The first political structures of Ukraine and Russia are the Kyiv Principality. The Russians, who retreated to the north as a result of the Mongol attacks, established the Moscow Principality. This principality later attacked Kyiv. There are claims that Ukrainian identity was suppressed and Ukrainians were exploited during the reigns of Peter I and Catherine II. Millions of Ukrainians died as a result of the Holodomor events of 1932-1933. There are accusations that Ukrainian nationalists collaborated with the Germans in World War II. The status of the Black Sea fleet transferred to Ukraine was much discussed later. After independence, Ukraine preferred to turn to the West. Historical facts and claims like these constitute historical breaking points between Russian and Ukrainian society. After the collapse of the Soviet Union in 1991, the Orange revolution, the Euromaidan events, the occupation of Crimea by Russia in 2014, and the direct support of the separatist groups in the Donetsk and Lugansk regions by Russia, the process of separating Russia and Ukraine from each other became irreversible. With Ukraine's efforts to become a member of NATO, the crisis in the relations between the two countries turned into a war with Russia's attack on Ukraine on February 24, 2022. Central Asian countries are at the forefront of the regions affected by the Russia-Ukraine war. In the process after the start of the war, Central Asian countries are feeling the effects of the war, especially economically, politically and socially. This study attempts to assess in detail Russian-Ukrainian relations from a historical perspective, the turning points in these relations and beginning Russian-Ukrainian war, sanctions against Russia, as well as the impact of the Russian-Ukrainian war on the countries of Central Asia and China's relations with Central Asia in this process.