Atasever Arslan B. Anti-diabetic Effects of Berberis cretica Extract in INS-1E Cells. IJSL. 2021;3(2):121-8.