Evaluation of HPV 16 positive cases

Öz

Objective: The most significant risk factor for cervical cancer is a positive HPV test. Among the types of HPV, types 16 and 18 pose the highest risk. In cases where HPV is found to be positive, particularly in high-risk HPV types, colposcopy and cervical biopsy examination are recommended. Our study will evaluate the smear results of patients who are positive for HPV type 16. Material and Methods: We evaluated the correlation between age and cervical biopsy results in 1062 patients who tested positive for HPV type 16. The age, smear, and colposcopic biopsy results of the cases were recorded. Every woman participating in the screening gave two samples, one for the traditional cytology test and the other for the HPV DNA test. Tissue sampling was performed within a month, including colposcopic biopsy, Loop Electrosurgical Excision Procedure (LEEP), conization, and hysterectomy of 1062 patients. Diagnoses obtained from histological samples were taken as the gold standard. Results: The study included 1062 female patients who tested positive for isolated HPV type 16. The average age of the patients was determined to be 42.02±8.81 (min:21, max:77). When smoking usage was examined, it was found that 482 (45.4%) were smokers, while 580 (54.6%) were non-smokers. 284 (26.7%) of the patients were menopausal. The relationship between age, menopausal status, and smoking usage with smear and colposcopy results in women positive for HPV type 16 was examined. No statistically significant result was found. Conclusion: There is no correlation between age, menopausal status, and smoking usage with smear and colposcopy results in women positive for HPV type 16. The most significant risk factor for abnormal smear and colposcopy results, in line with the literature, is HPV type 16 itself.

Anahtar Kelimeler

• Hpv 16
• smear
• colposcopy
• biopsy

HPV 16 pozitif vakaların değerlendirilmesi

Öz

Amaç: Serviks kanseri için gösterilmiş en önemli risk faktörü HPV pozitifliğidir. HPV tipleri arasında ise en yüksek riske sahip olan tipler ise 16 ve 18’dir. HPV incelemesi sonucunda yüksek riskli HPV tiplerinde kolposkopi ve serviks biyopsisi incelemesi önerilmektedir. Biz bu çalışmada HPV tip 16 pozitif hastaların smear sonuçları değerlendirilmiştir. Gereç ve yöntem: 1062 adet HPV tip 16 pozitif hastanın yaş ile korelasyonunu ve servikal biyopsi sonuçlarını değerlendirdik. Olguların yaş, smear ve kolposkopik biyopsi sonuçları kaydedildi. Taramaya katılan her kadın, biri geleneksel sitoloji testi ve diğeri HPV DNA testi olmak üzere iki örnek alındı. Test sonuçları, hastanemiz Patoloji laboratuvarında 2001 Bethesda sınıflandırması esas alınarak yorumlanmasıyla elde edilmiştir. 1062 hastanın kolposkopik biyopsi, Loop Electrosurgical Excision Procedure (LEEP), konizasyon ve histerektomi dahil olmak üzere bir ay içinde takip doku örneklemesi yapıldı. Histolojik örneklerden elde edilen tanılar altın standart olarak alındı. Bulgular: Çalışmaya izole HPV tip 16 pozitif 1062 kadın hasta dahil edildi. Hastaların ortalama yaşı 42,02±8,81 (min:21, max:77) olarak tespit edildi. Sigara kullanımı incelendiğinde 482 (%45,4)’si sigara kullanmakta olduğu görüldü. Hastaların 284 (%26,7)’ü menopozda idi. HPV tip 16 pozitif kadınlarda smear ve kolposkopi sonuçlarının yaş, menopozla durum, sigara kullanımı ile ilişkisi incelendi. İstatistiksel olarak anlamlı sonuç saptanmadı. Sonuç: HPV tip 16 pozitif kadınlarda smear ve kolposkopi sonuçlarının yaş, menopozla durum ve sigara kullanımı ile ilişkisi yoktur. Anormal smear ve kolposkopi sonucu için en önemli risk faktörü, literatür ile uyumlu olarak, HPV tip 16’nın kendisidir.

Anahtar Kelimeler

• Hpv 16
• smear
• kolposkopi
• biyopsi

Kaynakça

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